Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.15.1 (ACE)
 18,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum ACE (s-ACE) activity were determined in 112 sarcoid patients and 60 healthy volunteers. The mean s-ACE activity in sarcoid patients were 39.5 +/- 14.1 U. and in healthy volunteers 22.1 +/- 3.6, U. Significant increase of s-ACE was seen in active sarcoidosis 51.2 +/- 13.7 U. Serum ACE activity increased twice or more in comparison with control values imply activity of the process. Serum-ACE determination may be of use as a prognostic factor in sarcoidosis.
Pneumonol Alergol Pol 1991
PMID:[Prognostic value of measuring serum angiotensin I-converting enzyme (ACE) in patients with sarcoidosis]. 166 75

The aim of the study was to investigate whether oxygen causes a further decrease in pulmonary artery pressure after administration of calcium channel blocker-verapamil-or angiotensin converting enzyme inhibitor-captopril-in the secondary pulmonary hypertension. We studied 37 patients with the secondary pulmonary hypertension (mean pulmonary artery systolic pressure = 56.1 mm Hg) due to mitral stenosis. After having completed hemodynamic diagnostic procedures, basal oxygen test was performed and pulmonary artery pressure was recorded at 10 min of oxygen breathing. Then, 10 mg of verapamil was injected into the pulmonary artery of 16 patients and 21 patients received 75 mg of oral captopril. At the peak of vasodilation, 30 min after verapamil and 90 min after captopril administration, pulmonary artery pressure was recorded and oxygen test was repeated. Baseline oxygen test produced a statistically significant decrease in pulmonary artery pressure. Verapamil and captopril also lowered pulmonary artery systolic and diastolic pressures. The second oxygen test did not cause a further decrease in the pulmonary artery pressure; mean pulmonary artery systolic pressure was 52.3 +/- 23.7 mm Hg, pulmonary artery diastolic pressure 22.7 +/- 10.6 mm Hg before and 49.1 +/- 23.8 mm Hg and 23.0 +/- 13.5 mm Hg, respectively after the test in verapamil group, and 47.0 +/- 15.5 mm Hg and 21.7 +/- 8.4 mm Hg before and 46.6 +/- 15.4 mm Hg, respectively in captopril subset. The results may support the thesis that vasodilating effect depends rather on the degree of pulmonary vascular changes than on the vasodilatory mechanism of particular drugs.
Pol Tyg Lek
PMID:[Lack of additional action of oxygen on pulmonary artery pressure at the peak of verapamil or captopril action in pulmonary hypertension secondary to mitral stenosis]. 166 76

In 12 patients with chronic renal failure (CRF) treated with haemodialyses and in 21 healthy controls plasma renin activity (PRA) and the concentrations of aldosterone and atrial natriuretic peptide (ANP) were determined in serum before and after blockade of the angiotensin converting enzyme with captopril. The study was carried out under conditions of the so called bed rest test (BR) and water immersion test (WI). After captopril administration a significant rise of PRA was noted in both groups with a drop of aldosterone level which was significant only in the control group. Captopril administration had no effect on serum ANP level. The results of the study are not suggesting the presence of a close relationship between ANP secretion and the activity of the RAA system in healthy controls and in CRF patients.
Mater Med Pol
PMID:Activity of the renin-angiotensin-aldosterone (RAA) and secretion of the atrial natriuretic peptide (ANP) in patients with chronic renal failure. 184 98

Hypokinesia (diminished muscular activity) elicits several substantial alterations in carbohydrate and lipid metabolism of animals and man. The aim of this study was to examine certain parameters of carbohydrate and lipid metabolism in blood and tissues of 118 rats weighing 180-220 g, during a 90 days' exposure to hypokinesia (HK) and a 90-days' readaptation period (RP), that is, after the termination of HK. All of the rats were divided into experimental and control groups. The experimental group of rats were kept in small individual cages made of plexiglass and the control group of rats was placed under ordinary vivarium conditions. The rats were decapitated on the 90th day of HK and on the 15th, 30th, 60th and 90th days of the RP. Such indices were measured as glycogen (G), total lipid (TL), cholesterol (CH) and triglycerides (TG) in hepatic tissues and skeletal muscles, and glucose-6-phosphate-dehydrogenase (G-6-PDH) activity in the liver and fatty tissues. There were also assayed: blood serum, sugar, total cholesterol, alpha-cholesterol (alpha-CH), beta-cholesterol (beta-CH) lipoproteins, acetone bodies (AB) and free fatty acids (FFA). On the 90th day of HK the content of CH, FFA and AB increased, the value of sugar and TG decreased in blood, the amount of G decreased and the level of CH increased in the liver and skeletal muscles. On the 15th day of RP most of the parameters under study returned to normal. However, G-6-PDH in the liver and adipose tissue were elevated and remained higher till the 60th day of the RP.(ABSTRACT TRUNCATED AT 250 WORDS)
Mater Med Pol
PMID:Carbohydrate and lipid metabolism in rats after hypokinesia. 213 28

