Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.15.1 (ACE)
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Human Gene/Protein
ACE 10.8
CPN4 10.8
angiotensin I-converting enzyme 10.8
THUMP domain containing 1 10.8
voltage-dependent L-type calcium channel alpha 1C subunit 10.8
ANG-3 10.8
kallikrein-related peptidase 9 10.8
Prostaglandin F2 receptor negative regulator 10.8
DCP 10.6
PDH 10.6
cytochrome b-245 beta polypeptide 9.8
b2 microglobulin 9.8
ANG-5 9.8
sperm autoantigenic protein 17 9.8
kininase I 9.3
Angiotensin-converting enzyme 9.3
succinyl-CoA:3-ketoacid-CoA transferase 9.2
SLC25A44 9.2
C7orf31 9.2
GALNTL6 9.2
threonine-tRNA ligase 9.2
AGTR1 9.0
ACTN3 8.9
membrane-bound aminopeptidase P 8.8
MLCK2 8.8
EPRAP 8.8
RENBP 8.8
activin A receptor, type IIB 8.8
cartilage intermediate layer protein 2 8.8
RENIN 8.6
PDHK2 8.6
angiotensin receptor 8.5
PDP2 8.5
ARB1 8.4
TTC39C 8.4
MRPL38 8.4
CEP68 8.4
PLEKHA2 8.4
pyruvate dehydrogenase alpha subunit 8.4
MRPL44 8.4
GHN 8.4
ETNK2 8.4
carboxypeptidase N 8.4
ACE2 8.4
ACEH 8.3
T2R1 8.3
ANG1 8.3
AGT 8.3
ECE2 8.3
MRPL11 8.2
collectrin 8.2
MMSDH 8.2
IQCK 8.2
PGBD1 8.2
RPH3A 8.2
MYG 8.2
acylase III 8.2
angiotensin II receptor 8.2
AGTR2 8.1
DCP1 8.1
alpha-actinin 3 8.1
ARB 8.0
angiotensin I converting enzyme 8.0
Angiotensin I converting enzyme 8.0
RNF25 8.0
PLEKHB1 8.0
ALG10 8.0
PP36 8.0
ATP8B3 8.0
THEM4 8.0
adducin 1 8.0
CGNL1 8.0
HSPA14 8.0
SSRC 8.0
UNC13B 8.0
carboxypeptidase O 8.0
zinc metallopeptidase 7.9
Angiotensin II receptor 7.9
aminopeptidase P 7.9
FCER1B 7.9
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Disease
bradykinin hypertension 10.8
Drug-induced malabsorption 10.8
Neonatal anuria 10.8
Instantaneous clearance 10.8
Drug-induced bullous pemphigoid 9.8
Small bowel angioedema 9.2
Residual proteinuria 9.2
Drug-induced urticaria 8.8
High altitude polycythemia 8.8
Splenic sarcoidosis 8.8
Drug-induced sexual dysfunction 8.8
Acute transmural myocardial infarction 8.8
Alimentary obesity 8.4
Post MI 8.4
Sarcoid uveitis 8.4
Acute left ventricular failure 8.3
Serum potassium increased 8.2
Potassium retention 8.2
Scleroderma renal crisis 8.2
Lymphocytic alveolitis 8.1
Bladder hypertrophy 8.0
Psychogenic cough 8.0
Renal magnesium wasting 8.0
Drug-induced hyperkalemia 7.8
High output heart failure 7.8
Lupus myocarditis 7.8
uncomplicated hypertension 7.7
Limited cutaneous systemic sclerosis 7.6
Acute nephritis 7.6
Nephroangiosclerosis 7.6
AKE 7.5
Intraoperative hypertension 7.4
IDDM10 7.3
Heerfordt's syndrome 7.2
Nephrotic range proteinuria 7.2
high renin hypertension 7.2
Erosive adenomatosis of the nipple 7.2
Ocular sarcoidosis 7.2
reninoma 7.1
PLAT 7.1
Unilateral renal artery stenosis 7.1
PDH deficiency 7.1
Chronic heart failure 7.0
Non-sustained ventricular tachycardia 7.0
Diastolic heart failure 7.0
renin-dependent hypertension 6.9
Systolic heart failure 6.9
Cytokine storm 6.9
Chronic iron overload 6.9
Decompensated heart failure 6.9
juxtaglomerular cell hyperplasia 6.9
Late pregnancy 6.9
microalbuminuria 6.7
Tracheopathia osteoplastica 6.7
renal scleroderma 6.7
Stable angina 6.7
IDDM8 6.7
Goldblatt 6.6
Age-associated memory impairment 6.6
Secondary hyperaldosteronism 6.6
Insulin allergy 6.5
Partington syndrome 6.5
Necrotizing sarcoid granulomatosis 6.5
Coombs positive hemolytic anemia 6.5
Schindler disease 6.5
