Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.11.18 (MAP)
 7,412 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MAP 7114
p38 956
MAP kinase 708
ERK 671
ERK1 603
JNK 570
Sep 495
Mol 448
MAPK 410
MEK 303
cytokine 291
methionine aminopeptidase 271
mitogen-activated protein 218
ERK2 190
insulin 188
p42 157
TNF 155
c-Jun 153
phosphatase 153
tyrosine kinase 150
ATP 145
threonine 141
IL-6 140
p38 MAP kinase 130
extracellular signal-regulated kinase 129
caspase-3 119
p44 117
MEK1 117
PKC 114
AP-1 112
angiotensin II 110
LPS 107
p53 107
lipopolysaccharide 104
renin 104
PI3K 97
AKT 94
SBP 92
DBP 91
CO2 90
TNF-alpha 86
SAP 85
inducible nitric oxide synthase 84
collagen 84
Bcl-2 83
IL-8 81
microtubule-associated protein 79
nitric oxide synthase 76
c-fos 72
Raf-1 70
BRAF 67
EGF 66
tumor necrosis factor 65
PI3 65
mTOR 64
JNK1 63
IL-10 61
p21 60
ROS 60
Ang II 59
chemokine 59
Rho 59
phosphatidylinositol 3-kinase 58
DAP 57
epidermal growth factor 56
hemoglobin 55
ICP 54
AMP 54
Pseudomonas 53
polypeptide 53
TLR4 53
COX-2 52
GTP 50
MEKK 49
CREB 49
PI3-kinase 49
calmodulin 48
epidermal growth factor receptor 48
PKA 45
fibronectin 45
STAT 45
vasopressin 44
LC3 44
ras 44
IL-1 43
CD4 43
Met 43
SDS 43
receptor tyrosine kinase 42
IL-4 42
cyclin 41
Cytokine 41
superoxide dismutase 40
IFN 40
PDGF 39
p65 39
albumin 38
MAP-2 38
cyclin D1 38
vascular endothelial growth factor 38
MAP2 37
EGFR 36
IL-2 36
ATPase 36
TPR 36
endothelin-1 36
MKP-1 36
axonal 35
thrombin 35
ANG 35
GSH 34
VEGF 34
catalase 34
AT1 34
proteasome 33
P38 33
myelin basic protein 33
gut 33
interleukin-6 32
insulin receptor 32
TGF-beta 32
GFR 32
IRS-1 32
cyclooxygenase-2 32
PKB 32
ubiquitin 31
EGF receptor 31
Fas 31
phosphoinositide 3-kinase 31
extracellular signal-regulated kinase 1 31
endoplasmic reticulum 31
RAF 30
TLR2 30
RhoA 30
interferon 30
STAT3 29
PLC 29
membrane-bound 29
bradykinin 28
C-reactive protein 28
serine/threonine kinase 28
PARP 28
JNK2 28
THP 28
MCP-1 28
MKK4 28
p38MAPK 28
protein kinase B 28
FGF 28
calcineurin 27
insulin-like growth factor 27
haptoglobin 27
glycoprotein 27
glial fibrillary acidic protein 27
KRAS 27
ANOVA 27
nerve growth factor 27
arginine vasopressin 27
eNOS 27
NMR 26
more...
