Gene/Protein Disease Symptom Drug Enzyme Compound
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 18,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of the antihypertensive drug captopril on salivary secretion rate and composition was evaluated in 24 healthy adults (18-46 yr) according to a double-blind, cross-over design. Unstimulated and paraffin-chewing stimulated whole saliva and 3% citric acid stimulated parotid and submandibular-sublingual (SM-SL) secretion were collected at 10.30 a.m. (about 2h after intake of breakfast) on day 0 (baseline values), day 1 (experimental acute values) and day 7 (experimental chronic values) in each treatment period. In 8 of the subjects, also morning samples were collected at 7.30 a.m., with the test subjects in a fasting condition. Whole saliva was assessed for flow rate and for concentrations of sodium, potassium, chloride, calcium and phosphate. In addition, parotid and SM-SL secretion were assessed for concentrations of total protein, hexosamine, sialic acid, lactoferrin and salivary IgA and for activities of amylase, lysozyme and salivary peroxidase. During treatment with the angiotensin converting enzyme inhibitor captopril, the secretion rates tended to increase for unstimulated and paraffin-chewing stimulated whole saliva and for parotid secretion. For salivary composition, no alterations were observed in any of the collected secretions.
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PMID:Effects of the antihypertensive drug captopril on human salivary secretion rate and composition. 874 69

The heme peroxidase-catalyzed iodination of human angiotensins I and II is described. It is observed that lactoperoxidase (LPO) can effectively and selectively iodinate the tyrosyl residues in angiotensin peptides. The thiourea/thiouracil-based peroxidase inhibitors effectively inhibit the iodination reactions, indicating that iodination is an enzymatic reaction and the mechanism of iodination is similar to that of peroxidase-catalyzed iodination of thyroglobulin. This study also shows that the monoiodo Ang I is a better substrate for the angiotensin converting enzyme than the native peptide.
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PMID:Heme peroxidase-catalyzed iodination of human angiotensins and the effect of iodination on angiotensin converting enzyme activity. 1859 23

To perform unconstrained face recognition robust to variations in illumination, pose and expression, this paper presents a new scheme to extract "Multi-Directional Multi-Level Dual-Cross Patterns" (MDML-DCPs) from face images. Specifically, the MDML-DCPs scheme exploits the first derivative of Gaussian operator to reduce the impact of differences in illumination and then computes the DCP feature at both the holistic and component levels. DCP is a novel face image descriptor inspired by the unique textural structure of human faces. It is computationally efficient and only doubles the cost of computing local binary patterns, yet is extremely robust to pose and expression variations. MDML-DCPs comprehensively yet efficiently encodes the invariant characteristics of a face image from multiple levels into patterns that are highly discriminative of inter-personal differences but robust to intra-personal variations. Experimental results on the FERET, CAS-PERL-R1, FRGC 2.0, and LFW databases indicate that DCP outperforms the state-of-the-art local descriptors (e.g., LBP, LTP, LPQ, POEM, tLBP, and LGXP) for both face identification and face verification tasks. More impressively, the best performance is achieved on the challenging LFW and FRGC 2.0 databases by deploying MDML-DCPs in a simple recognition scheme.
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PMID:Multi-Directional Multi-Level Dual-Cross Patterns for Robust Face Recognition. 2704 95