Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1. Anesthetized dogs were given phencyclidine HCl (
PCP
) by intracerebroventricular (i.c.v.) injection. 2. Physiological parameters were monitored after consecutive doses of 0.5, 1.0 and 2.0 mg of
PCP
. 3. Dose-related changes seen, including bradycardia, hypotension and
bradypnea
, were opposite to those produced by i.v. doses. 4. Single doses of 1.0 or 2.0 mg of
PCP
confirmed the prior observations, and the latter provided the baseline for further observations on dogs receiving
PCP
before various i.c.v. pretreatments--atropine, haloperidol, phentolamine or propranolol--in efforts to characterize the central neurotransmitter system(s) involved in the
PCP
effects.
...
PMID:Respiratory and circulatory effects of centrally administered phencyclidine in anesthetized dogs. 176 Dec
