Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.11.18 (MAP)
 7,412 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of diltiazem (CRD-401) on coronary collaterals was studied in the dog. The anterior descending branch of the left coronary artery was occluded for 4 to 6 weeks by an ameroid constrictor. In these dogs, the retrograde flow (RF) from the peripheral coronary artery and peripheral coronary pressure (PCP) were significantly higher than those in acute coronary-ligated dogs, suggesting the development of large supraepicardial intercoronary anastomoses. Diltiazem (100 mug/kg i.v.) increased circumflex blood flow (CBF) for several min, while nitroglycerin (10 mug/kg i.v.) increased CBF transiently after which CBF decreased to below control values. Diltiazem (100 mug/kg) and nitroglycerin (10 mug/kg) increased RF/MAP (mean aortic pressure) and PCP/MAP and these increases lasted longer than that of CBF. Diltiazem also increased RF in doses of 100 mug/kg or 20 mug/kg/min. Therefore, diltiazem possesses the property of dilating coronary collaterals thus causing redistribution of intramyocardial blood flow. In acute preparations, however, both diltiazem and nitroglycerin showed no significant changes in PCP/MAP and RF/MAP.
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PMID:Effects of diltiazem (CRD-401) on developed coronary collaterals in the dog. 81 Jun 10

The doublecortin-like (DCX) domains serve as protein-interaction platforms. DCX tandem domains appear in the product of the X-linked doublecortin (DCX) gene, in retinitis pigmentosa-1 (RP1), as well as in other gene products. Mutations in the human DCX gene are associated with abnormal neuronal migration, epilepsy, and mental retardation; mutations in RP1 are associated with a form of inherited blindness, while DCDC2 has been associated with dyslectic reading disabilities. Motivated by the possible importance of this gene family, a thorough analysis to detect all family members in the mouse was conducted. The DCX-repeat gene superfamily is composed of eleven paralogs, and we cloned the DCX domains from nine different genes. Our study questioned which functions attributed to the DCX domain, are conserved among the different members. Our results suggest that the proteins with the DCX-domain have conserved and unique roles in microtubule regulation and signal transduction. All the tested proteins stimulated microtubule assembly in vitro. Proteins with tandem repeats stabilized the microtubule cytoskeleton in transfected cells, while those with single repeats localized to actin-rich subcellular structures, or the nucleus. All tested proteins interacted with components of the JNK/MAP-kinase pathway, while only a subset interacted with Neurabin 2, and a nonoverlapping group demonstrated actin association. The sub-specialization of some members due to confined intracellular localization, and protein interactions may explain the success of this superfamily.
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PMID:Common and divergent roles for members of the mouse DCX superfamily. 1662 14