Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.15.1 (
ACE
)
18,300
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
ACE
8555
renin
3111
angiotensin II
2246
Ang II
1432
DCP
1221
Sep
1168
bradykinin
1088
Angiotensin-converting enzyme
1015
angiotensin I-converting enzyme
911
angiotensin receptor
815
insulin
738
calcium channel
728
PDH
656
Mol
517
angiotensin II receptor
514
AT1
513
angiotensinogen
410
neutral endopeptidase
342
albumin
341
collagen
312
ACE2
284
SARS
248
Renin
226
kallikrein
211
angiotensin-converting enzyme 2
190
peptidase
173
chronic renal failure
165
Mal
161
ARB
154
substance P
149
AT1R
149
AT2
144
nitric oxide synthase
144
ANG
142
cytokine
130
vasopressin
130
pyruvate dehydrogenase
128
hemoglobin
127
AGT
120
mineralocorticoid receptor
119
atrial natriuretic peptide
115
TCP
112
Pol
110
endothelin-1
109
TNF
109
glucose-6-phosphate dehydrogenase
108
aminopeptidase
104
ATP
100
HDL
99
superoxide dismutase
97
GSH
96
chymase
94
natriuretic peptide
93
GFR
90
DBP
87
lactate dehydrogenase
86
LDH
86
SBP
84
catalase
82
C18
81
NMR
81
vascular endothelium
77
She
77
gut
76
MTHFR
76
bradykinin B2 receptor
76
plasminogen activator inhibitor-1
75
angiotensin I converting enzyme
75
alanyl
73
vascular endothelial growth factor
73
eNOS
73
membrane-bound
71
alkaline phosphatase
71
SDS
68
ATPase
68
casein
67
NEP
67
cyclooxygenase
66
APOE
66
MRI
64
more...
Disease
hypertension
4185
heart failure
1848
diabetes
1466
myocardial infarction
828
renal disease
828
congestive heart failure
793
proteinuria
659
essential hypertension
619
stroke
581
cardiovascular disease
575
ATM
514
diabetic nephropathy
477
atherosclerosis
454
sarcoidosis
441
renal failure
433
ventricular hypertrophy
419
coronary artery disease
389
type 2 diabetes
361
cancer
339
myocardial ischemia
300
SARS
290
obesity
277
acute myocardial infarction
266
chronic renal failure
260
microalbuminuria
245
coronary heart disease
232
ischemia
229
tumor
201
Alzheimer's disease
182
renal insufficiency
179
glomerulosclerosis
172
cardiomyopathy
143
metabolic syndrome
141
type 1 diabetes
132
depression
130
renal artery stenosis
129
hyperglycemia
128
dementia
121
heart disease
120
dilated cardiomyopathy
118
anemia
117
TCP
112
vascular disease
109
renal impairment
107
hypercholesterolemia
104
hyperlipidemia
103
SEM
101
GSH
97
acute renal failure
96
plaque
95
asthma
95
dyslipidemia
94
NAME
89
nephrotic syndrome
88
systolic hypertension
87
pneumonia
87
lymphadenopathy
82
pulmonary hypertension
76
retinopathy
76
cognitive impairment
75
Proteinuria
74
SDS
68
hyperinsulinemia
66
cold
64
glomerulonephritis
63
IgA nephropathy
62
chronic obstructive pulmonary disease
59
glucose intolerance
57
cirrhosis
57
PSS
57
sepsis
55
aldosteronism
55
HIV
54
unstable angina
52
sepsis
51
myocarditis
51
pulmonary edema
50
scleroderma
50
diabetic retinopathy
49
pulmonary fibrosis
47
more...
Symptom
cough
308
angina
166
dyspnea
103
pain
103
headache
102
anesthesia
83
diarrhea
65
fatigue
59
dizziness
57
respiratory distress
55
weakness
45
overweight
40
chest pain
38
vomiting
37
abdominal pain
33
nausea
32
seizures
29
shortness of breath
23
chronic cough
21
flushing
21
rales
20
starvation
20
splenomegaly
19
polyuria
19
syncope
19
oliguria
18
erythema
18
Welt
16
exhaustion
15
thinning
15
collapse
15
anorexia
14
discomfort
14
discomfort
14
analgesia
14
constipation
14
arthralgia
12
acidity
12
myalgia
12
hepatosplenomegaly
12
polydipsia
12
functional recovery
11
sleepiness
11
agitation
11
regurgitation
10
postnasal drip
10
vertigo
10
asthenia
9
ataxia
9
hepatomegaly
9
Ill
8
hypercapnia
8
nausea and vomiting
8
HSA
8
tremor
8
hypothermia
8
persistent cough
8
spasm
8
hyperoxia
8
cachexia
7
exertional dyspnea
7
loss of taste
7
paresthesia
6
non-productive cough
6
hemoptysis
6
anosmia
5
apathy
5
Stiffness
5
ENT
5
wheezing
5
dystonia
4
exertional angina
4
fever of unknown origin
4
spasticity
4
hoarseness
4
acute stress
4
pedal edema
4
numbness
4
hypotonia
4
acute abdomen
4
more...