Disease
cancer 517
hypertension 324
tumor 309
stroke 163
diabetes 105
breast cancer 105
ischemia 104
Alzheimer's disease 84
atherosclerosis 70
carcinoma 67
sepsis 66
melanoma 66
sepsis 65
Mycobacterium 65
depression 62
heart failure 59
obesity 55
neuroblastoma 55
carcinogenesis 54
ICP 54
NAME 53
cold 51
pertussis 50
tumor growth 49
tumorigenesis 48
colorectal cancer 47
ATM 47
hepatocellular carcinoma 47
SDS 43
essential hypertension 42
leukemia 41
SEM 41
MCF 40
HIV 40
adenocarcinoma 36
cardiovascular disease 35
renal disease 35
GSH 34
metastases 34
prostate cancer 33
glioma 33
tumor progression 32
preeclampsia 28
myocardial infarction 27
Blocking 26
lung cancer 26
Johne's disease 25
rheumatoid arthritis 24
proteinuria 24
hyperglycemia 23
arthritis 22
erectile dysfunction 22
infectious diseases 22
asthma 22
type 2 diabetes 22
colon cancer 21
myocardial ischemia 21
ovarian cancer 21
immunodeficiency 21
lymphoma 20
tuberculosis 20
renal failure 19
polyposis 19
schizophrenia 18
AIDS 18
gastric cancer 18
dementia 18
Crohn's disease 18
cerebral ischemia 18
squamous cell carcinoma 17
ventricular hypertrophy 17
Parkinson's disease 17
MAC 17
coronary artery disease 17
acute myeloid leukemia 15
colitis 15
renal cell carcinoma 15
multiple myeloma 15
pulmonary hypertension 15
chronic obstructive pulmonary disease 15
pancreatic cancer 15
multiple sclerosis 14
MIP 14
APC 14
lung carcinoma 14
systemic lupus erythematosus 14
anemia 14
metabolic syndrome 14
psychosis 14
Evans 14
inflammatory bowel disease 13
virus infection 13
bacterial infection 13
HGF 13
skin cancer 13
pheochromocytoma 13
non-small cell lung cancer 13
endotoxic shock 13
lung disease 13
chronic renal failure 13
acute pancreatitis 12
mole 12
cirrhosis 12
PCP 11
coma 11
influenza 11
cardiomyopathy 11
heart disease 11
dehydration 11
glioblastoma 11
Schistosoma mansoni 11
metastatic melanoma 10
malaria 10
Leukemia 10
familial adenomatous polyposis 10
sarcoma 10
diabetic nephropathy 10
mole 10
leishmaniasis 10
portal hypertension 10
epithelial ovarian cancer 10
congestive heart failure 10
type 1 diabetes 10
Yersinia 10
astrocytoma 10
ventricular fibrillation 9
subarachnoid hemorrhage 9
epilepsy 9
infertility 9
glomerulosclerosis 9
chronic myeloid leukemia 9
endometrial cancer 9
diabetic retinopathy 9
West 9
LAP 9
plaque 9
aggressiveness 9
osteosarcoma 9
acute myocardial infarction 9
coronary heart disease 9
SAR 9
pneumonia 9
osteoarthritis 9
malnutrition 8
acute promyelocytic leukemia 8
Melanoma 8
dyslipidemia 8
schistosomiasis 8
Infection 8
vascular disease 8
Best 8
retinoblastoma 8
tumor angiogenesis 8
anaphylaxis 8
Epstein 8
hyperinsulinemia 8
B-cell lymphoma 8
autoimmune disease 8
glioblastoma multiforme 8
CIE 8
more...
Symptom
anesthesia 178
pain 55
analgesia 30
hypercapnia 27
hypothermia 18
starvation 16
collapse 15
diarrhea 14
seizures 13
fatigue 11
overweight 9
exhaustion 8
cough 7
respiratory distress 6
dyspnea 6
hypocapnia 6
vomiting 6
chills 5
nausea 5
hyperoxia 5
exertional dyspnea 5
acidity 4
syncope 4
flushing 4
sinus pressure 4
acute stress 4
headache 4
functional recovery 4
skin damage 3
discomfort 3
anorexia 3
presyncope 3
spasm 3
thinning 3
discomfort 3
paresis 3
pelvic pain 3
nausea and vomiting 3
tremor 3
Sedation 3
cachexia 2
sleepiness 2
weakness 2
constipation 2
memory loss 2
polyuria 2
wheezing 2
neck pain 2
