Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.15.1 (ACE)
 18,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypothetically, certain ischemic and reperfusion arrhythmias may result from the activity of the calcium-dependent transient inward current. The effects of the angiotensin converting enzyme inhibitor, perindoprilat, on the transient inward current of guinea pig ventricular myocytes were studied. The transient inward current was evoked by superfusing the cell with a modified Tyrode's solution (5.4 mM CaCl2 and 0.54 mM KCl). Repetitive voltage clamp steps from a holding potential of -55 to +20 mV (1,000 ms, 0.1 Hz) were applied while dialyzing the cell internally. When administered simultaneously with the change over to the low K+ high Ca2+ solution, perindoprilat (1 microM) decreased the transient inward current from -9.55 +/- 0.31 to -3.24 +/- 0.24 microA/cm2 (p less than 0.05). A similar decrease was observed when perindoprilat was administered after first inducing the transient inward current. Perindoprilat also protected from the effects of norepinephrine (0.01 and 0.1 microM), which increased the amplitude of the transient inward current from -9.76 +/- 0.17 and -9.99 +/- 0.32 microA/cm2 at the end of the 15-min control period to -11.13 +/- 0.67 and -12.67 +/- 0.49 microA/cm2, respectively (p less than 0.05). The effects of perindoprilat were independent of angiotensin II, which in this preparation decreased the transient inward current. Based on our results, we conclude that perindoprilat decreases the transient inward current and prevents the action of norepinephrine on the transient inward current. The direct effect of the angiotensin converting enzyme inhibitor observed on the transient inward current might explain why angiotensin converting enzyme inhibitors reduce calcium-dependent ouabain-induced or reperfusion arrhythmias.
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PMID:Effects of the ACE inhibitor, perindoprilat, and of angiotensin II on the transient inward current of guinea pig ventricular myocytes. 137 83

Cyclic analogs of bradykinin (CBK) and kallidin (CK) have a weak myotropic activity and a marked and prolonged hypotensive effect unlike linear bradykinin (BK) and kallidin (K) which produce a short-term hypotension and considerable contraction of rat uterus smooth muscles. Myotropic effects of BK and CK were significantly inhibited by phentolamine, methysergide, papaverine and verapamil. Atropine, diphenhydramine and propranolol have no influence on the kinin-induced myotropic responses. The prolonged decrease in blood pressure induced by CBK and CK is observed in un- and anesthetized normotensive, spontaneously hypertensive rats and rats with renovascular hypertension and is absent from anesthetized cats and guinea-pigs. This indicates the species specificity of cyclokinins. Indomethacin, diphenhydramine and methysergide failed to influence the BK- and CK-induced hypotensive effects on anesthetized rats. CaCl2 did not influence the magnitude of the hypotensive effect of BK and CK, however, it significantly shortened the duration of the CK-induced hypotensive effect. In vitro CBK and CK inhibited activity of kininase II in a similar manner (at a concentration range of 10(-5) M) but to a less extent than BK (10(-7)-10(-6) M). It is suggested that the hypotensive effect of CK is mediated at least partly via Ca2+-dependent systems and inhibition of kininase II.
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PMID:[Mechanism of action of cyclokinins]. 631 9

Organosilicate nanocomposite hexagonal mesostructure (NHMS) was synthesized from dodecylamine and tetraethyl orthosilicate (TEOS). The nanocomposite (NMCM) of numbers 41, 48, and 50 were synthesized from cetyltrimethylammonium bromide (CTABr) and (TEOS). The rates, affinity, and stability of these synthetic nanocomposite materials to remove and retain chlorinated phenols from aqueous solution were investigated; all materials have the ability for sorption and retention of 2,4-dichlophenol (2,4-DCP). Batch absorption kinetics indicates that NHMS, NMCM-41, NMCM-48, and NMCM-50 are 1st order reactions, with rate constants of 0.412, 0.296, 0.112, and 0.0161 hr(-1), respectively. Average percent 2,4-DCP removal for NHMS, NMCM-41, NMCM-48, and NMCM-50 was 92, 98, 90, and 52%, respectively. Isothermic measurements fit Freundlich and Langmuir models. NHMS and NMCM-41 best fit Langmuir model. Stability of the adsorbents in 0.10 M CaCl2 for 56 days was in the order: NMCM-41 > NHMS > NMCM-50 > NMCM-48.
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PMID:Organo-silicate nanocomposites for the removal of chlorinated phenols from aqueous media: kinetics and environmental stability. 1553 9