Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Trained interviewers utilized a structured research instrument to analyze drug use patterns, personal and familial psychiatric problems, and social backgrounds of a consecutive series of 355 adolescent referred by courts to alcohol counselling and education centers in King County. Within this sample, 4% of the subjects used propoxyphene alone, 16% reported use of phencyclidine (PCP) alone, and 6% reported abuse of both substances. The data consistently reveals that the use of one of these more unusual substances is likely to occur in people with more antisocial, drug, and alcohol problems. Use of both drugs was associated with the most pervasive antisocial history, with over one-third of these subjects fulfilling strict criteria for the antisocial personality. The treatment and prognostic implications of these findings are discussed.
 ...
PMID:Propoxyphene and Phencyclidine (PCP) use in adolescents. 58 Feb 63

In 155 polydrug abusers, drug use patterns that were associated with serious suicidal behavior included preference for depressant drugs, history of withdrawal from barbiturates, and lower frequency of PCP use. Diagnostic factors associated with increased suicidal behavior included a history of depression in the subject's mother and a diagnosis of antisocial personality in the subjects themselves. These findings are discussed in relation to Winokur's concept of broad spectrum depressive disease.
 ...
PMID:Factors associated with suicidal behavior in polydrug abusers. 744 May 11

Predictors of non-response were investigated in a 15-year follow-up (1981-1996) of 3,481 individuals in a probability sample from the household population of East Baltimore. Demographics (age, sex, race, education, marital status, and unemployment), household factors (living arrangements, household income, household size, and number of children), cultural variables (ancestral ethnicity and foreign language), social variables (social support and networks, committing felony, carrying a weapon, using an alias, and wandering), health factors (physical illness, health insurance, medical assistance, Medicare, receiving disability benefits, social security, and welfare), interviewer's observation, and psychopathologic variables (mental disorders, suicide behavior, comorbidity, and drug use) were collected at baseline in 1981 and in 1982, then linked to follow-up data between 1993 and 1996. A tracing process involving mail, phone, criss-cross directories, motor vehicle administration records, a commercial credit bureau, the state criminal justice system, hospital records, the US National Death Index, and field tracing were used to locate the original sample. A total of 3,066 respondents of the original sample (88.1%) were traced. Non-response was categorized into Sample Mortality (that part of the original sample that died during follow-up), Sample Loss (that part of the original sample that survived but could not be found) and Refusal (that part of the original sample that survived and was found but refused to participate). Stratified analysis and adjusted multiple logistic regression modeling found sample mortality and sample loss were strongly influenced by individual and household variables and by psychopathology. Sample mortality was influenced by specific mental disorders or conditions as mania, drug abuse/dependency, antisocial personality, cognitive impairment, alcohol abuse/dependency, phobia, drug use (except PCP), and comorbidity. Household factors protective against mortality include higher household income, not living as extended members in a married couple family, and living with children in the household. Persons who were unemployed, widowed or single, without high school education, male, and 65 years of age or older were more likely to die. Sample loss was influenced by cognitive impairment, antisocial personality, and cocaine use. Household factors linked to sample loss include living in female-headed families, or non-family households, and living alone. Young nonwhite, divorced/separated, without high school education, and unemployed were also harder to find. Refusal was associated with being white, with incomplete elementary education, living as a spouse in traditional married couple families, or as a child in female-headed families. Psychopathology did not influence refusal.
 ...
PMID:Psychopathology and attrition in the Baltimore ECA 15-year follow-up 1981-1996. 1018 15

Discrepancies between biological assays and self-report of illicit drug use could undermine epidemiological research findings. Two objectives of the present study are to examine the degree of agreement between self-reported illicit drug use and hair analysis in a community sample of middle-aged men, and to identify factors that may predict discrepancies between self-report and hair testing. Male participants followed since 1972 were interviewed about substance use, and hair samples were analyzed for marijuana, cocaine, opiates, phencyclidine (PCP) and methamphetamine using radioimmunoassay and gas chromatography-mass spectrometry (GC-MS) techniques. Self-report and hair testing generally met good, but not excellent, agreement. Apparent underreporting of recent cocaine use was associated with inpatient hospitalization for the participant's most recent quit attempt, younger age, identifying as African American or other, and not having a diagnosis of antisocial personality disorder. The overestimate of marijuana use relative to hair test was associated with frequent use since 1972 and providing an inadequate hair sample. Additional research is needed to identify factors that differentially affect the validity of both hair drug testing and self-report.
 ...
PMID:Comparison between self-report and hair analysis of illicit drug use in a community sample of middle-aged men. 1854 37