systolic hypertension 6.5
hypercupremia 6.5
Hypertensive retinopathy 6.5
Hypertensive retinopathy 6.5
Renal scarring 6.4
Subcutaneous sarcoidosis 6.4
Radiation Syndrome 6.4
hypertensive heart disease 6.4
hyporeninemic hypoaldosteronism 6.4
Neurosarcoidosis 6.4
Hypersensitivity syndrome 6.4
HPA1 6.4
renal artery stenosis 6.3
Renovascular hypertension 6.3
Proteinuria 6.3
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Symptom
Drug-induced cough 10.8
Persistent dry cough 9.5
Gastrointestinal discomfort 7.2
Local swelling 7.1
axillary pain 6.6
postnasal drip 6.1
rales 5.8
Acute dyspnea 5.8
renal pain 5.7
Todd's paralysis 5.4
non-productive cough 5.2
stomach cramps 5.2
loss of taste 5.0
localized edema 5.0
pedal edema 5.0
cardiovascular impairment 5.0
abnormal reflex 5.0
PAIN 4.7
persistent cough 4.5
cough 4.5
Flare 4.3
chronic cough 4.2
growing pains 4.2
oliguria 4.1
Exercise intolerance 3.9
hematocolpos 3.8
angina 3.8
polyuria 3.4
physical exhaustion 3.4
dizziness 3.4
frequent urination 3.3
Neurologic symptoms 3.2
polydipsia 3.2
adipsia 3.2
exertional angina 3.2
Stiffness 3.1
atypical chest pain 3.0
Cushingoid 3.0
leg edema 3.0
Cushingoid 3.0
shortness of breath 2.9
disturbed balance 2.9
orthopnea 2.9
CSR 2.9
ACHE 2.9
Multimorbidity 2.9
Decreased activity 2.7
dyspnea 2.7
ketonuria 2.7
lassitude 2.6
hypoproteinemia 2.6
prostatism 2.6
pleuritic chest pain 2.6
asthenia 2.6
flushing 2.5
anosmia 2.5
loin pain 2.4
respiratory distress 2.3
hepatosplenomegaly 2.2
prostration 2.2
HSA 2.2
productive cough 2.2
mastalgia 2.2
night sweats 2.1
renal colic 2.1
hypertonia 2.1
livedo 2.0
loss of balance 1.9
muscle cramps 1.9
chest pain 1.9
Halo 1.9
blackout 1.9
exertional dyspnea 1.8
syncope 1.8
stomach pain 1.8
Catch 1.8
lightheadedness 1.8
splenomegaly 1.7
fever of unknown origin 1.7
myalgia 1.7
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Drug
Delapril hydrochloride 10.8
Disomotide 10.8
Libenzapril 10.8
Mirfentanil hydrochloride 10.8
Temocapril hydrochloride 10.8
Livact 10.2
Ecadotril 10.0
Cynt 9.8
Tartaric Acid 9.8
Ceronapril 9.8
Quinaprilat 9.5
Enalaprilat 9.4
Enalaprilat 9.4
Fosinopril sodium 9.4
Alacepril 9.4
Cilazapril 9.4
Benazeprilat 9.2
Pentopril 9.2
Fosinoprilat 9.2
INSPRA 9.2
Zosuquidar trihydrochloride 9.2
Eltrombopag olamine 9.2
Alosetron hydrochloride 9.2
Saralasin acetate 9.2
Omapatrilat 9.2
Ramipril 9.1
Volociximab 9.0
Accupro 9.0
Zofenopril calcium 9.0
Perindopril 8.9
Trandolapril 8.8
Canfosfamide hydrochloride 8.8
Accupril 8.8
Casopitant mesylate 8.8
Pazopanib hydrochloride 8.8
Dronedarone hydrochloride 8.8
Enalapril maleate 8.7
Lotrel 8.7
Captopril 8.6
3-Chlorophenol 8.4
Conivaptan hydrochloride 8.4
Concor 8.4
Atacand 8.4
Enzastaurin hydrochloride 8.4
Imidapril hydrochloride 8.4
Benazepril hydrochloride 8.3
Becatecarin 8.2
Teveten 8.2
Gantrisin 8.2
Guanadrel 8.2
Aliskiren 8.0
Monopril 8.0
Dibasic calcium phosphate 8.0
Dichlorophenamide 8.0
Atacand 8.0
Tandutinib 8.0
Apstatin 8.0
Apaziquone 8.0
Mecasermin rinfabate 8.0
Gantrisin 8.0
Aliskiren fumarate 7.8
Losartan potassium 7.7
2-Chlorophenol 7.7
Manidipine hydrochloride 7.6
Teveten 7.6
Sulotroban 7.4
Atomoxetine hydrochloride 7.4
Ziprasidone hydrochloride 7.4
Vernakalant hydrochloride 7.3
Toborinone 7.3
Lercanidipine 7.2
Valsartan 7.1
Fingolimod hydrochloride 7.1
Fosamprenavir calcium 7.1
