Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.11.18 (MAP)
 7,412 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The administration of ATP-MgCl2 may be of benefit in the treatment of shock by improving cellular metabolic function during resuscitation. Prior studies have reported data from hemorrhage models in which heparinized shed blood is returned both during shock and in resuscitation. The purpose of this study was to test the effects of ATP-MgCl2 therapy upon blood pressure and survival in an animal model of hemorrhagic shock utilizing crystalloid (Lactated Ringer's) resuscitation. Adult male Sprague-Dawley rats (340-360 g) were bled 27 cc/kg and maintained in shock for 45 min. At the end of the shock period, animals were resuscitated with crystalloid at twice the original hemorrhage volume. A blinded three-arm study was conducted and animals were assigned to receive either Lactated Ringer's (LR) with placebo, LR with MgCl2, or LR with ATP-MgCl2. Blood pressure was monitored throughout the procedure and survival time was noted. Post-resuscitation MAP was increased in animals treated with ATP-MgCl2. ATP-MgCl2 added to resuscitation significantly improved 72-h survival over that of control (LR) animals, and animals treated with MgCl2 alone.
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PMID:ATP-MgCl2 added to resuscitation improves survival in an experimental model of hemorrhagic shock. 774 Jan 96

To realize the simultaneous removal and recovery of phosphate and partial nitrogen from stale human urine, a series of lab-scale jar tests, adopting MgCl2 x 6H2O as precipitant, were conducted to study the influence of the molar ratio of Mg/PO4(3-)-P, pH, mixing speed, reaction time and precipitation time on MAP precipitation. The experiment results showed that the molar ratio of Mg/PO4(3-)-P was found to be a very important operating parameter to affect phosphorus recovery efficiency. When the molar ratio of Mg/PO4(3-)-P was above 1.3:1, the phosphorus recovery efficiency was above 95% and the residual phosphorous was less than 10 mg/L in the solution. Increasing pH with 10 mol/L NaOH solution could not increase the recovery phosphorus efficiency obviously. Without pH control, the optimal parameters of reaction time, precipitation time and mixing speed could be set at 20 min, 2.0 h and 120 r/min, respectively. To reveal the chemical characteristics of MAP products from human urine, three MAP product samples, with no pH adjustment and under the above optimal operation condition, were obtained at different Mg/PO4(3-)-P molar ratios of 1:1, 1.3:1 and 1.5:1, respectively, and analyzed with SEM, XRD and ICP instrumentation. These precipitates were identified as nearly pure struvite (12.62% of P, 5.71% of N and 9.91% of Mg) with the presence of trace calcium, potassium and sodium. The contents of phosphorus, nitrogen and magnesium in the precipitates were 13.54%, 5.34% and 9.01% (Mg/PO4(3-)-P = 1:1), 13.78%, 5.23% and 9.36% (Mg/PO4(3-)-P = 1.3:1), as well as 13.34%, 5.12% and 9.15% (Mg/PO4(3-)-P = 1.5:1), respectively.
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PMID:[Phosphorus removal and recovery from human urine with MAP crystallization]. 1826 83