ataxia 2
colic 2
tachypnea 2
angina 2
HSA 2
lethargy 1
Postoperative nausea and vomiting 1
vertigo 1
general problem 1
DNA marker 1
ENT 1
dystonia 1
skin irritation 1
regurgitation 1
Diaphragmatic weakness 1
phosphatemia 1
paresthesia 1
bradypnea 1
despair 1
muscle cramps 1
bradykinesia 1
bitter taste 1
Neuropathic pain 1
tinnitus 1
hypotonia 1
acute pain 1
muscle rigidity 1
Organ failure 1
sneezing 1
shortness of breath 1
scaly skin 1
Tenderness 1
impaired body balance 1
apathy 1
asthenia 1
Halo 1
numbness 1
shoulder pain 1
abdominal pain 1
snoring 1
loss of balance 1
leg cramps 1
oliguria 1
Drug
MAP 7114
Cardiovasc 72
ROS 60
lysine 41
IL-2 36
CSF 31
Monit 31
Angiotensin II 20
Ringer's solution 18
nitroglycerin 17
IFN-gamma 17
vitamin E 16
Ethanol 15
caffeine 15
Dermatol 15
Nephron 13
Captopril 12
PCP 11
Taxol 11
Leaf 11
NADH 11
ascorbate 10
ETS 9
ETA 9
CTX 8
Propofol 8
Nitric Oxide 7
uPA 7
Asn 7
EE2 6
Imatinib 6
TAK 6
ICI 6
IFN-beta 6
Dial 6
DMAP 6
Indomethacin 6
Albumin 5
Biopolymers 5
PTH 5
ROC 5
Asthma 5
Clonidine 5
Adenosine triphosphate 4
PTC 4
Estrogens 4
Ouabain 4
Fentanyl 4
citric acid 4
Glutathione 4
MOF 4
Gel 4
Adriamycin 4
TAT 4
Sodium nitroprusside 4
Sorafenib 4
Capsicum 4
CoCl2 3
Hydroxyethylstarch 3
TTC 3
ABC 3
HCH 3
G418 3
Arimidex 3
DHT 3
Gleevec 3
Apomorphine 3
Infliximab 3
Heme 3
Retinoic acid 3
Diurnal 3
DHT 3
Histamine 3
Phosphoramidon 3
IL-1ra 3
Enalaprilat 3
Growth hormone 3
Phentolamine 3
Forskolin 3
Lactic Acid 3
IL-11 3
Infliximab 3
-deoxyadenosine 3
Silica 3
CoCl2 3
Enalaprilat 3
Kenyan 3
BH4 3
Atropine 3
lactose 3
Gefitinib 2
NAG 2
OMP 2
Posture 2
DEX 2
Xaliproden 2
Portal 2
Troglitazone 2
CDP 2
ZnO 2
Ginger 2
L-tyrosine 2
Herceptin 2
CaCl2 2
G-CSF 2
CEC 2
Growth hormone 2
Gelatin 2
CaCl2 2
Papain 2
Ciglitazone 2
Paraffin 2
Nephron 2
CaCl2 2
Felodipine 2
Lovastatin 2
p75 2
Citric acid 2
FAD 2
Pronase 2
Terlipressin 2
Gastro 2
MRC 2
THF 2
ADR 2
Simvastatin 2
Bifidobacterium 2
Olomoucine 2
AMC 2
Erlotinib 2
CAM 2
niacin 2
ampicillin 2
CCL 2
TAC 2
Terlipressin 2
GRF 2
Depo-Provera 2
Abatacept 2
ADM 2
Lercanidipine 1
Lacidipine 1
Theophylline 1
DM1 1
Irinotecan 1
Perindopril 1
CTX 1
CTX 1
IPD 1
Fulvestrant 1
Urokinase 1
Norgestomet 1
ACT 1
GEO 1
CIA 1
CTC 1
EPA 1
RFP 1
Docetaxel 1
Pramipexole 1
more...
Enzyme
MAP 7412
mitogen-activated protein kinase 1909
ERK 799
MEK 435
protein kinase 388
protein kinase C 256
focal adhesion kinase 130
renin 104
caspase-3 86
MEKK1 67
calcineurin 62
phosphatidylinositol 3-kinase 58
superoxide dismutase 52
luciferase 48
cdc2 47
NO synthase 47
catalase 41
phospholipase C 40
NADPH oxidase 40
ATPase 39
proteasome 35
thrombin 33
NADPH oxidase 33
phosphoinositide 3-kinase 31
PARP 31
peroxidase 30
ACE 30
NOS 29
IKK 29
GSK 28
glutathione S-transferase 26
phospholipase A2 25
alkaline phosphatase 24
phosphodiesterase 24
collagenase 23
trypsin 22
CaMKII 22
lactate dehydrogenase 21
AMPK 21
creatine kinase 20
kinesin 19
adenylate cyclase 19
alanine aminotransferase 18
MAT 17
MAT 17
prolidase 17
aspartate aminotransferase 16
peptide deformylase 15
APC 15
reverse transcriptase 15
ACS 14
ornithine decarboxylase 14
MIP 14
caspase-9 13
glutathione peroxidase 13
PRA 13
AMP-activated protein kinase 13
protein phosphatase 2A 11
urokinase-type plasminogen activator 11
RNA polymerase 11
PCP 11
lipoxygenase 11
glyceraldehyde-3-phosphate dehydrogenase 10
