Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.15.1 (
ACE
)
18,300
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
ACE
8555
renin
3111
angiotensin II
2246
Ang II
1432
DCP
1221
Sep
1168
bradykinin
1088
Angiotensin-converting enzyme
1015
angiotensin I-converting enzyme
911
angiotensin receptor
815
insulin
738
calcium channel
728
PDH
656
Mol
517
angiotensin II receptor
514
AT1
513
angiotensinogen
410
neutral endopeptidase
342
albumin
341
collagen
312
ACE2
284
SARS
248
Renin
226
kallikrein
211
angiotensin-converting enzyme 2
190
peptidase
173
chronic renal failure
165
Mal
161
ARB
154
substance P
149
AT1R
149
AT2
144
nitric oxide synthase
144
ANG
142
vasopressin
130
cytokine
130
pyruvate dehydrogenase
128
hemoglobin
127
AGT
120
mineralocorticoid receptor
119
more...
Disease
hypertension
4185
heart failure
1848
diabetes
1466
myocardial infarction
828
renal disease
828
congestive heart failure
793
proteinuria
659
essential hypertension
619
stroke
581
cardiovascular disease
575
ATM
514
diabetic nephropathy
477
atherosclerosis
454
sarcoidosis
441
renal failure
433
ventricular hypertrophy
419
coronary artery disease
389
type 2 diabetes
361
cancer
339
myocardial ischemia
300
SARS
290
obesity
277
acute myocardial infarction
266
chronic renal failure
260
microalbuminuria
245
coronary heart disease
232
ischemia
229
tumor
201
Alzheimer's disease
182
renal insufficiency
179
glomerulosclerosis
172
cardiomyopathy
143
metabolic syndrome
141
type 1 diabetes
132
depression
130
renal artery stenosis
129
hyperglycemia
128
dementia
121
heart disease
120
dilated cardiomyopathy
118
more...
Symptom
cough
308
angina
166
dyspnea
103
pain
103
headache
102
anesthesia
83
diarrhea
65
fatigue
59
dizziness
57
respiratory distress
55
weakness
45
overweight
40
chest pain
38
vomiting
37
abdominal pain
33
nausea
32
seizures
29
shortness of breath
23
flushing
21
chronic cough
21
rales
20
starvation
20
splenomegaly
19
polyuria
19
syncope
19
erythema
18
oliguria
18
Welt
16
collapse
15
exhaustion
15
thinning
15
analgesia
14
constipation
14
anorexia
14
discomfort
14
discomfort
14
hepatosplenomegaly
12
myalgia
12
acidity
12
arthralgia
12
more...
Drug
Cardiovasc
553
Captopril
521
Angiotensin II
300
Ramipril
133
Perindopril
93
lysine
62
Enalaprilat
60
Enalaprilat
59
nitroglycerin
53
Cilazapril
52
Dial
51
Monit
49
NADH
44
Dermatol
44
Aliskiren
39
Valsartan
38
ROS
35
vitamin E
34
CSF
34
MAP
32
Trandolapril
31
Asn
29
Indomethacin
29
Digitalis
28
citric acid
25
Omapatrilat
24
ascorbate
24
Nephron
22
Hydrochlorothiazide
19
PTH
18
TiO2
17
Albumin
17
ETA
16
CTX
16
Atenolol
14
Enalapril maleate
13
MRC
13
Nephron
13
Fraction
13
PCP
12
more...
Enzyme
ACE
18300
renin
3111
PDH
656
CD10
451
kallikrein
241
pyruvate dehydrogenase
164
trypsin
136
ERK
134
superoxide dismutase
128
pyruvate dehydrogenase
123
pyruvate dehydrogenase
123
AGT
120
glucose-6-phosphate dehydrogenase
113
catalase
101
lactate dehydrogenase
96
angiotensin-converting enzyme 2
93
chymase
93
CPN
87
pepsin
78
NO synthase
78
mitogen-activated protein kinase
74
alkaline phosphatase
72
ATPase
72
NADPH oxidase
67
acetylcholinesterase
63
lysozyme
63
peroxidase
60
CD13
59
PDK1
57
thermolysin
54
NADPH oxidase
54
phosphodiesterase
53
protein kinase C
52
tissue plasminogen activator
51
glutathione peroxidase
49
chymotrypsin
48
subtilisin
47
thrombin
47
alanine aminotransferase
47
papain
46
more...
Compound
acetate
8647
Clin
1466
Dec
1408
calcium
1271
DCP
1153
DCP
1153
aldosterone
1102
sodium
959
water
955
Angiotensin II
784
glucose
719
PDH
658
creatinine
588
Ang II
560
oxygen
527
Cardiol
508
salt
486
nitric oxide
425
potassium
417
2,4-dichlorophenol
401
arginine
393
DNA
382
Phe
278
Enalapril
246
leucine
230
phosphate
202
tyrosine
199
alanine
198
zinc
195
proline
190
Gly
186
lysine
172
noradrenaline
154
Bradykinin
151
nitrogen
144
prostacyclin
136
hydrogen
135
Ile
131
TCP
129
His
123
more...