Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.11.18 (MAP)
 7,412 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study we estimated the periodic profiles and variance structure of systolic blood pressure, diastolic blood pressure, heart rate and mean arterial pressure by using an autoregressive model of power spectrum, Maximum Entropy Method (MEM) in 8 patients with primary aldosteronism, during long-term therapy with nicardipine slow release. The four blood pressure variables were measured at 30-min intervals, using a noninvasive device (Spacelabs 90202) in 8 hypertensive patients of whom 6 with idiopathic aldosteronism (IHA) and 2 with dexamethasone-suppressible aldosteronism (DSH), before and after 24 weeks of 80 mg nicardipine daily. Blood pressure data were processed by MEM and spectral profiles were obtained. During nicardipine therapy all patients showed a significant decrease of 24-h ambulatory blood pressure values (p < 0.01). Before therapy, spectrum analysis by MEM indicated the presence of high frequency distribution of peaks for SBP, DBP, MAP and HR. The MEM power spectrum showed an increase in amplitude of sharp peaks of systolic, diastolic, MAP and heart rate in all patients after therapy at 24 h corresponding to the circadian rhythm blood pressure. Furthermore, the trend of these variables synchronized themselves in the same period after 24 weeks of nicardipine therapy, with spectral patterns of blood pressure similar to those of normotensive subjects. This chronobiologic approach, by Maximum Entropy Method, may be used as an alternative statistical analysis to search for possible rhythmic behavior of ambulatory blood pressure data before and after pharmacological treatment in secondary hypertensive patients.
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PMID:Twenty-four-hour power spectral analysis by maximum entropy method of blood pressure in primary hyperaldosteronism. 820 12

In a randomly selected sample of 1579 individuals (male = 1334 and female = 245), aging from 14 to 65 years and representing all the socioeconomic groups of Multan, age (Yr), height (cm), weight (kg), BMI (kg/ml) and blood pressure (mmHg) were recorded. Height was measured on a Holtain portable stadiometer, weight on beam scale and blood pressure was recorded with sphygmomanometer as per auscultatory method. The correlation coefficient between different independent (age, height, weight and BMI) and dependent (SBP, DBP and MAP) parameters in male, female and total population were calculated and strong association between different parameters was observed (p < 0.001 or p < 0.05). The regression equations (simple and multiple) were worked out. The regression coefficient of different independent parameters with dependent parameters are higher in female except for height and age-weight and age-BMI had higher contribution in female as compared with that of male.
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PMID:Blood pressure and its correlates in the population of Multan, Pakistan. 900 92

1. We investigated the role of the autonomic nervous system (ANS) in cortisol induced hypertension using the technique of total autonomic blockade (AB). 2. Four healthy young males were given 50 mg cortisol 6 hourly for 6 days. On the day prior to, and the last day of, cortisol treatment, AB was produced using oral prazosin 1 mg, intravenous clonidine 300 micrograms, propranolol 0.2 mg/kg and atropine 2 mg. The adequacy of blockade was assessed using the haemodynamic response to Valsalva manoeuvre. 3. Cortisol produced a significant rise in systolic blood pressure (130 +/- 2 vs 110 +/- 1 mmHg, pre vs post cortisol; P < 0.01). On the final treatment day, AB augmented the increase in diastolic blood pressure (delta DBP), mean arterial pressure (delta MAP) and heart rate (delta HR) compared to the pretreatment day, delta DBP: 43 +/- 6 vs 17 +/- 4 mmHg, post vs pre cortisol, P < 0.005, delta MAP: 39 +/- 4 vs 14 +/- 4 mmHg, P < 0.001, delta HR: 45 +/- 5 vs 26 +/- 4 b.p.m., P < 0.05. The change in systolic blood pressure (delta SBP) was not statistically significant (32 +/- 4 vs 7 +/- 3 mmHg, P = 0.065). 4. These results suggest that the ANS exerts a modulating influence on the hypertensive effect of cortisol.
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PMID:Autonomic blockade amplifies cortisol-induced hypertension in man. 904 2

The effects of exercise detraining on resting finger arterial blood pressure (BP), the carotid-cardiac vagal baroreflex, and BP and heart rate (HR) responses to mental arithmetic and forehead cold exposure were studied in young (19 +/- 1.1 years) normotensive women with parental history of hypertension. Following 8 weeks of aerobic exercise for 25 min, 3 days week-1 at an intensity of 60% VO2peak, subjects ceased training for 6-8 weeks. After detraining, VO2peak (mL kg-1 min-1) was reduced by 11.5% (41.1 +/- 6.9 to 36.4 +/- 4.8) coincident with an approximately equal to 10% increase in submaximal exercise heart rate. Responses to the laboratory tasks were then compared. Detraining was accompanied by increases (P < 0.05) in resting systolic (SBP) (113.6 +/- 8.9 to 121.2 +/- 9.0), diastolic (DBP) (63.0 +/- 8.4 to 68.3 +/- 6.8), and mean arterial (MAP) (78.7 +/- 8.4 to 84.2 +/- 7.3) BP (mmHg). None of the above changes occurred in sedentary matched-control subjects. Systolic blood pressure was elevated during forehead cold exposure and MAP was elevated during mental arithmetic after detraining, but the rates of response and recovery for SBP, DBP and MAP were not altered by detraining. Despite higher submaximal exercise HR after detraining, HR responses to autonomic challenges, including the carotid-cardiac vagal baroreflex, were unchanged between training and detraining. Our results indicate that exercise detraining increases resting finger arterial BP in young normotensive women at risk for hypertension with no effects on the rate of response or recovery of heart rate and BP during autonomic tasks known to elicit sympathetic and carotid-cardiac vagal activities in this population. The use of auscultatory brachial artery pressures in a similar study of women diagnosed with hypertension will clarify the clinical meaning of our findings.
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PMID:Increased finger arterial blood pressure after exercise detraining in women with parental hypertension: autonomic tasks. 917 8

