Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper describes interactions between primary care physicians (PCP's) and mental health clinicians (MHC's) in a "team collaborative model." A study of the interactions showed there were about two consultations a day with PCP's for each MHC, that they were largely unscheduled, took place mostly in PCP or MHC offices or in corridors, and increased in frequency over a two-year period. Role definition was a continuing process; PCP's and MHC's each learned through repeated discussions what to expect from the other in patient care. It is found that a model with close working arrangements between PCP's and MHC's is of therapeutic value for that large population of emotionally disturbed patients seen often by PCP's much less often by MHC's.
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PMID:Collaboration, consultation and referral in an integrated health-mental health program at an HMO. 51 94

Delinquent males committed to a training school were interviewed to determine the extent and the effects of phencyclidine use. Nine of 109 (8%) drug using subjects knowingly had used phencyclidine in the past. These nine subjects were multiple drug abusers of other substances and had started taking drugs at an average age of 9.38 years which was significantly younger than non PCP users. Six of the nine PCP users had committed proven offenses against persons and in four cases violent actions were directly attributed to PCP use. Suicide attempts were made by five (55%) of the PCP users which was significantly more frequent than suicide attempts made by non PCP users.
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PMID:Phencyclidine use in delinquent males committed to a training school. 52 14

A solution of internal standard in acetonitrile is used to extract samples of wood from lumber which had been commercially treated with chlorinated phenols. The tetrachlorophenol(TCP) and pentachlorophenol( PCP) were analytically separated from each other and from the other wood extractive compounds using a high performance liquid chromatograph (HPLC). The ultraviolet (UV) absorptions of the TCP, PCP, and internal standard were automatically measured as they eluted. The UV absorption peaks were integrated, and the amounts of TCP and PCP present were calculated with a dedicated microcomputer. Compared with the method previously used, this method is faster (up to 144 samples per 48 hours), has the same accuracy and precision, and it is linear over the concentration range used.
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PMID:Determination of chlorinated phenols in surface-treated lumber by HPLC. 52 76

The effects of acute IP administration of phencyclidine (PCP), d-amphetamine (AMPH) and pentobarbital (PB) were determined in 10 mice trained to lever press on a differential reinforcement of low rate 10 sec schedule of sweetened milk presentation. The effects of PCP were highly consistent, with large response rate increases (and a corresponding shift toward shorter interresponse times) at doses of 1 and 3 mg/kg. Higher doses generally decreased response rates and resulted in a bimodal interresponse time distribution. The effects of AMPH were similar to PCP but less consistent. Although some of the subjects showed substantial response rate increases at doses between 0.3 and 10 mg/kg, half of the subjects did not show increased response rates at any dose. The effects of AMPH on the interresponse time distribution were similar to PCP. The effects of PB were least like those of PCP. The effect in most subjects was to produce a dose-related decrease in response rate and a flattening of the interresponse time distribution. Occasional small response rate increases were observed with PB.
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PMID:Effects of phencyclidine, d-amphetamine and pentobarbital on spaced responding in mice. 53 50

The performance of sober (average length of abstinence = 27 months) phencyclidine (PCP) abusers on neuropsychological measures of organicity was compared to that of polydrug users who were not experienced with PCP, and to controls who were not alcohol or drug abusers. Six of 12 PCP users, five of 12 polydrug users, and none of the controls showed neuropsychological impairments. The deficits in PCP users occurred despite negative medical-neurological history, and even though the PCP group abused other drugs previously associated with neuropsychological impairment less than the polydrug group. Deficiencies in abstracting and in perceptual-motor integrative abilities were noted. The results suggest the possibility that PCP abuse might be associated with neuropsychological disturbance which persists for considerable time after PCP use ceases.
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PMID:Is phencyclidine (PCP) abuse associated with organic mental impairment?. 53 70

The abuse of phencyclidine [1(1-phencylohexyl)piperidine, PCP], commonly referred to as angel dust or hog, is rapidly reaching epidemic proportions. PCP users often appear violent and increases in PCP-implicated homicides and suicides have been reported. In animal studies PCP has been demonstrated in brain up to 48 h after administration, long after blood levels become undetectable. However, there is little further information on the distribution of PCP within the central nervous system with regard to the possible sites of action. Recently, Sokoloff and associates described a new technique which can be used to visualise possible sites of drug action. The technique is based on the premise that neuronal activity is closely related to energy metabolism. Therefore, by directly monitoring 2-deoxy-D-glucose consumption before and after a pharmacological stimulus, we can obtain autoradiographic evidence of changes in neuronal activity in discrete areas brain as a response to that stimulus. Using this procedure, we now report that PCP causes dramatic changes in glucose metabolism in very specific regions of the rat brain.
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PMID:Localisation of phencyclidine-induced changes in brain energy metabolism. 55 Dec 94

A reactive ATP analog, N6-(6-bromoacetamidohexyl)-AMP.PCP, was synthesized in an attempt to covalently label the binding sites for adenine nucleotides, especially ATP, of various enzymes which utilize adenine nucleotides as substrates, cofactors, inhibitors or allosteric effectors. This reagent rapidly inactivated rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPD), myokinase (MK), and creatine kinase (CK) under very mild conditions. Adenine nucleotide substrates prevented the inactivation. In the case of GPD, complete inactivation was observed when 1 mol of the reagent per mol of enzyme subunit was incorporated into the enzyme. These results indicate that the present ATP analog may be useful as an affinity labeling reagent for various adenine nucleotide-dependent enzymes.
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PMID:Synthesis of a reactive ATP analog and its preliminary application as an affinity labeling reagent. 56 99

Behavioral rating scales were developed for quantification of phencyclidine (PCP)-induced locomotor activity, stereotyped behavior and ataxia in rats. The dose-response relationship for PCP-induced locomotor activity was found to be an inverted U-shaped function over the first 25 min after injection while over the last 30 min of the experiment the function was highly linear. A linear dose-response relationship was found for ratings of stereotyped behavior and ataxia throughout the 90 min period of observation. The ratings of these two behaviors were found to be closely parallel. The effects of PCP on locomotor activity were found to be greatest during those intervals when stereotyped behavior and ataxia were at moderate levels. Ratings of locomotor activity may be confounded by ataxia when PCP is administered alone or in combination with other drugs.
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PMID:Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. 57 93

Trained interviewers utilized a structured research instrument to analyze drug use patterns, personal and familial psychiatric problems, and social backgrounds of a consecutive series of 355 adolescent referred by courts to alcohol counselling and education centers in King County. Within this sample, 4% of the subjects used propoxyphene alone, 16% reported use of phencyclidine (PCP) alone, and 6% reported abuse of both substances. The data consistently reveals that the use of one of these more unusual substances is likely to occur in people with more antisocial, drug, and alcohol problems. Use of both drugs was associated with the most pervasive antisocial history, with over one-third of these subjects fulfilling strict criteria for the antisocial personality. The treatment and prognostic implications of these findings are discussed.
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PMID:Propoxyphene and Phencyclidine (PCP) use in adolescents. 58 Feb 63

The nosological independence of psoriatic arthritis is discussed in the light of the literature. The clinical and laboratory pictures of infantile psoriasis and PCP are described. Three cases of infantile psoriatic polyarthritis are presented and attention is drawn to the difficulty of diagnosing this condition in children. Longitudinal assessment of the possibility of early onset on the part of forms becoming evident during adulthood is envisaged.
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PMID:[Psoriatic polyarthritis in childhood. Clinico-nosological study]. 61 Jun 91


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