Drug
Cardiovasc
553
Captopril
521
Angiotensin II
300
Ramipril
133
Perindopril
93
lysine
62
Enalaprilat
60
Enalaprilat
59
nitroglycerin
53
Cilazapril
52
Dial
51
Monit
49
NADH
44
Dermatol
44
Aliskiren
39
Valsartan
38
ROS
35
CSF
34
vitamin E
34
MAP
32
Trandolapril
31
Asn
29
Indomethacin
29
Digitalis
28
citric acid
25
ascorbate
24
Omapatrilat
24
Nephron
22
Hydrochlorothiazide
19
PTH
18
TiO2
17
Albumin
17
CTX
16
ETA
16
Atenolol
14
Fraction
13
MRC
13
Nephron
13
Enalapril maleate
13
PCP
12
Asthma
12
lactose
11
niacin
11
L-tyrosine
11
THF
11
ENT
10
Alacepril
10
Ethanol
10
Triclosan
10
Felodipine
10
caffeine
9
Olmesartan
9
Phosphoramidon
9
ADM
9
Leaf
9
Aprotinin
9
ZnO
9
EPA
8
Gel
8
ROC
8
G-CSF
8
ICI
7
Losartan potassium
7
Bifidobacterium
7
IL-2
7
Adriamycin
7
Methyldopa
7
Quinaprilat
7
Simvastatin
7
Bosentan
7
DFP
7
FAD
7
Bosentan
7
Bestatin
6
dibasic calcium phosphate
6
ZnCl2
5
TTC
5
Lercanidipine
5
Fosinopril sodium
5
ZnCl2
5
more...
Enzyme
ACE
18300
renin
3111
PDH
656
CD10
451
kallikrein
241
pyruvate dehydrogenase
164
trypsin
136
ERK
134
superoxide dismutase
128
pyruvate dehydrogenase
123
pyruvate dehydrogenase
123
AGT
120
glucose-6-phosphate dehydrogenase
113
catalase
101
lactate dehydrogenase
96
angiotensin-converting enzyme 2
93
chymase
93
CPN
87
pepsin
78
NO synthase
78
mitogen-activated protein kinase
74
ATPase
72
alkaline phosphatase
72
NADPH oxidase
67
lysozyme
63
acetylcholinesterase
63
peroxidase
60
CD13
59
PDK1
57
NADPH oxidase
54
thermolysin
54
phosphodiesterase
53
protein kinase C
52
tissue plasminogen activator
51
glutathione peroxidase
49
chymotrypsin
48
thrombin
47
subtilisin
47
alanine aminotransferase
47
papain
46
creatine kinase
44
focal adhesion kinase
44
malate dehydrogenase
44
protein kinase
43
dipeptidyl peptidase IV
43
collagenase
40
tissue kallikrein
38
aminopeptidase P
37
MDP
37
PRA
35
MDH
34
MDH
34
glutathione reductase
31
aspartate aminotransferase
31
acid phosphatase
31
glutathione S-transferase
31
cathepsin D
30
proteasome
30
guanylate cyclase
30
MAP
30
CAD
29
CAD
29
CAD
29
alcohol dehydrogenase
27
reverse transcriptase
27
caspase-3
27
NOS
26
gamma-glutamyl transpeptidase
25
carbonic anhydrase
25
ACS
24
15-hydroxyprostaglandin dehydrogenase
24
xanthine oxidase
23
succinate dehydrogenase
23
carboxypeptidase A
23
endothelin-converting enzyme
23
methylenetetrahydrofolate reductase
22
methylenetetrahydrofolate reductase
22
AMP-activated protein kinase
22
thimet oligopeptidase
22
prolyl endopeptidase
21
more...
Compound
acetate
8647
Clin
1466
Dec
1408
calcium
1271
DCP
1153
DCP
1153
aldosterone
1102
sodium
959
water
955
Angiotensin II
784
glucose
719
PDH
658
creatinine
588
Ang II
560
oxygen
527
Cardiol
508
salt
486
nitric oxide
425
potassium
417
2,4-dichlorophenol
401
arginine
393
DNA
382
Phe
278
Enalapril
246
leucine
230
phosphate
202
tyrosine
199
alanine
198
zinc
195
proline
190
Gly
186
lysine
172
noradrenaline
154
Bradykinin
151
nitrogen
144
prostacyclin
136
hydrogen
135
Ile
131
TCP
129
His
123
EDTA
121
EDTA
120
LPR
117
phenol
116
urea
116
TCP
115
ethanol
113
TCP
112
TCP
112
iron
111
TNF
109
Losartan
102
ATP
100
GSH
97
sulfate
97
GSH
97
methionine
94
nitrate
91
Perindopril
90
DBP
89
ASA
89
DBP
88
Insulin
87
serine
85
acetonitrile
83
His-Leu
79
methanol
79
Asp
74
cGMP
71
acetic acid
70
SDS
70
cysteine
69
4-chlorophenol
67
threonine
64
DPPH
62
Hoe
62
2,4,6-trichlorophenol
61
CO2
60
Enalaprilat
60
2,4,6-trichlorophenol
59
more...