To prevent hypercalcemia in the treatment of secondary hyperparathyroidism, low calcium (L-Ca) dialysate is advocated. However, changes in ionized calcium (i-Ca) levels have a pivotal role in myocardial contraction and could influence blood pressure stability during dialysis. Recently, our group found in patients with normal cardiac function a significant decrease in blood pressure (decrease in systolic blood pressure [DSBP]: -13 mm Hg and decrease in mean arterial pressure [DMAP]: -7 mm Hg) during dialysis with L-Ca dialysate compared with high calcium (H-Ca) dialysate, and this was mainly related to a decreased left ventricular contractility with use of L-Ca dialysate. On the basis of these data, it could be expected that changes in i-Ca levels during dialysis are of more clinical importance in cardiac-compromised patients (CCpts), New York Heart Association classifications III and IV. In this study, the effects of L-Ca dialysate (1.25 mmol/L) and H-Ca dialysate (1.75 mmol/L) on arterial blood pressure parameters (systolic [SBP], diastolic [DBP], and mean arterial blood pressure [MAP]), heart rate, stroke distance (SDist), and minute distance (MDist) during 3 hours of a standardized ultrafiltration/hemodialysis (UF+HD) in nine CCpts was investigated. i-Ca levels increased significantly with H-Ca dialysate UF+HD, whereas there was no change with L-Ca dialysate. SBP, DBP, and MAP decreased statistically and clinically significantly during UF+HD with L-Ca dialysate and were significantly lower with the use of L-Ca dialysate compared with H-Ca dialysate. SDist and MDist decreased significantly with L-Ca dialysate, whereas there were no changes in SDist and MDist with H-Ca dialysate. The predialysis and postdialysis index of systemic vascular resistance (SVRI) was similar between L-Ca dialysate and H-Ca dialysate use. Between the two groups, there were no significant differences in changes in SVRI. From this study, we can conclude that changes in i-Ca levels are a very important determinant of the blood pressure response during UF+HD in CCpts, and this response is mediated by changes in myocardial contractility.
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PMID:Effect of dialysate calcium concentrations on intradialytic blood pressure course in cardiac-compromised patients. 966 33

The authors performed the study of the influence of spa treatment in Wysowa Health Resort on heart function in 294 subjects during their 24-day stay in sanatorium within three groups of patients: 28 with diabetes mellitus, 63 with arterial hypertension and a control group. Hemodynamic parameters were recorded by non-invasive impedance cardiography twice: in the first three days of spa treatment and again in the last three days of a 24-day stay. The following hemodynamic parameters were evaluated: SBP, DBP, MAP, CI, SVRI, IC, ACI, LCWI, EF, SI, EDI, TFC, HR. Relation of hemodynamic parameter changes on other measurable features was described in each group by correlation analysis. A small value of Pearson r coefficient proves a small relation among the examined variables. Both in the control group and in diabetic patients and also in patients with arterial hypertension, a spa treatment in Wysowa Health Resort does not show a significant influence to the examined hemodynamic parameters measured by impedance cardiography.
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PMID:[The influence of the Wysowa Spa treatment on heart function]. 1049 25

The effect of blood pressure control on urinary protein excretion was assessed in 24 benign essential hypertensive subjects (12 males and 12 females). There were 23 controls (11 males and 12 females). Mean ages were 55 and 53 years respectively. Twenty-four hours urine was collected from each subject before and after control of blood pressure, while the controls had only one 24 h urine sample collected. 24 h urinary albumin excretion was assessed using the Bromocresol Green Method. Control of blood pressure in the subjects took an average of eight weeks. Subjects were either given hydroflumethiazide, alpha-methyldopa and/or prazosin as required. Blood pressure was measured in the right arm at each visit and pill counting was used to assess the compliance with therapy. The average urinary albumin excretion was significantly higher in the hypertensive subjects than the normotensive controls (P < 0.05). The average urinary albumin excretion after control of blood pressure was also significantly lower than, before control of blood pressure (P < 0.02). There was no correlation between SBP, DBP, MAP, and 24 h urinary albumin excretion in both subjects and controls. This study has shown that control of blood pressure can reduce or reverse urinary albumin excretion in Nigerian hypertensives.
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PMID:The effect of anti-hypertensive therapy on urinary albumin excretion in Nigerian hypertensives. 1059 51

