Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.15.1 (
ACE
)
18,300
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Angiotensin-converting enzyme (
kininase II
, E. C., 3.4.15.1) activity was present in lumbar cerebrospinal fluid of paranoid schizophrenic patients and psychiatrically healthy controls. Both schizophrenics under neuroleptic treatment and drug-free patients had low cerebrospinal enzyme activity when compared with controls. No correlation existed with the scores of the Brief Psychiatric Rating Scale. A negative correlation of enzyme activity with cerebrospinal levels of both dopamine and noradrenaline was detected. Our findings suggest the possibility of a central alteration of the metabolism of neuropeptides in
paranoid schizophrenia
.
...
PMID:Low angiotensin-converting enzyme activity (kininase II) in cerebrospinal fluid of schizophrenics. 614 52
