Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen cases of rhabdomyolysis-associated acute renal failure among phencyclidine (PCP) users were seen at our institution between 1979-1984. An additional 15 cases were found from the literature. These 30 cases are reviewed here with respect to the incidence of acute renal failure among PCP users, its possible pathogenesis, clinical and biochemical features, and treatment.
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PMID:A review of thirty cases of rhabdomyolysis-associated acute renal failure among phencyclidine users. 383 78

Medical records of 107 consecutive patients with a diagnosis of phencyclidine (PCP) intoxication were reviewed and in 27 of these the diagnosis was confirmed by positive urine assay. In the 27 confirmed cases, the most common abnormalities present on physical examination were mental/behavioral (89%) and nystagmus (85%). Elevations in blood pressure, temperature, and heart rate that were statistically significant when compared with an age-matched control group also were noted. Review of available medical records disclosed that 13 of these patients had been evaluated previously at our institution for PCP intoxication. Toxicological screening tests including blood alcohol level, hypnotic screen, and urine test for alkaloids, were performed on 11 patients and found positive in four. The most common serious medical complication requiring hospitalization was rhabdomyolysis which occurred on three patients, two of whom developed acute renal failure. This complication may occur more frequently than previously recognized and should be excluded in patients with PCP intoxication.
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PMID:Phencyclidine intoxication: clinical experience in 27 cases confirmed by urine assay. 722 72

Rhabdomyolysis occurred in 25 of 1,000 patients (2.5%) with phencyclidine (PCP) intoxication. 10 of these 25 patients (40%) developed acute renal failure and another 7 had mild impairment in renal function. Marked hyperuricemia was present in all 17 patients, and marked hyperphosphatemia and hypocalcemia were noted in the 10 patients with acute renal failure; 3 of the latter developed hypercalcemia during the diuretic phase of the illness. Fever, tachycardia and hypertension were frequent findings among the 25 patients with rhabdomyolysis and all had leukocytosis. The data show that rhabdomyolysis with and without acute renal failure is not infrequent among abusers of PCP.
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PMID:Rhabdomyolysis with and without acute renal failure in patients with phencyclidine intoxication. 734 47

Rhabdomyolysis can occur with phencyclidine hydrochloride (PCP) intoxication. However, to our knowledge acute renal failure with phencyclidine-induced rhabdomyolysis has not been reported previously. Therefore, we describe two patients with this condition. The modern treatment of phencyclidine intoxication, namely aggressive acidification and diuretic therapy, can enhance the risk of acute renal failure in patients with rhabdomyolysis. Therefore, exclusion of rhabdomyolysis is essential before acidification measures are undertaken.
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PMID:Rhabdomyolysis and acute renal failure associated with phencyclidine intoxication. 736 95