Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.15.1 (ACE)
 18,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Significantly higher values of systolic and diastolic arterial blood pressure as compared to the corresponding control group was found in a group of 31 patients with polycystic ovary syndrome (PCO) of age between 22 and 42 years (mean 34 years). It was demonstrated that the activity of the enzyme converting angiotensin I to angiotensin II (angiotensin converting enzyme, ACE) as determined by the spectrofluorometric method of Friedland and Silverstein did not differ significantly from that found in the control group. No significant correlation was also found between the ACE activity and the concentrations of testosterone, androstenedione, dehydroepiandrosterone, LH, FSH, prolactin and estradiol both in the patients and in the control group.
Endokrynol Pol 1993
PMID:[Activity of the enzyme converting angiotensin I to angiotensin II (ACE) in patients with polycystic ovary syndrome]. 805 88

Plasma renin activity, blood aldosterone levels and ANP secretion have been studied in 15 patients with the acute non-inflammatory renal insufficiency prior to and after ACE blockade with captopril. The above parameters were investigated at rest and in water immersion. Captopril significantly enhanced plasma renin activity in both examined groups, and decreased blood serum aldosterone levels but only in healthy subjects. Captopril had no effect on serum ANP levels. Results did not reveal close correlation between ANP release and renin-angiotensin-aldosterone system activity in both healthy subjects and patients with the acute non-inflammatory renal insufficiency.
Pol Tyg Lek
PMID:[Function of the renin-angiotensin-aldosterone system and atrial natriuretic peptide secretion in patients with acute non-inflammatory renal insufficiency]. 817 Aug 13

Differential value of ACE activity and acid alpha 1-glycoprotein was evaluated in the selected liver and biliary tract diseases. The study involved 75 patients divided into 4 subgroups, according to the character of their disease: patients with the acute viral hepatitis, chronic viral hepatitis, liver cirrhosis, and cholelithiasis. It was found that ACE activity was significantly increased in all pathologies involving liver parenchyma, and normal in patients with extrahepatic cholestasis. It was also shown that simultaneous assays of ACE and acid < alpha 1-glycoprotein may serve as a sensitive test differentiating jaundice in parenchymal hepatic diseases from that in the course of extrahepatic pathology.
Pol Tyg Lek
PMID:[Activity of angiotensin converting enzyme I and levels of acid alpha glycoprotein in selected liver and biliary tract diseases]. 823 40

Epidemiological studies have revealed, that elevated blood pressure is in diabetics 1.5-3.0-times more frequent that in general population. It is one of the most important factors increasing the morbidity and mortality due to small and big arteries disease. Hypotensive therapy should be commenced in diabetic persons earlier than in patients without diabetes mellitus. In many such diabetic patients blood pressure normalization could be obtained by dietary adaptations and metabolic compensation. In more advanced cases pharmacological treatment should be undertaken. When selecting the drug for a diabetic person one has to balance between positive and adverse actions. The drugs of the first choice are the ACE inhibitors, drugs blocking the slow calcium channel and alpha 1-adrenergic receptors, because they do not influence negatively the carbohydrate and lipid metabolism. On contrary, prazosin and ACE inhibitors increase the tissue sensitivity to insulin. The latter group decrease also intraglomerular pressure and albuminuria. As a routine the treatment begins with small, testing dose of a single hypotensive drug. The dosage may be increased slowly up to the average dose level. If this manipulation does not permit normalization of blood pressure one may combine 2 or 3 hypotensive drugs. Selection of the drug and of its dose rely also on the type and intensity of late diabetic complications--at first nephropathy and autonomic neuropathy.
Pol Tyg Lek
PMID:[Principles of hypotension treatment in patients with diabetes]. 836 76

In type I diabetic patients association has been found between the insertion/deletion (I/D) polymorphism in the gene of angiotensin converting enzyme and the presence of diabetic nephropathy. The aim of that study was to assess this association in a cohort of type II diabetics. We examined 109 patients of more than 10 years duration of type II diabetes. Nephropathy (defined as at least confirmed albuminuria > 30 mg/24h) was present in 37 subjects. The I/D polymorphism was analyzed with PCR technique. Allele frequencies in the overall diabetic population did not differ significantly from the normal population. Distribution of genotypes was not significantly different between examined patients with and those without nephropathy. We conclude that the distribution of ACE gene polymorphism is similar in diabetic subjects and in general population and there is not association between I/D polymorphism and nephropathy in type II diabetic patients.
Pol Arch Med Wewn 1995 Sep
PMID:[Does an association between angiotensin I converting enzyme gene polymorphism and the prevalence of diabetic nephropathy in patients with diabetes type II exist?]. 859 58

