Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.15.1 (ACE)
 18,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The rate of pseudarthrosis in 726 conservatively treated fractures of the clavicula was 0.69%. The danger of hyperporoses lies in neurovascular compression. Errors in treatment pertain to wrong operative indications and inadequate osteosyntheses. Surgery should be performed only in 2nd and 3rd degree open fractures and/or concomitant neurovascular lesions (2.06%), in distal fracture dislocations with instability of the AC-joint (1.6%) and in cases of painful pseudarthrosis (n = 46). The implant of choice is the 3.5 DCP. Six cortical contacts must be achieved in each fragment.
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PMID:[Errors and dangers in the treatment of fractures and pseudarthroses of the clavicle]. 650 42

This paper provides a method for directly determining vanadium in workplace air by direct current plasma atomic emission spectrometry (DCP-AES). Wavelength selection, instrument operating parameters, and sample preparation methods were studied. It was found that the most suitable wavelength for the analytical line is 437.924 nm (DL 0.006 mg/L) but also the line 309.311 nm (DL 0.003 mg/L) can be used. The results obtained by DCP-AES were compared with those obtained by both flame (FAAS) and electrothermal atomization (ETA-AAS) atomic absorption spectrometry.
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PMID:Determination of vanadium in workplace air by DCP emission spectrometry. 662 49

The appearance of chief cells was studied in normal dogs and in dogs after anterior and bilateral highly selective vagotomy. The normal chief cell is columnar in shape, with a well-defined cell membrane, basal nucleus and basophilic cytoplasm. Many cells show what has been called the 'disappearing chief cell phenomenon'--DCP. The features of the DCP are striking. There is fragmentation of the cell membrane, loss of cytoplasm, changes in the appearance of the nucleus and actual disappearance of some cells. The parietal cells remain normal. The DCP is seen in normal mucosa and should not be regarded as evidence of chronic gastritis. From this preliminary study it is suggested that the procedure of highly selective vagotomy may have a specific effect on pepsin secreting cells, increasing the amount of the DCP.
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PMID:The disappearing chief cell phenomenon (DCP): a preliminary report. 664 Feb 49

Chlorinated bisphenol antibacterial and antifungal agents are potent inhibitors of torula yeast glucose-6-phosphate dehydrogenase (G6PD). Several compounds were tested, including hexachlorophene [HCP; 2,2'-methylenebis(3,4,6-trichlorophenol)]; 2,2'-oxybis(tetrachlorophenol); 2',4-dihydroxy-2,3,3',5,5',6-hexachlorodiphenylmethane; 2,2'-methylenebis(3,4-dichlorophenol) (3,4-TCP); bithionol [2,2'-thiobis(4,6-dichlorophenol)]; 2,2'-methylenebis(3,5-dichlorophenol); 2,2'-dihydroxy-3,3',5,6,6'-pentachlorodiphenylmethane; 2,2'-methylenebis(4-chlorophenol) (DCP); 2,2'-methylenebis(4,6-dichlorophenol); and the related uncoupler 2,4-dinitrophenol. The relative inhibitory activity of the chlorinated bisphenols tended to increase with degree of chlorination of the aromatic rings. the concentrations of the bisphenols that caused 50% inhibition ranged from 2.5 micrometers for 2,2'-oxybis(tetrachlorophenol) to 40 micrometers for 2,2'-methylenebis(4,6-dichlorophenol) under comparable assay conditions. More detailed kinetic analysis showed that, as with HCP, the inhibition of G6PD by 3,4-TCP and DCP followed noncompetitive kinetics. Calculations from the kinetic data gave apparent inhibition constant (Ki) values for 3,4-TCP of 267 micrometers with G6P and 308 micrometers with NADP, and for DCP of 697 micrometers with both G6P and NADP.
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PMID:Effects of chlorinated bisphenols on torula yeast glucose-6-phosphate dehydrogenase. 680 84

Mechanical properties of cortical and cancellous interposition grafts in rabbit tibiofibular bones fixed with 6-hole DCP/ASIF plates were tested with torsional loading after intervals of 3 to 52 weeks postoperatively. In the cortical grafts maximum torque moment at fracture, energy absorption capacity and rigidity increased from 3 to 12 weeks, while the cancellous grafts were more plastic with lower rigidity, higher angular deformation and higher energy absorption. From 12 to 52 weeks maximum torque moment at fracture, energy absorption, rigidity and angular deformation decreased in grafts of both types, the respective means at 36 weeks being 39, 34, 57 and 82 per cent of the cortical grafts, and 26, 17, 42 and 58 per cent of the control values for the cancellous grafts. The differences between the torsional properties of the two graft types decreased with time.
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PMID:Torsional strength of cortical and cancellous bone grafts after rigid plate fixation. 702 56

