Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.15.1 (ACE)
18,300 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ACE 8555
renin 3111
angiotensin II 2246
Ang II 1432
DCP 1221
Sep 1168
bradykinin 1088
Angiotensin-converting enzyme 1015
angiotensin I-converting enzyme 911
angiotensin receptor 815
insulin 738
calcium channel 728
PDH 656
Mol 517
angiotensin II receptor 514
AT1 513
angiotensinogen 410
neutral endopeptidase 342
albumin 341
collagen 312
ACE2 284
SARS 248
Renin 226
kallikrein 211
angiotensin-converting enzyme 2 190
peptidase 173
chronic renal failure 165
Mal 161
ARB 154
substance P 149
AT1R 149
AT2 144
nitric oxide synthase 144
ANG 142
cytokine 130
vasopressin 130
pyruvate dehydrogenase 128
hemoglobin 127
AGT 120
mineralocorticoid receptor 119
atrial natriuretic peptide 115
TCP 112
Pol 110
endothelin-1 109
TNF 109
glucose-6-phosphate dehydrogenase 108
aminopeptidase 104
ATP 100
HDL 99
superoxide dismutase 97
GSH 96
chymase 94
natriuretic peptide 93
GFR 90
DBP 87
lactate dehydrogenase 86
LDH 86
SBP 84
catalase 82
C18 81
NMR 81
vascular endothelium 77
She 77
gut 76
MTHFR 76
bradykinin B2 receptor 76
plasminogen activator inhibitor-1 75
angiotensin I converting enzyme 75
alanyl 73
vascular endothelial growth factor 73
eNOS 73
membrane-bound 71
alkaline phosphatase 71
SDS 68
ATPase 68
casein 67
NEP 67
cyclooxygenase 66
APOE 66
MRI 64
more...
Disease
hypertension 4185
heart failure 1848
diabetes 1466
myocardial infarction 828
renal disease 828
congestive heart failure 793
proteinuria 659
essential hypertension 619
stroke 581
cardiovascular disease 575
ATM 514
diabetic nephropathy 477
atherosclerosis 454
sarcoidosis 441
renal failure 433
ventricular hypertrophy 419
coronary artery disease 389
type 2 diabetes 361
cancer 339
myocardial ischemia 300
SARS 290
obesity 277
acute myocardial infarction 266
chronic renal failure 260
microalbuminuria 245
coronary heart disease 232
ischemia 229
tumor 201
Alzheimer's disease 182
renal insufficiency 179
glomerulosclerosis 172
cardiomyopathy 143
metabolic syndrome 141
type 1 diabetes 132
depression 130
renal artery stenosis 129
hyperglycemia 128
dementia 121
heart disease 120
dilated cardiomyopathy 118
anemia 117
TCP 112
vascular disease 109
renal impairment 107
hypercholesterolemia 104
hyperlipidemia 103
SEM 101
GSH 97
acute renal failure 96
plaque 95
asthma 95
dyslipidemia 94
NAME 89
nephrotic syndrome 88
systolic hypertension 87
pneumonia 87
lymphadenopathy 82
pulmonary hypertension 76
retinopathy 76
cognitive impairment 75
Proteinuria 74
SDS 68
hyperinsulinemia 66
cold 64
glomerulonephritis 63
IgA nephropathy 62
chronic obstructive pulmonary disease 59
glucose intolerance 57
cirrhosis 57
PSS 57
sepsis 55
aldosteronism 55
HIV 54
unstable angina 52
sepsis 51
myocarditis 51
pulmonary edema 50
scleroderma 50
diabetic retinopathy 49
pulmonary fibrosis 47
more...
Symptom
cough 308
angina 166
dyspnea 103
pain 103
headache 102
anesthesia 83
diarrhea 65
fatigue 59
dizziness 57
respiratory distress 55
weakness 45
overweight 40
chest pain 38
vomiting 37
abdominal pain 33
nausea 32
seizures 29
shortness of breath 23
chronic cough 21
flushing 21
rales 20
starvation 20
splenomegaly 19
polyuria 19
syncope 19
oliguria 18
erythema 18
Welt 16
exhaustion 15
thinning 15
collapse 15
anorexia 14
discomfort 14
discomfort 14
analgesia 14
constipation 14
arthralgia 12
acidity 12
myalgia 12
hepatosplenomegaly 12
polydipsia 12
functional recovery 11
sleepiness 11
agitation 11
regurgitation 10
postnasal drip 10
vertigo 10
asthenia 9
ataxia 9
hepatomegaly 9
Ill 8
hypercapnia 8
nausea and vomiting 8
HSA 8
tremor 8
hypothermia 8
persistent cough 8
spasm 8
hyperoxia 8
cachexia 7
exertional dyspnea 7
loss of taste 7
paresthesia 6
non-productive cough 6
hemoptysis 6
anosmia 5
apathy 5
Stiffness 5
ENT 5
wheezing 5
dystonia 4
exertional angina 4
fever of unknown origin 4
spasticity 4
hoarseness 4
acute stress 4
pedal edema 4
numbness 4
hypotonia 4
acute abdomen 4
more...
