Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Morphine elicited a dose-related increase in the duration of phencyclidine (
PCP
)-induced motor incoordination. In the open field behavioral observations, morphine enhanced the
PCP
-induced decrease in the number of ambulation and rearing. Morphine potentiated the
PCP
-induced decrease in body temperature. The LD50 of
PCP
was significantly decreased in the presence of morphine. An opiate antagonist, naloxone, antagonized the morphine-induced effects without influencing the pharmacological actions of
PCP
itself. The levels of hepatic microsomal cytochrome P-450 and
cytochrome b5
and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment. The half-lives of
PCP
in serum and brain were increased by the concurrent administration of morphine. The ratio of the liver weight to body weight and aniline hydroxylase activity in hepatic microsomal fraction were decreased in the morphine-treated group compared with the control group; this is indicative of a possible reduction in the oxidative metabolism of
PCP
. The results indicate that acute administration of morphine enhances a variety of pharmacological effects of
PCP
; an inhibition of
PCP
disposition by morphine may be a mechanism involved in this process.
...
PMID:Effect of morphine on the responses to and disposition of phencyclidine in mice. I. Enhancement of phencyclidine effects by acute morphine administration. 684 96
Development of tolerance to phencyclidine (
PCP
) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a
PCP
(1-3 mg/day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the
PCP
pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450,
cytochrome b5
and nicotinamide adenine dinucleotide phosphatase (NADPH)-cytochrome c reductase activities were found to be elevated in tolerant mice (2 mg/day/mouse for 5 days). The half-life of
PCP
in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for
PCP
. It appears that the administration of
PCP
by the osmotic minipump offers a convenient method for inducing
PCP
tolerance.
...
PMID:Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse. 710 47
