Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of acute and chronic administration of phencyclidine (PCP) on both neocortical and subcortical visual potentials (VEPs) and on spontaneous EEGs were studied in the rhesus monkeys with permanently implanted brain electrodes. VEPs were evoked by brief single photo-stimulator flashes (0.8 pps. 10 microsec duration). Injection of PCP (0.5 to 4.0 mg/kg doses, IV) in monkeys produced a significant inhibition on the peak-amplitude of major VEP components predominantly in the occipital lobe and hippocampus. The PCP-induced VEP inhibition persisted in the presence of occipital and hippocampal theta-activities. Nystagmus persisted throughout the 6 to 8 hours course of PCP-induced behavior. A biphasic pattern of inhibitory and excitatory effects on EEGs and behavior was also observed during the 6 to 8 hours observation period. Chronic administration of PCP (2.0 and 4.0 mg/kg dose IV daily) produced a significant decrease in its inhibitory effects on VEPs, suggesting tolerance development to the inhibitory effect on VEPs. The results suggest that the hippocampus has important implications in the modulation of PCP effects on CNS activities related to the visual function of the rhesus monkey.
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PMID:Effects of phencyclidine (PCP) on the visual evoked potentials in the rhesus monkey. 682 65

In 1,000 cases of phencyclidine (PCP) intoxication evaluated at the time of first examination in an emergency department, the incidence of "typical" findings was found to be lower than has been reported previously. Nystagmus and hypertension occurred in only 57% of our cases; some patients had only one of these findings and many had neither. The incidence of violence was 35%; bizarre behavior, 29%; and agitation, 34%. Changes in sensorium consisted of coma, lethargy/stupor, and acute brain syndrome; however, 46% of patients were alert and oriented. Motor signs included grand mal seizures, generalized rigidity, localized dystonias, catalepsy, and athetosis. Profuse diaphoresis, hypersalivation, bronchospasm, and urinary retention occurred in less than 5%. A small percentage had severe disturbances in vital signs, including three cases (0.3%) of cardiac arrest and 28 cases (2.8%) of apnea. Hypoglycemia and elevated serum CPK, uric acid, and SGOT/SPGT were common. Urine PCP levels did not correlate with the severity of the clinical findings.
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PMID:Acute phencyclidine intoxication: incidence of clinical findings in 1,000 cases. 722 71