Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
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Human Gene/Protein
chondroitinsulfatase 12.8
hyaluronidase 12.8
HYALP1 12.8
LUCA-1 12.8
HYAL4 12.5
Sperm adhesion molecule 1 12.2
HYAL3 12.1
Hyaluronidase 12.1
Hyal-1 12.1
hyaluronidase 1 11.9
PH-20 11.9
HYAL-1 11.7
HYAL1 11.7
Hyal-3 11.6
HYAL2 11.6
Hyal-2 11.4
Hyaluronan synthase 11.3
hyaluronidase 2 11.3
MEA6 11.2
alkaline phosphomonoesterase 10.5
dimethyladenosine transferase 10.4
Apoptosis repressor with CARD 10.4
elongation of very long chain fatty acids protein 10.4
Alkaline phosphomonoesterase 10.2
chondroitinase 10.2
HAS3 10.1
HA synthase 3 9.9
interferon-induced protein 44 9.9
collagen, type I, alpha 1 9.8
migration stimulating factor 9.8
PO42 9.8
hyaluronan synthase 9.5
TMEM2 9.4
hyaluronan binding protein 9.4
Chondroitinase 9.4
zinc finger protein 423 9.3
transmembrane protein 2 9.3
HAS1 9.2
hyaluronan synthase 2 9.2
HAS2 9.1
hyaluronan receptor 9.1
MUC-3 9.1
FUS2 8.9
Layilin 8.9
chondroitin polymerizing factor 8.9
arginine vasopressin V2 receptor 8.9
HKR1 8.9
Coagulation factor IX 8.8
hyaluronan synthase 1 8.6
KIAA1199 8.6
hyaluronan-mediated motility receptor 8.5
CSS3 8.5
MUC5 8.4
HA4 8.4
CD44 protein 8.4
N-acetylglucosamine-6-phosphate deacetylase 8.4
beta-1,3-galactosyltransferase 8.4
acrosin inhibitor 8.3
TCH 8.3
S-laminin 8.2
hyaluronan-binding protein 8.2
inter-alpha 8.2
epididymal secretory protein 8.1
MGEA5 8.1
soluble CD44 8.0
CANT1 8.0
RHAMM 8.0
anti-elastase 8.0
HLX 7.9
RNF5 7.8
sperm surface protein 7.8
PXE 7.8
collagenase 7.8
ICH-1L 7.8
link protein 7.7
interphotoreceptor matrix 7.7
HSA3 7.7
ABC 7.7
testis protein 7.7
HSA1 7.7
tRNA-Arg 7.6
CD44 molecule 7.6
GNAI2 7.5
Brevican 7.5
Bone morphogenetic protein 7 7.5
K38 7.5
brevican 7.5
JLP 7.4
cyl 7.4
keratin 13 7.4
versican 7.4
TSG-6 7.3
cytokeratin 16 7.3
LTBP-2 7.3
B-5 7.3
5' nucleotidase 7.3
ATDC 7.3
HRH1 7.3
proteoglycan core protein 7.3
microfibril-associated glycoprotein 7.3
PG-Lb 7.3
neurocan 7.2
ADAM2 7.2
PEP1 7.2
CS-2 7.2
CBPP 7.2
HID 7.2
TIAR 7.2
lung surfactant protein D 7.2
Eppin 7.2
NSP5 7.2
CD44 7.1
GMP synthase 7.1
TFPI2 7.1
WWOX 7.1
TEX101 7.1
UDP-glucose 6-dehydrogenase 7.0
Caspase-14 6.9
inter-alpha-trypsin inhibitor 6.9
K36 6.9
Arylsulfatase A 6.9
Hemopexin 6.9
glutaminyl cyclase 6.9
AGF 6.9
semenogelin I 6.9
CD168 6.8
hyaluronic acid receptor 6.8
GMF 6.8
chitobiase 6.8
C1QBP 6.8
sperm protein 6.8
Hpa1 6.8
phosphomonoesterase 6.8
CLS 6.8
proteoglycan 6.8
ACR 6.7
aquaporin 3 6.7
2-O-sulfotransferase 6.7
cartilage-derived 6.7
ACPT 6.7
transglutaminase 1 6.7
PLA1 6.7
Del1 6.7
LDH-X 6.6
laminin-binding protein 6.6
endo-beta-N-acetylglucosaminidase 6.6
MAGP 6.6
proacrosin 6.6
exostosin 6.6
ADPase 6.6
phosphacan 6.6
espin 6.6
deoxyribonuclease 6.6
large aggregating proteoglycan 6.5
glucosamine 6.5
hexosaminidase A 6.5
KEL 6.5
caspase-14 6.5
ST18 6.5
SP-10 6.5
more...