In 61 patients with class IV (NYHA) of chronic congestive cardiac failure treated for 2 weeks with digoxin (0.290 +/- 0.108 mg/d) and furosemide (13.0 +/- 4.1 mg/d), for 2 weeks with digoxin, furosemide and isosorbide dinitrate (44.5 +/- 9.8 mg/d) or nifedipine (42.0 +/- 12.2 mg/d), for 4 weeks with digoxin, furosemide, isosorbide or nifedipine and captopril (angiotensin converting enzyme inhibitor) (75.1 +/- 24.4 mg/d), and for the last 2 weeks with digoxin, furosemide, isosorbide or nifedipine without captopril, after each stage the clinical state, exercise tolerance and haemodynamic parameters determined echocardiographically were assessed. Ten weeks of treatment by this method caused regression of pulmonary congestion in 80%, oedema in 63.3% and hepatomegaly in 33.3% of the patients. Moreover, 60.7% of the patients returned to class III, 13.1% to class II, and 26.2% remained in class IV (NYHA). In the group treated with digoxin, furosemide, nifedipine with captopril (n = 30) a significant rise was observed of the value of the ejection fraction and cardiac index in relation to the treatment with digoxin and furosemide and the treatment with digoxin, furosemide, nifedipine (p less than 0.05). No drug improved significantly the tolerance of submaximal exercise. During the treatment with captopril no clinical improvement was achieved in 4 cases, and worsening occurred in 3 cases of severe cardiac failure (7 of 61 patients, 11.5%). The obtained results showed that vasodilating drugs are safe in congestive cardiac failure and in many cases of severe failure captopril contributed to rapid clinical and haemodynamic improvement.
Pol Arch Med Wewn 1990 Aug
PMID:[Results of treatment for severe congestive heart failure with digoxin, furosemide and vasodilating agents]. 227 87

The authors examined in vitro the influence of gonadotrophins, cAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolon and testosterone in the interstitial gland of the rat. Sections of the nucleus were incubated with LH (100 ng/ml), hCG (1.0 j.m./ml), dbcAMP (1 mM), 22-R-OH-cholesterol (30 microM) and cofactors (NAD + NADP + G-6-P + G-6-PDH). It was found that an increase in concentrations of hCG above physiological values was not accompanied by an increase in secreting steroid hormones. LH, hCG and dbcAMP increased the synthesis of pregnenolon twice, and testosterone--three times. 22-R-OH-cholesterol as a substrate increased the synthesis three and four times respectively, and added cofactors five times and four and a half times respectively. Joining 22-R-OH-cholesterol or a cofactor with LH does not intensify a stimulating effect.
Ginekol Pol 1989 May
PMID:[The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. II. Effects of LH, hCG, dbcAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolone and testosterone in the interstitial gland of rats]. 256 59

Two groups of rats (a control group and the group examined) were administered intraperitoneally supraphysiological doses of hCG in order to induce a "down regulation" effect on the level of receptors LH and to achieve the desensibilization of Leydig cells. The authors tried to find out at which stage of sequence of changes from receptor stimulation to hormone production there appears a state of cellular resistance to further stimulation. Sections of the nucleus were incubated with various substances influencing steridogenesis (LH, hCG, dbcAMP, 22-R-OH-cholesterol, NAD + NADP + G-6-P + G-6-PDH). An index of the influence of the above substances on the synthesis of androgens were amounts of pregnenolon as the first and testosterone as the final stage of hormonal changes marked radioimmunologically in nucleus homogenates and incubating media. It was shown that the resistance of Leydig cells to further stimulation in the group of animals that were given high doses of hCG is the result of enzymatic blocks in testosterone synthesis. The first block is "late" block of 17 alpha-hydroxylase and 17-20 desmolase, disturbing transforming of 21-carbon steriods into 19-carbon androgens. When the dose of hCG increases, there appears the second block, the so called "early" block, disturbing mitochondrial synthesis of pregnenolon. It was found that exogenic cofactors are in a position, at least partially, to restore the activity of blocked enzymes.(ABSTRACT TRUNCATED AT 250 WORDS)
Ginekol Pol 1989 May
PMID:[The role of gonadotropins, cyclic AMP, 22-R-OH-cholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. III. Mechanisms responsible for "desensitization" of the Leydig cells of rats caused by high doses of hCG]. 256 60