Analysis is presented of polymorphism of gene specifying angiotensin converting enzyme in Polish population and its comparison with results obtained for control group. Insertion/deletion polymorphism was detected by polymerase chain reaction. Frequencies of I/D alleles in control group were similar to those reported in French population but different frequencies were observed in patients with myocardial infarction.
Pol Arch Med Wewn 1996 Jan
PMID:[Analysis of angiotensin converting enzyme (ACE) polymorphism in patients with myocardial infarction in the Polish population]. 867 93

For many years a genetic predisposition to sarcoidosis has been considered likely, however no convincing evidence have ever been found. We report histologically proven cases of sarcoidosis in two brothers. Initially, the case of sarcoidosis was diagnosed in a 36-year-old male patient (II stage of radiological lesions) and 4 years later the case of sarcoidosis was diagnosed in 28-year-old younger brother of the first patient (III stage). The brothers did not live together but, in the same neighbourhood. We evaluated the active evolution of a disease by clinical, radiological, including high resolution computed tomography and functional methods as well as by evaluating cellular and soluble components of bronchoalveolar lavage fluid (angiotensin converting enzyme, protein, phospholipids). The above constitutes the first report on familial sarcoidosis recorded in Poland.
Pneumonol Alergol Pol 1996
PMID:[Familial sarcoidosis. Report of 2 cases in brothers]. 892 89

The aim of this study was to compare the potential antithrombotic action of captopril (angiotensin converting enzyme inhibitor) and losartan (a selective AT1 receptor antagonist) after their chronic administration in a model of venous thrombosis in rats. Captopril significantly reduced the incidence of venous thrombosis (67% vs 14%; p < 0.05) and both drugs markedly reduced the weight of thrombus. At the same time the platelet aggregation was reduced only in rats treated with losartan (100 +/- 7% vs 52 +/- 11%; p < 0.001). The mean blood pressure dropped only after losartan administration. We observed no changes in "transection" bleeding time after both drugs administration. In conclusion, captopril and losartan exerted an antithrombotic effect in venous thrombosis model in rats. The precise mechanism of this action should be established.
Pol J Pharmacol
PMID:Effects of drugs affecting the renin-angiotensin system on venous thrombosis in normotensive rats. 911 34

The aim of the study was to investigate the potential antithrombotic action of enalapril in comparison with captopril after their acute and chronic administration in an experimental model of venous thrombosis in rats. Chronic treatment with captopril but not enalapril significantly reduced the incidence of venous thrombosis (67% vs 11%; p < 0.05). Both drugs markedly reduced the weight of thrombus. At the same time the platelet aggregation was reduced in rats acutely treated with both captopril and enalapril to 50 +/- 13% and 53 +/- 18%, respectively. The mean blood pressure dropped only after acute ACE-Is administration. No changes were observed in "transection" bleeding time. In conclusion, captopril and enalapril were able to inhibit the growth of thrombus in rats. Their antithrombotic effect seems to be independent from hypotensive action and influence on platelet aggregation.
Pol J Pharmacol
PMID:Antithrombotic effect of enalapril, an angiotensin-converting enzyme inhibitor, on venous thrombosis in rats. 911 40

Our paper is discussing the presence and intensity of metabolic, humoral and haemodynamic abnormalities in mild middle-aged essential hypertensives (EH) and in hereditary predisposed still normotensive offspring from hypertensive families and their possible association with candidate genes changes. Four groups of subjects were compared (middle-aged normotensive controls (n = 21), corresponding patients with EH (n = 21), normotensive offspring from hypertensive (SH) (n = 56) and normotensive families (SN) (n = 56). Our results demonstrate that middle-aged patients with EH in our country have the same indices of hyperinsulinemia, impared glucose tolerance and insulin-sensitivity as previously described for other populations. They are accompanied by higher plasma concentrations of vasopressor substance like catecholamines, endothelin and lower levels of vasodepressor substances as ANP and kallikrein. The finding of similar, but quantitatively less expressed metabolic and humoral changes in SH but not in SN support the evidence for hereditary background of these abnormalities. The humoral and metabolic abnormalities may participate in BP elevation and in morphological and functional changes of left ventricle seen in SH (higher LV mass index, impaired diastolic filling). We did not prove an association between BP and polymorphism of ACE and angiotensinogen genes, however, our findings of association of DD genotype for ACE and M235 for angiotensinogen with higher insulinemia, plasma catecholamines and plasma renin activity evoke the hypothesis, whether the bearers of these genotypes, exposed for long-time to the higher concentrations of vascoactive substances, are not the subset of hereditary threatened subjects in whom clinically evident EH will manifest during their life.
Pol Arch Med Wewn 1997
PMID:Some metabolic, humoral and genetic aspects of arterial hypertension. 927 55


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