Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.15.1 (
ACE
)
18,300
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long-term glycaemic control measured by glycosylated haemoglobin concentration was compared in hypertensive
NIDD
's taking placebo, alpha-blockers, beta-blockers (alone and in combination) and an
ACE
inhibitor (enalapril) each for 4 months. Alpha-blockade caused no deterioration in long-term glycaemic control in
NIDD
's. Beta-blockers caused a deterioration in glycaemic control in
NIDD
's (with some adverse effects on lipid profile). This was especially apparent with the lipophilic beta-blocker P. Concurrent use of an alpha-blocker with a beta-blocker prevents the deterioration due to beta-blockade. The
ACE
inhibitor, enalapril caused an improvement in long-term glycaemic control without alteration of lipid control in
NIDD
's.
...
PMID:Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics. 197 46
