Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.15.1 (
ACE
)
18,300
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Effects of condensed tannins isolated from Rhei Rhizoma on the activities of
angiotensin converting enzyme
(
ACE
) and various proteases were examined in vitro. Among the various condensed tannins tested, procyanidin
B-5
3,3'-di-O-gallate and procyanidin C-1 3,3',3"-tri-O-gallate strongly inhibited the activity of
ACE
. The concentration of procyanidin
B-5
3,3'-di-O-gallate required for 50% inhibition of
ACE
was 1.3 X 10(-6) M. The inhibition of
ACE
by condensed tannins was reversible and non-competitive, according to dialysis and to Dixon plots. However, over one hundred times the concentration was required to inhibit activities of other proteases such as trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A and urinary kallikrein. These results suggest that the inhibitory effects of condensed tannins on the activities of
ACE
are specific.
...
PMID:Inhibitory effects of condensed tannins on angiotensin converting enzyme. 303 68