This study compared the dynamics of multiple systems during sleep with earlier results during waking rest. Three consecutive nights of data were collected from three healthy adults for 10 variables: left and right central EEGs; the nasal cycle (NC); beat-to-beat measures of CO, SV, HR, SBP, DBP, MAP, and hemoglobin-oxygen saturation. Time series analysis detected periods at 280-300, 215-275, 165-210, 145-160, 105-140, 70-100, and 40-65 min bins with the greatest spectral power in longer periods. We found significance across subjects with all parameters at 280-300, 105-140 (except left EEG power, left minus right EEG power, and HR), 70-100, and 40-65 min. Significant periods were reported earlier during waking for the NC, pituitary hormones, catecholamines, insulin, and cardiovascular function in five bins at 220-340, 170-215, 115-145, 70-100, and 40-65 min, with 115-145, 70-100, and 40-65 min common across all variables. These results suggest that lateral EEG power during sleep has a common pacemaker (the hypothalamus), or a mutually entrained pacemaker, with the cardiovascular and autonomic nervous systems (ANS), and that the waking ultradians of the neuroendocrine and fuel regulatory hormones may also be coupled to lateral EEG activity. Taken together these results present a new perspective for the Basic Rest-Activity Cycle and the physiology of the ANS-central nervous system during both waking and sleep.
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PMID:Ultradian sleep rhythms of lateral EEG, autonomic, and cardiovascular activity are coupled in humans. 1076 88

In young individuals, orthostatic intolerance is associated with marked increases in plasma epinephrine (EPI) concentrations and attenuated rises in plasma norepinephrine (NE) concentrations. This study investigated the cardiovascular, EPI and NE responses of healthy elderly males during orthostatic stress. Twelve men (68 +/- 1 yr) with a recent history of orthostatic hypotension and who exhibited orthostatic intolerance (HYPO) during 90 degrees head-up tilt (HUT) were compared with 12 men (69 +/- 1 yr) without a history of orthostatic hypotension and who remained normotensive (NORMO) throughout 90 degrees HUT. Beat-by-beat recordings of heart rate (HR), mean (MAP), systolic (SBP), diastolic (DBP), and pulse (PP) pressures were made throughout 90 degrees HUT. Blood samples obtained during supine rest and 90 degrees HUT were analyzed for changes in EPI and NE concentrations, hematocrit, hemoglobin and plasma volume. Compared to supine rest, orthostatic intolerance was characterized by significant reductions (p < 0.0001) in MAP, SBP, DBP, and PP. The HR, MAP, SBP, DBP, and PP at the termination of 90 degrees HUT was significantly lower (p < 0.0001) for HYPO than NORMO. The 90 degrees HUT position resulted in significant increases (p < 0.01) in NE for both HYPO and NORMO, with the rise in NE significantly lower (p < 0.05) in HYPO. There were no differences between groups regarding EPI concentrations at the termination of 90 degrees HUT. These results suggest that the magnitude of arterial pressure (AP) reduction does not influence the EPI response during orthostasis in healthy elderly men. However, marked reductions in AP, leading to orthostatic intolerance, are associated with inadequate increases in NE in these individuals.
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PMID:Norepinephrine and epinephrine responses during orthostatic intolerance in healthy elderly men. 1086 98

Blood pressure (BP) levels in the Finnish population are amongst the highest in the world, despite favourable changes at the national level in the past two decades. The study evaluates the familial aggregation of BP and the association of some environmental factors to the familial aggregation of BP as a primary epidemiological approach of the genetics of hypertension in a sample of families with young offspring from eastern Finland. Offspring aged 15 years were examined between 1996 and 1997 and their biological parents were examined between 1993 and 1994. A total of 224 children were invited, 184 families participated, from which 144 were included in the analysis with complete data. Systolic (SBP), diastolic (DBP) and mean (MAP) arterial BPs were the main outcome measurements. After the offspring's gender and body mass index (BMI) and the parent's age and BMI were controlled for, the mother/offspring correlation of SBP and the father/offspring correlation of MAP were statistically significant (r = 0.18, P = 0.039, n = 134 and r = 0.20, P = 0.048, n = 99, respectively). The additional adjustment for the parent's education and family history of acute myocardial infarction did not change these results. There was a higher proportion of offspring in the highest quartile of SBP and MAP when the mother had a history of hypertension (OR = 3.4, 95% CI = 1.4-8.5, n = 139, and OR = 2.6, 95% CI = 1.0-6.5, n = 139, respectively). The study confirmed the familial aggregation of BP. The consistent BP association between the mother and the offspring may indicate the key role of the mother in the primary prevention of hypertension.
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PMID:Familial aggregation of blood pressure: a population-based family study in eastern Finland. 1091 49


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