phospholipase D 10
PAH 10
tyrosine hydroxylase 9
MMP-3 9
lipase 9
heme oxygenase 9
topoisomerase 9
guanylate cyclase 9
AST 9
AMPK 9
MMP 8
alcohol dehydrogenase 8
CD10 8
topoisomerase 8
PTPase 8
CD13 8
peroxiredoxin 7
caspase-8 7
transcriptase 7
elastase 7
tyrosinase 7
glyceraldehyde-3-phosphate dehydrogenase 7
aminopeptidase P 7
beta-galactosidase 6
plasmin 6
xanthine oxidase 6
caspase-7 6
BIS 6
hexosaminidase 6
monoamine oxidase 6
BAL 6
caspase-7 6
PKG 6
papain 6
myosin light chain kinase 6
caspase-1 6
ADH 5
thioredoxin reductase 5
cathepsin B 5
NQO1 5
adenosine deaminase 5
PDK1 5
adenosine deaminase 5
lysozyme 5
acetylcholinesterase 5
creatinase 5
RNase 5
chymotrypsin 5
glyceraldehyde-3-phosphate dehydrogenase 4
aldehyde dehydrogenase 4
RNase 4
ricin 4
tissue plasminogen activator 4
DCF 4
ribonucleotide reductase 4
CPT 4
CPT 4
CPT 4
ribonucleotide reductase 4
acid phosphatase 4
glyceraldehyde-3-phosphate dehydrogenase 4
glyceraldehyde-3-phosphate dehydrogenase 4
CAD 4
CAD 4
S-adenosylmethionine decarboxylase 4
TAT 4
choline acetyltransferase 4
CAD 4
leucine aminopeptidase 4
thromboplastin 4
phosphatidylinositol 4-kinase 3
alpha-glucosidase 3
CLK1 3
lipoprotein lipase 3
15-hydroxyprostaglandin dehydrogenase 3
glycerol-3-phosphate dehydrogenase 3
dihydrofolate reductase 3
phosphoglycerate kinase 3
arginase 3
soluble epoxide hydrolase 3
gamma-glutamyl transpeptidase 3
SCP 3
glutathione reductase 3
glycerol-3-phosphate dehydrogenase 3
glucose-6-phosphate dehydrogenase 3
m-calpain 3
sphingosine kinase 3
methionyl-tRNA synthetase 3
kallikrein 3
CPN 3
complex I 3
aldehyde dehydrogenase 3
cathepsin L 3
HSD 3
aldose reductase 3
aldehyde dehydrogenase 3
DNA methyltransferase 3
more...
Compound
MAP 7114
Dec 524
oxygen 524
DNA 428
tyrosine 424
calcium 315
sodium 263
Clin 236
water 234
MEK 233
threonine 198
nitric oxide 196
serine 194
acetate 173
glucose 157
TNF 155
ATP 145
methionine 141
arginine 129
CO2 128
cAMP 117
phosphate 112
salt 99
DBP 91
DBP 91
hydrogen 82
nitrogen 74
lysine 67
glutamate 61
Diazepam 60
alanine 60
cysteine 58
DAP 57
DAP 57
AMP 57
potassium 56
noradrenaline 53
leucine 52
GTP 50
proline 50
ethanol 50
creatinine 47
Asp 45
SDS 44
His 44
NH2 42
Ang II 42
Phe 41
Cardiol 40
zinc 40
cobalt 40
Insulin 38
cGMP 38
GSH 37
GSH 37
ammonium 36
aldosterone 35
MDA 34
iron 34
MTT 33
phosphorus 33
H2O2 32
PMA 32
THP 31
glycerol 31
ASA 31
PMA 31
COS 30
Angiotensin II 29
Gly 28
THP 28
manganese 27
sulfate 26
Tyrosine 26
PAP 25
ADP 25
PAP 25
PAP 25
PAP 24
CPP 24
N2O 24
PGE 24
CPP 24
ADP 22
Progesterone 22
ADP 22
urea 22
N-acetylcysteine 21
TPA 21
TPA 21
ATF 20
NMDA 20
NADPH 18
aspartic acid 18
NADPH 18
5-HT 18
retinoic acid 18
GABA 18
GABA 18
H-3 18
PGE2 17
aspartic acid 17
GDP 17
aspartic acid 17
aspartic acid 17
cadmium 17
nitrate 16
vitamin D 16
ammonia 16
prostacyclin 15
ACS 15
caffeine 15
hydroxide 15
ACS 14
iodine 14
ACTH 14
Salt 14
pyrimidine 14
valine 14
Ile 13
FBF 13
copper 13
pyrimidine 13
CAM 12
EDTA 12
PEG 12
EDTA 12
PCP 12
salicylic acid 12
Cer 12
bromide 12
GAP 12
DMSO 12
MCA 11
glutamine 11
acetic acid 11
glutamic acid 11
nickel 11
Dopamine 11
Norepinephrine 11
galactose 11
TOF 11
Neuronal 11
MCA 11
NADH 11
Rapamycin 11
Adrenal 11
PPI 10
CAP 10
sodium chloride 10
Serine 10
PAH 10
Pac 9
Hemoglobin 9
silver 9
aluminum 9
ETA 9
Sodium 9
NAD 9
tryptophan 9
more...