Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.11.18 (
MAP
)
7,412
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A comparative model been designed to study a contribution of proteinkinase C-(PKC)-activated intracellular signaling pathways in generation of different contractile responses of vascular (tonic) and visceral (phasic) smooth muscles. We have determined that, in tonic smooth muscle, PKC mediates activation of
MAP
-kinases that phosphorylate key regulatory proteins of the contractile system, myosin light chain kinase and caldesmon, leading to upregulation of actomyosine motor activity. In contrast, the
MAP
-kinase activation is uncoupled from the contractile machinery in phasic smooth muscles, which also reveal high levels of myosin light chain kinase-related protein
KRP
that contributes to relaxation. Phosphorylation of
KRP
following activation of PKC or cyclic nucleotide-dependent protein kinases enhances the
KRP
activity and further contributes to relaxion in phasic smooth muscle. A possibility is discussed for exploitation of the comparative model described herein for investigation of specific role of other regulatory intracellular pathways in generation of vascular tonic contraction.
...
PMID:[Signaling regulatory mechanisms of the contractile activity of smooth muscle]. 1533 61
