Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.11.18 (
MAP
)
7,412
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Total spinal block by using 2% lidocaine 0.5 ml.kg-1 (10.0 mg.kg-1) was carried out in adult mongrel dogs. The effects of atropine 0.02 mg.kg-1, isoproterenol 0.5 mcg.kg-1, methoxamine 0.1 mg.kg-1 and ephedrine 0.5 mg.kg-1 to counteract circulatory changes by total spinal block were studied. Atropine did not exert any marked influence on circulatory system. Isoproterenol elevated HR, LV dp/dt max and CI temporarily, but did not decrease
MAP
and SVR.
Methoxamine
elevated
MAP
and SVR, but decreased CI. Ephedrine is a drug of choice for this situation because it elevated HR,
MAP
, LV dp/dt max and SVR.
...
PMID:[Changes in systemic circulation under induced total spinal block and choice of vasopressors]. 209 85