Embryos of fathead minnows were more resistant to phenol, 2,4-dimethylphenol (2,4-DMP), 2,4-dichlorophenol (2,4-DCP), and pentachlorophenol (PCP) than were larval or juvenile life stages. Growth of 28-day-old fish was the most sensitive indicator of stress during exposures to phenol, 2,4-DMP, and PCP, whereas survival was the most sensitive indicator of toxic effects from 2,4-DCP exposure. Based on these effects, the estimated maximum acceptable toxicant concentration for fathead minnows in Lake Superior water lies between 1,830 and 3,570 micrograms/L for phenol; 1,970 and 3,110 micrograms/L for 2,4-DMP; 290 and 460 micrograms/L for 2,4-DCP; and 44.9 and 73.0 micrograms/L for PCP.
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PMID:Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas). 707 20

1. Liposomes (multilamellar vesicles, MLV) were prepared which entrapped triiodothyronine (T3). The MLV were composed of dimyristoylphosphatidylcholine, cholesterol and dicetylphosphate as DMPC alone, DMPC:Chol (7.2 molar ratio) and DMPC:Chol:DCP (7:2:1 molar ratio). 2. The optimal T3 entrapment was within MLV composed of DMPC: Chol:DCP. The entrapped concentrations of T3 was 63.1%. 3. The MLV composed of DMPC:Chol:DCP did not leak T3 from the MLV into buffered saline but did leak T3 into serum (42.5% after 4 h). 4. The MLV composed of DMPC:Chol:DCP exhibited a distribution of T3 between membrane associated and membrane entrapped of 42.58%.
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PMID:Liposome carrier vehicle for triiodothryonine. 709 28

The metabolism and distribution of 2,4-dichlorophenol (2,4-DCP) were studied in the rat after intravenous administration of 10 mg/kg. 2,4-DCP was determined by gas chromatography with an electron-capture detector. The highest concentration of 2,4-DCP was found in kidney, followed by liver, fat, and brain. 2,4-DCP is metabolized to glucuronide and other conjugates. The parent compound and its conjugates were rapidly eliminated from the body. The half-lives of 2,4-DCP and its conjugates in plasma, fat, brain, liver, and kidney ranged from 4 to 30 min. The volume of distribution of 2,4-DCP in plasma was 3.7 l/kg. Tissue/plasma ratios indicated that 2,4-DCP has a greater affinity for kidney.
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PMID:Distribution and metabolism of 2,4-dichlorophenol in rats. 712 May 15

The individual roles of hepatic parenchymal cells and non-parenchymal cells in the uptake of intravenously injected liposomes by the liver have not yet been clearly determined. Experimentally, it is suggested that a portacaval shunt reduces the phagocytic capacity of the liver RES. In our experiments a portacaval shunt does not influence the hepatic uptake of 14C-Chol-PC-DCP-liposomes and the liposome entrapped 3H-Methotrexate in rats. In normal rats and in rats with a portacaval shunt, most of the 14C- and 3H-radioactivity is found in the liver and the ratio between the amounts of free and liposome entrapped radioactivity 3 to 15 hours after i.v. injection is approximately 1:10. Therefore, it is concluded that the liver RES does not play an integral role in the enrichment of liposomes in the liver.
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PMID:Influence of a portacaval shunt on the distribution of 14C-chol-PC-DCP-liposomes and liposome entrapped 3H-methotrexate in the organs of rats. 721 53

Experimental osteotomies were made in 35 rabbit tibiofibular bones and fixed with rigid stainless steel osteosynthesis plates (DCP/ASIF). The radiographic and histopathologic appearances in the healing osteotomies and adjacent bone were analysed at intervals from 3 up to 24 weeks postoperatively. Radiologically the osteotomy had closed at 9 weeks and microscopically this could be confirmed as longitudinal orientation of the cutter heads across the osteotomy gap with longitudinal orientation of the bone structure. The healing of the osteotomy was accompanied by gross structural changes in the adjacent cortical bone with loss of intracortical and subendosteal osteons, cementing lines and intermediate tissue between the osteons. This was characterized by decreasing attenuation of the cortical bone after healing of the osteotomy and should clinically be regarded as an indication for removal of the implant.
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PMID:Radiographic evaluation of fracture healing after rigid plate fixation: experiments in the rabbit. 734 23


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