Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.11.18 (
MAP
)
7,412
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Triggering receptor expressed on myeloid cells 1
(
TREM-1
) is an important mediator of innate inflammatory responses in microbial infections and sepsis.
TREM-1
ligation on neutrophils (PMN) or monocytes results in the production of proinflammatory cytokines. Engagement of
TREM-1
induces the activation of
MAP
kinases as well as rapid Ca(2+) mobilization. However, a detailed understanding of
TREM-1
signaling pathways is currently lacking. We evaluated the
TREM-1
signaling hierarchy in monocytic cells and found that the acute myeloid leukemia cell line MUTZ-3 expresses
TREM-1
in a natural and functional manner. We compared essential signaling molecules of the
TREM-1
, TLR and NLR cascade in MUTZ-3 cells as well as primary monocytes or PMN by Western blot analysis. These studies confirmed the essential role of phosphatidyl inositide 3-kinase (PI3K) and p38MAPK in the
TREM-1
as well as the TLR or NLR cascade of monocytic cells. Importantly, PI3K and p38MAPK signals in monocytic cells both control Ca(2+) mobilization and are directly connected in the
TREM-1
signaling hierarchy, which contrasts previous results obtained in PMN. Taken together, our results indicate cell type-specific differences in the
TREM-1
signaling cascade and contribute to an enhanced understanding of the regulation of innate inflammatory responses.
...
PMID:Distinct signaling cascades of TREM-1, TLR and NLR in neutrophils and monocytic cells. 2428 14
