Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.11.18 (
MAP
)
7,412
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This review highlights the emerging roles of the
Pellino
family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of
MAP
kinases and transcription factors. The functional importance of the
Pellino
family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of
Pellino
proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of
Pellino
biology begins to fill some long-standing voids in our understanding of TLR signalling.
...
PMID:The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. 1902 6