The authors evaluated the influence of NAD, NADP, G-6-P and G-6-PDH on the synthesis of steroid hormones in the interstitial gland of the rat. The animals were killed by decapitation, and sections of the nucleus weighing altogether 20 mg were incubated with NAD (0.4 mM), NADP (0.4 mM), G-6-P (3.5 mM) and G-6-PDH (2 j.m./ml) for 4 hours in CO2 incubator. Then the tissue was homogenized, removed by centrifugation and then from the homogenous supernatant the authors extracted steroids which were in the incubating medium and in the tissue. Steroid hormones examined were marked radioimmunologically, they were: pregnenolon as the first and testosterone as the second stage of synthesis of nucleus androgens. The search carried out shows that the strongest stimulator in biosynthesis of pregnenolon was NADP together with the reducing system (G-6-P and G-6-PDH). On the other hand, in case of testosterone the highest effectiveness was achieved by simultaneous use of the cofactors examined. Applying cofactors separately the authors were able to find that both NAD and NADP together with the reducing system were responsible for testosterone synthesis and their simultaneous applying in the incubating medium leads to a synergistic effect.
Ginekol Pol 1989 May
PMID:[The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. I. Effect of cofactors on the synthesis of steroid hormones in the interstitial gland of rats]. 263 80

The purpose of the study was to compare the effect of treatment with an angiotensin converting enzyme inhibitor (Lisinopril, MSD) or calcium blocker (Nifedipine retard, MSD) treatment during three months on blood pressure (measured with sphygmomanometric method and ambulatory blood pressure monitoring--ABPM) and urinary albumin excretion in essential hypertension class I acc. to WHO. Fifteen untreated patients aged 38 +/- 5 years with essential hypertension participated in the study and received diet with normal sodium content. Urinary albumin excretion was measured by RIA method in two 24 hour urine collections and mean value was calculated. ABPM was measured with Spacelabs monitor. After first examination 8 patients were randomly selected for the treatment with lisinopril and 7 patients to the treatment with nifedipine. The doses of both drugs were gradually adjusted to reach diastolic blood pressure below 90 mmHg. After 3 months of treatment urinary albumin excretion and blood pressure was found in both after treatment in patients treated with lisinopril but not in those receiving nifedipine. In patients treated with lisinopril a correlation between the decrease in systolic and diastolic blood pressure (measured by ABPM) and decrease of urinary albumin excretion was demonstrated. It was concluded that the normalization of blood pressure induced by lisinopril treatment in patients with uncomplicated essential hypertension and normoalbuminuria is accompanied with significant diminution of urinary albumin excretion which suggests preventive action of the drug in the development of microalbuminuria. Diminution of urinary albumin excretion caused by lisinopril is probably due to both the decrease of blood pressure and the specific renal action of the drug.
Pol Arch Med Wewn 1995 Feb
PMID:[Comparison of treatment effects with an angiotensin converting enzyme inhibitor--lisinopril and a calcium blocker--nifedipine retard on urinary albumin excretion in patients with non-complicated essential hypertension]. 747 31

The aim of the work was evaluation of activity of angiotensin converting enzyme (ACE) in non-insulin dependent diabetes mellitus depending on evidence of hypertonia, duration of diabetes and possibility of fat metabolism disturbances. 20 patients were studied (16 women and 4 men, average age 57.5 years). Average time of duration of diabetes was approximately 9 years (from 1 year to 25 years). The control group included 68 people (34 women and 34 men) in age of 19 to 67 years. Convertase activity was determined by Friedland and Silverstein's spectrofluorometric assay. Average ACE activity values in diabetic patient (44.45 +/- 13.14 mmol/ml/min) were close up to control group values and were not significantly different. Similar significant difference was not ascertain between average ACE activity values in patients with more than and less than 10 years of diabetes, in patients with hypercholesterolemia over and less 300 mg%, in patients with and without hypertonia and in patients with and without LDL hypercholesterolemia over and less 200 mg%. Positive correlation was observed between ACE activity values and triglyceride levels in patients with less than 10 years of diabetes (r = 0.88, p < 0.01) and in patients with hypercholesterolemia over 300 mg% (r = 0.75, p < 0.01). In this last group, in addition, the positive correlation was present between ACE activity values and total cholesterol levels (r = 0.86, p < 0.001). Correlation between ACE activity and total cholesterol level was ascertained in patients with LDL hypercholesterolemia over 200 mg% too (r = 0.81, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Pol Arch Med Wewn 1995 Apr
PMID:[Activity of converting enzyme angiotensin I to angiotensin II (ACE) in patients with diabetes type II]. 747 54


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