Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.11.18 (MAP)
 7,412 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effectiveness of three different ventilator rates of artificial ventilation (30, 60 and 120/min) was studied in 32 preterm infants, all of whom were suffering from the Respiratory Distress Syndrome (16 were paralysed). Ventilator pressures, I:E ratio and MAP were kept constant at each rate. Increase in rate from 30 to 60 and to 120/min was well tolerated and not associated with episodes of hypotension. The only significant improvement in oxygenation was amongst the non-paralysed infants and at a rate of 120/min (p less than 0.01) this was associated with synchronous respiration. Two different ventilators were used in the study and a significant change in PaCO2 (reduction) occurred only in non-paralysed infants ventilated at a rate of 120/min by Sechrist ventilators (p less than 0.05). This difference may be a direct reflection of differences in ventilator performance at fast rates.
 ...
PMID:Comparison of different rates of artificial ventilation in preterm neonates with respiratory distress syndrome. 331 May 13

Variations in PEEP with concomitant changes of DPP while MAP, PIP, flow, FIO2, and ventilator rate remained constant were investigated in nine neonates with RDS during the first and second days of life. After stabilization on baseline ventilator settings, PEEP was increased by 3 cm of H2O and DPP decreased in order to maintain balance MAP. Following a return to baseline settings, the PEEP was decreased by 3 cm of H2O and DPP increased sufficiently to maintain constant MAP. Arterial PaO2, PaCO2, pH, blood pressure, heart rate and a/APO2 ratios were measured before, during, between, and after the experimental conditions. Analysis revealed no significant changes in PaO2, a/APO2, blood pressure, or heart rate during baseline or experimental conditions. PaCO2 decreased significantly when PEEP was decreased and DPP increased, both on day 1 (37.2 +/- 2.4 vs 41.4 +/- 2.3 torr; P less than 0.025) and day 2 (42.1 +/- 2.6 vs 46.8 +/- 2.0 torr; P less than 0.05). Changes in pH were inversely related to PaCO2 changes. This study confirms the importance of MAP in determining oxygenation in newborn infants with RDS. However, ventilation was significantly affected by variation in PEEP and DPP despite a constant MAP.
 ...
PMID:Mean airway pressure--significance during mechanical ventilation in neonates. 678 18