Disease
Hyaluronidase allergy 12.8
MPS IX 11.2
Vitreous liquefaction 10.4
Stomal prolapse 9.8
problem with drugs 9.6
bee sting allergy 9.3
Swine erysipelas 9.2
Airsacculitis 9.1
Collagenomas 8.9
Cystitis cystica 8.7
Ligneous conjunctivitis 8.7
Parachordoma 8.6
stage IV pancreatic cancer 8.5
synchysis 8.5
epithelial mesothelioma 8.1
lung sarcoma 8.1
localized malignant mesothelioma 7.9
Jaagsiekte 7.8
Myrmecia 7.8
Meige 7.2
Streptococcus pneumoniae meningitis 7.0
Teratocarcinoma 7.0
nRNA 6.9
Myometrium 6.8
akinesia 6.7
paraphimosis 6.7
vitreous detachment 6.7
periodontosis 6.6
Infection induced 6.6
Necrobiosis lipoidica 6.5
3rd nerve palsy 6.5
Myxofibrosarcoma 6.5
Skin toxicity 6.5
scleredema 6.3
mucinosis 6.3
VRSA 6.2
Acquired von Willebrand syndrome 6.2
Oral submucous fibrosis 6.1
acute pharyngitis 6.1
CLS 6.1
Reinke's edema 6.0
Intravenous leiomyomatosis 6.0
Acute rheumatic fever 6.0
adenomatoid tumor 6.0
Morquio 5.9
leeches 5.9
puerperal fever 5.8
trisomy 15 5.8
adenocarcinoma of the bladder 5.8
IDD 5.8
bladder neoplasm 5.8
mucopolysaccharidosis 5.7
meningococcal infection 5.7
follicular mucinosis 5.7
Sanfilippo 5.6
chronic conjunctivitis 5.6
vitreous humor 5.6
gas gangrene 5.5
HRA 5.5
erysipelas 5.5
malignant mesothelioma 5.5
Aeromonas hydrophila infection 5.4
Erysipelothrix 5.4
high risk pregnancy 5.4
arachnoiditis 5.4
Blight 5.4
AA1 5.3
chondrosarcoma 5.3
orbital cellulitis 5.2
Papillomas 5.2
Dedifferentiation 5.2
chronic leukemia 5.2
coryza 5.1
Sander 5.1
eye infection 5.1
PMD 5.1
Erysipelothrix 5.1
fibrocystic breast disease 5.1
acute glomerulonephritis 5.0
TNS 5.0
staphyloma 5.0
Scheie 5.0
Brucella canis 4.9
normocytic anemia 4.9
puerperal sepsis 4.9
skin ulcers 4.8
parasympathomimetic 4.8
chronic cystitis 4.8
epididymis 4.8
CTM 4.8
mesothelioma 4.8
pseudoxanthoma elasticum 4.8
streptococcal infection 4.8
voice disorder 4.8
pasteurellosis 4.8
Mesothelioma 4.8
Enzyme inhibition 4.8
metastatic pancreatic cancer 4.8
radiation carcinogenesis 4.7
diffuse goiter 4.7
high-grade lymphomas 4.7
collagen disease 4.7
local cancer 4.6
laryngospasm 4.6
Dupuytren 4.6
myxedema 4.6
antidiuresis 4.6
ocular herpes 4.6
bilateral cataracts 4.6
scarlet fever 4.6
GM1 gangliosidosis 4.5
pyonephrosis 4.5
trichiasis 4.5
serous otitis media 4.5
MNS 4.4
infectious hepatitis 4.4
Graves' ophthalmopathy 4.4
Hurler 4.4
hepatic neoplasm 4.3
corneal dystrophy 4.3
Sanfilippo syndrome 4.3
urticaria pigmentosa 4.3
caruncle 4.3
Tuberculous meningitis 4.3
large cell carcinomas 4.2
Bielschowsky 4.2
morphea 4.2
trismus 4.2
Rous sarcoma 4.2
SMC 4.2
complicated pregnancy 4.2
enchondroma 4.1
pharyngitis 4.1
Peyronie's disease 4.1
renal clear cell carcinoma 4.1
sclera 4.1
MPS VI 4.1
Dermal 4.0
ischemic optic neuropathy 4.0
asbestosis 4.0
impetigo 4.0
MSD 4.0
WRN 4.0
mastocytoma 4.0
rind 4.0
Opiates 4.0
malignant pleural effusion 4.0
testicular atrophy 4.0
FBS 4.0
tracheobronchitis 3.9
Chondrosarcoma 3.9
Chondrosarcoma 3.9
Acanthamoeba keratitis 3.9
collagen disease 3.9
corneal edema 3.9
papillary tumor 3.8
staphylococcus 3.8
fibrosarcoma 3.8
Adhesion 3.8
HHS 3.8
more...
