Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Specific [3H]phencyclidine (
PCP
)-binding studies were carried out in homogenates prepared from different regions of post-mortem human brains derived from subjects free of any
neurological disease
. Scatchard analysis revealed a single class of [3H]
PCP
-binding sites. Binding was found to be stereospecific i.e. markedly greater ability of the potent
PCP
agonist dexoxadrol to displace specifically bound 10 nM [3H]
PCP
as compared to its behaviorally inactive enantiomer levoxadrol. Stereospecific binding was abolished by preincubation of homogenate with trypsin or by heating the homogenate to 90 degrees C for 15 min. Various sigma opiates displaced specifically bound [3H]
PCP
binding in a rank order similar to that seen in rat brain. Thus a baseline has been established to enable future elucidation of the possible role of these sites in psychiatric illnesses.
...
PMID:Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain. 631 73