Z-Pro-Prolinal 7.1
Atazanavir sulfate 7.0
Camostat mesilate 7.0
Norvasc 7.0
Inspra 7.0
Alvocidib 7.0
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Enzyme
ACE 10.8
PDH 10.7
dipeptidyl carboxyhydrolase 10.2
aminopeptidase W 9.6
oligopeptidase A 9.3
peptide hormone inactivating endopeptidase 9.2
carboxypeptidase Taq 8.8
dipeptidyl-dipeptidase 8.8
CPN 8.4
aminopeptidase P 8.2
D-2-haloacid dehalogenase 8.2
AGT 8.1
BCKDH 7.8
thimet oligopeptidase 7.6
3beta-HSDH 7.5
arogenate dehydrogenase 7.5
neurolysin 7.4
fRMsr 7.3
angiotensin-converting enzyme 2 7.3
renin 7.2
chymase 6.9
2,4-dichlorophenol hydroxylase 6.9
carboxylate reductase 6.6
XMT 6.5
bacillolysin 6.4
CD10 6.3
MDH 6.2
aminopeptidase B 6.2
prephenate dehydrogenase 6.2
kallikrein 6.1
MDH 6.1
15-hydroxyprostaglandin dehydrogenase 6.1
endothelin-converting enzyme 6.0
aminopeptidase A 6.0
pyruvate dehydrogenase 5.9
pyruvate dehydrogenase 5.9
serum carnosinase 5.9
prephenate dehydrogenase 5.9
XMT 5.9
2-oxoglutarate decarboxylase 5.9
methylmalonate-semialdehyde dehydrogenase 5.8
tripeptidase 5.7
tissue kallikrein 5.7
pyruvate dehydrogenase 5.7
carboxypeptidase B 5.7
thermolysin 5.6
enkephalinase B 5.6
prolyl endopeptidase 5.5
dipeptidyl peptidase IV 5.5
aspartyl aminopeptidase 5.5
PDK1 5.5
chloromuconate cycloisomerase 5.4
carnosinase 5.4
bleomycin hydrolase 5.4
carboxypeptidase A 5.3
carboxypeptidase E 5.3
pyruvate dehydrogenase phosphatase 5.3
pyroglutamyl peptidase II 5.2
PRA 5.2
actinidin 5.2
maleylacetate reductase 5.2
glutamine transaminase K 5.1
lipoate acetyltransferase 5.1
electron transfer flavoprotein dehydrogenase 5.0
caricain 5.0
CPM 5.0
SCP 4.9
nicotianamine synthase 4.9
GP-I 4.9
CD13 4.8
PepX 4.8
cathepsin V 4.8
cathepsin C 4.8
C1 esterase 4.7
glucose-6-phosphate dehydrogenase 4.7
serralysin 4.6
MDP 4.6
glycogen synthase phosphatase 4.6
LipB 4.5
octopine dehydrogenase 4.5
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Compound
C13H15NO6 10.8
C15H10N2O5 10.8
C12H13NO6 10.8
C12H17NO5 10.8
C13H15NO6 10.8
C12H17NO5 10.8
C13H15NO6 10.8
C12H17NO5 10.8
C15H10N2O5 10.8
C13H15NO6 10.8
C12H13NO6 10.8
L-Aspartyl-L-phenylalanine 10.8
C15H10N2O5 10.8
C13H15NO6 10.8
C12H17NO5 10.8
C12H17NO5 10.8
C12H13NO6 10.8
C15H10N2O5 10.8
C13H15NO6 10.8
Verticine 10.8
C12H17NO5 10.8
C12H13NO6 10.8
C13H15NO6 10.8
C13H15NO6 10.8
C13H15NO6 10.8
C12H17NO5 10.8
C12H17NO5 10.8
C12H17NO5 10.8
C13H15NO6 10.8
C15H10N2O5 10.8
C13H15NO6 10.8
C13H15NO6 10.8
C12H17NO5 10.8
C13H15NO6 10.8
C12H13NO6 10.8
C12H13NO6 10.8
C12H13NO6 10.8
DCP 10.7
C13H15NO6 10.2
C13H15NO6 10.2
PDH 10.2
DCP 10.1
Teprotide 9.9
C13H15NO6 9.8
C15H10N2O5 9.8
Neoastilbin 9.8
C13H15NO6 9.8
1,3-dichloro-2-propanol 9.7
Benazepril 9.5
3-pyridinesulfonamide 9.4
C13H15NO6 9.4
Enalaprilat 9.4
Fosinopril 9.3
2-chloroacrylic acid 9.2
1,1-Dichloropropene 9.2
C25H45NO 9.2
C15H10N2O5 9.2
C15H10N2O5 9.2
C12H15NO5 9.2
(+)-Syringaresinol 9.2
Perindopril erbumine 9.2
2,5-DCP 9.1
Perindopril 9.1
Quinapril 9.0
Enalapril 8.9
2,4-dichlorophenol 8.9
2,3-dichloro-1-propene 8.8
Quinapril hydrochloride 8.8
LPR 8.5
3,5-dichlorophenol 8.5
Angiotensin I 8.5
Moexipril 8.4
3-isoquinolinecarboxylic acid 8.4
C10H7NO2 8.4
C10H7NO2 8.4
3,4-dichlorophenol 8.3
Ebelactone B 8.3
Phenylacetylglutamine 8.3
2,3-dichlorophenol 8.3
1,2-dichloropropane 8.3
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