Symptom
Localized myxedema 11.8
Local reaction 8.6
localized erythema 7.8
Stinging 7.0
painful swallowing 6.7
catarrh 6.2
localized edema 6.0
Crushing 5.8
periorbital edema 4.8
Postoperative nausea and vomiting 4.7
prostatism 4.6
Hudson 4.3
muscle stiffness 4.1
livedo 4.0
Halo 3.9
Stiffness 3.8
stomach pain 3.8
skin damage 3.8
sciatica 3.7
hyperesthesia 3.7
POA 3.7
HSA 3.5
erythema 2.9
anesthesia 2.7
hot flashes 2.7
muscle rigidity 2.7
ophthalmoplegia 2.6
decreased appetite 2.6
analgesia 2.6
Mills 2.4
flushing 2.4
Sedation 2.4
agitation 2.4
discomfort 2.3
collapse 2.3
discomfort 2.2
thinning 2.1
oliguria 1.9
cachexia 1.9
lethargy 1.9
paresis 1.8
leg pain 1.8
tense 1.7
flank pain 1.7
functional recovery 1.6
pain 1.5
pallor 1.5
numbness 1.4
hypercapnia 1.4
asthenia 1.4
sore throat 1.3
knee pain 1.3
hypotonia 1.2
acute abdomen 1.2
colic 1.1
dizziness 1.1
spasticity 1.1
tremor 0.9
spasm 0.9
acute pain 0.8
cough 0.8
back pain 0.8
pelvic pain 0.8
apathy 0.8
myoclonus 0.7
hypothermia 0.7
nausea 0.6
nausea and vomiting 0.5
paresthesia 0.5
starvation 0.5
acidity 0.5
shortness of breath 0.4
ENT 0.4
chest pain 0.3
respiratory distress 0.1
exhaustion 0.0
dyspnea -0.0
arthralgia -0.1
ataxia -0.2
syncope -0.4
splenomegaly -0.5
low back pain -0.5
insomnia -0.6
vomiting -0.6
weakness -0.9
anorexia -1.0
Welt -1.2
fatigue -1.3
diarrhea -1.5
seizures -2.0
headache -2.0
abdominal pain -2.2
Drug
Hylenex recombinant 12.8
Hyaluronidase 12.1
Hyaluronidase 12.1
Zephiran chloride 11.8
Antirabies serum 10.8
Berberine sulfate 9.8
Methacholine chloride 9.3
Citric Acid 9.2
mepivacaine hydrochloride 8.9
Arfonad 8.8
Cupric sulfate 8.8
Arfonad 8.2
Berberine chloride 8.0
Citanest 8.0
Citanest 8.0
Acemetacin 7.7
ABC 7.7
Gold sodium thiomalate 7.4
Sodium hyaluronate 7.4
Sodium thiosulfate 7.2
Triprolidine 7.1
Marcaine 7.0
Pronase 6.9
Oxfendazole 6.8
Areca 6.7
Tween 85 6.7
Chymopapain 6.6
CLS 6.6
Tannic acid 6.5
Butorphanol 6.3
Cellulose acetate 6.3
Hydroxyethylstarch 6.1
Lacidipine 6.0
Ulinastatin 5.9
Lacidipine 5.8
C3F8 5.7
Xylocaine 5.3
Navelbine 5.2
Bupivacaine 5.2
Mitomycin-C 5.1
Phosphoramidon 5.0
Estriol 5.0
Calcium chloride 4.9
Herceptin 4.9
NAG 4.9
CTM 4.8
Magnevist 4.8
Oxacillin 4.7
Papain 4.6
Palmitoyl 4.6
Nimesulide 4.5
balanced salt solution 4.5
CTM 4.4
Optison 4.3
Filgrastim 4.3
Dalteparin 4.3
Fraction 4.2
Lugol 4.1
CEC 4.1
Filgrastim 4.1
Botox 4.1
Vinorelbine 4.0
Paraffin 4.0
Trifluoperazine 4.0
MEA 4.0
Ringer's solution 3.9
Monensin 3.9
Prednisolone 3.8
Thyroglobulin 3.8
Citric acid 3.8
Luteinizing 3.7
Adalimumab 3.7
LMWH 3.7
Sinemet 3.7
Fluorescein 3.7
Indocyanine green 3.6
Salicylate 3.6
Streptokinase 3.6
