Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Studies on the effects of
PCP
have been conducted in volunteers in the Army Laboratories and elsewhere and in illicit users. The present review has summarized the observations of many investigators which showed that the acute effects of
PCP
following several routes of administration were shown to be dose-related. High doses of
PCP
produce disturbing manifestations including psychosis, numbness, light-headedness,
vertigo
, ataxia, and nystagmus due to acute intoxication. Furthermore, some subjects became irritable, argumentative or negative under the conditions of social stress and demanding tasks. In addition to a variety of central action,
PCP
has also been shown to affect cardiovascular function, heat storage, and exercise performance.
PCP
can also induce, although rarely, prolonged toxic psychosis in chronic abusers and precipitate psychotic episodes in psychotic and prepsychotic personalities. Tolerance, but not physical dependence, develops to the effects of
PCP
. Psychologic dependence as indicated by craving for the drug has however been reported.
...
PMID:Phencyclidine (PCP): some human studies. 651 53