Drug
Cardiovasc 553
Captopril 521
Angiotensin II 300
Ramipril 133
Perindopril 93
lysine 62
Enalaprilat 60
Enalaprilat 59
nitroglycerin 53
Cilazapril 52
Dial 51
Monit 49
NADH 44
Dermatol 44
Aliskiren 39
Valsartan 38
ROS 35
CSF 34
vitamin E 34
MAP 32
Trandolapril 31
Asn 29
Indomethacin 29
Digitalis 28
citric acid 25
ascorbate 24
Omapatrilat 24
Nephron 22
Hydrochlorothiazide 19
PTH 18
TiO2 17
Albumin 17
CTX 16
ETA 16
Atenolol 14
Fraction 13
MRC 13
Nephron 13
Enalapril maleate 13
PCP 12
Asthma 12
lactose 11
niacin 11
L-tyrosine 11
THF 11
ENT 10
Alacepril 10
Ethanol 10
Triclosan 10
Felodipine 10
caffeine 9
Olmesartan 9
Phosphoramidon 9
ADM 9
Leaf 9
Aprotinin 9
ZnO 9
EPA 8
Gel 8
ROC 8
G-CSF 8
ICI 7
Losartan potassium 7
Bifidobacterium 7
IL-2 7
Adriamycin 7
Methyldopa 7
Quinaprilat 7
Simvastatin 7
Bosentan 7
DFP 7
FAD 7
Bosentan 7
Bestatin 6
dibasic calcium phosphate 6
ZnCl2 5
TTC 5
Lercanidipine 5
Fosinopril sodium 5
ZnCl2 5
more...
Enzyme
ACE 18300
renin 3111
PDH 656
CD10 451
kallikrein 241
pyruvate dehydrogenase 164
trypsin 136
ERK 134
superoxide dismutase 128
pyruvate dehydrogenase 123
pyruvate dehydrogenase 123
AGT 120
glucose-6-phosphate dehydrogenase 113
catalase 101
lactate dehydrogenase 96
angiotensin-converting enzyme 2 93
chymase 93
CPN 87
pepsin 78
NO synthase 78
mitogen-activated protein kinase 74
ATPase 72
alkaline phosphatase 72
NADPH oxidase 67
lysozyme 63
acetylcholinesterase 63
peroxidase 60
CD13 59
PDK1 57
NADPH oxidase 54
thermolysin 54
phosphodiesterase 53
protein kinase C 52
tissue plasminogen activator 51
glutathione peroxidase 49
chymotrypsin 48
thrombin 47
subtilisin 47
alanine aminotransferase 47
papain 46
creatine kinase 44
focal adhesion kinase 44
malate dehydrogenase 44
protein kinase 43
dipeptidyl peptidase IV 43
collagenase 40
tissue kallikrein 38
aminopeptidase P 37
MDP 37
PRA 35
MDH 34
MDH 34
glutathione reductase 31
aspartate aminotransferase 31
acid phosphatase 31
glutathione S-transferase 31
cathepsin D 30
proteasome 30
guanylate cyclase 30
MAP 30
CAD 29
CAD 29
CAD 29
alcohol dehydrogenase 27
reverse transcriptase 27
caspase-3 27
NOS 26
gamma-glutamyl transpeptidase 25
carbonic anhydrase 25
ACS 24
15-hydroxyprostaglandin dehydrogenase 24
xanthine oxidase 23
succinate dehydrogenase 23
carboxypeptidase A 23
endothelin-converting enzyme 23
methylenetetrahydrofolate reductase 22
methylenetetrahydrofolate reductase 22
AMP-activated protein kinase 22
thimet oligopeptidase 22
prolyl endopeptidase 21
more...
Compound
acetate 8647
Clin 1466
Dec 1408
calcium 1271
DCP 1153
DCP 1153
aldosterone 1102
sodium 959
water 955
Angiotensin II 784
glucose 719
PDH 658
creatinine 588
Ang II 560
oxygen 527
Cardiol 508
salt 486
nitric oxide 425
potassium 417
2,4-dichlorophenol 401
arginine 393
DNA 382
Phe 278
Enalapril 246
leucine 230
phosphate 202
tyrosine 199
alanine 198
zinc 195
proline 190
Gly 186
lysine 172
noradrenaline 154
Bradykinin 151
nitrogen 144
prostacyclin 136
hydrogen 135
Ile 131
TCP 129
His 123
EDTA 121
EDTA 120
LPR 117
phenol 116
urea 116
TCP 115
ethanol 113
TCP 112
TCP 112
iron 111
TNF 109
Losartan 102
ATP 100
GSH 97
sulfate 97
GSH 97
methionine 94
nitrate 91
Perindopril 90
DBP 89
ASA 89
DBP 88
Insulin 87
serine 85
acetonitrile 83
His-Leu 79
methanol 79
Asp 74
cGMP 71
acetic acid 70
SDS 70
cysteine 69
4-chlorophenol 67
threonine 64
DPPH 62
Hoe 62
2,4,6-trichlorophenol 61
CO2 60
Enalaprilat 60
2,4,6-trichlorophenol 59
more...