Rituximab 3.6
Trib 3.3
ADR 3.3
Tocopherol 3.3
Gel 3.2
Fluorescein 3.2
Vitamin A 3.2
Docetaxel 3.0
Adenosine triphosphate 2.9
NaI 2.9
NaI 2.9
NaI 2.9
NaI 2.9
Aprotinin 2.9
Histamine 2.9
CaCl2 2.9
Cetuximab 2.9
Diphenhydramine 2.7
Galactose 2.7
CaCl2 2.7
CaCl2 2.7
Hypaque 2.6
nitroglycerin 2.6
DMAP 2.6
Infliximab 2.6
Retinoic acid 2.6
Infliximab 2.6
Adriamycin 2.6
TAT 2.5
Albumin 2.5
Hypaque 2.5
Serum albumin 2.5
Scopolamine 2.4
NBT 2.4
HCG 2.4
Phenytoin 2.4
BLM 2.4
Meth 2.4
FeCl3 2.3
Vitamin K 2.3
CAM 2.2
IPM 2.2
Allergen 2.2
DM1 2.1
Taxol 2.1
citric acid 2.1
Gelatin 2.0
PTC 2.0
ROS 2.0
Bevacizumab 2.0
TTC 1.9
Fructose 1.9
p75 1.8
Spectrum 1.8
lysine 1.7
Indomethacin 1.7
ACT 1.7
G418 1.6
Glycerol 1.6
L-tyrosine 1.5
lactose 1.5
ampicillin 1.5
Leaf 1.5
Clonidine 1.5
EE2 1.4
Forskolin 1.4
Alliance 1.4
DNase I 1.3
ETA 1.3
Alanine 1.3
CSF 1.3
Biopolymers 1.3
IFN-beta 1.2
MAP 1.1
ADM 1.1
Ethanol 1.1
Atropine 1.1
MRC 1.0
Kenyan 1.0
Dermatol 0.9
ascorbate 0.8
Asn 0.8
more...
Enzyme
chondroitinsulfatase 12.8
hyaluronidase 12.8
hyaluronidase 12.3
EC 2.4.1.152 10.8
coccolysin 10.8
chondro-4-sulfatase 10.6
chondroitinase AC 10.5
chondroitinase B 10.4
chondroitinase 10.1
hyaluronate lyase 10.1
chondroitinase 10.0
EC 2.4.1.214 9.6
xanthan lyase 9.3
deuterolysin 9.2
endo-beta-galactosidase 9.2
chondro-6-sulfatase 9.2
N-acetylglucosamine-6-sulfatase 9.1
C5a peptidase 9.1
chondroitin ABC lyase 9.1
phosphoamidase 9.1
glucuronan lyase 9.1
heparinase 8.8
acrosin 8.7
N-acetylgalactosaminidase 8.5
glycosulfatase 8.4
heparitinase I 8.4
N-acetylglucosamine-6-phosphate deacetylase 8.3
endo-alpha-N-acetylgalactosaminidase 8.2
sphingomyelinase D 8.0
ScpA 7.9
beta-D-fucosidase 7.8
carnosine synthetase 7.5
destabilase 7.5
nicotinamide adenine dinucleotide glycohydrolase 7.4
EC 2.7.7.9 7.4
collagenase 7.4
phospholipase A1 7.3
endo-beta-galactosidase 7.2
phosphatidylinositol phospholipase C 7.2
CBPP 7.1
clostripain 7.1
deoxyribonuclease 7.1
deoxyribonuclease 7.0
UDP-glucose dehydrogenase 7.0
glutaminyl cyclase 7.0
beta-glycerophosphatase 7.0
GMP synthase 7.0
APS kinase 6.9
Alternating 6.9
iduronate-2-sulfatase 6.9
astacin 6.8
cathepsin F 6.8
FucT 6.5
hexosaminidase 6.5
DNase 6.4
arginine kinase 6.3
neuraminidase 6.3
ADPase 6.2
tyrosine decarboxylase 6.2
neuropathy target esterase 6.2
elastase 6.1
5'-nucleotidase 6.0
DAP II 6.0
aspartylglucosaminidase 6.0
PI-PLC 5.9
ficin 5.9
beta-glucuronidase 5.9
endo-N 5.9
sorbitol dehydrogenase 5.9
papain 5.8
sialidase 5.8
carnosinase 5.8
phospholipase A2 5.8
glycoprotease 5.8
T-protein 5.7
beta-xylosidase 5.7
IgA1 protease 5.7
SpeB 5.6
NAD glycohydrolase 5.6
GMP synthetase 5.5
trypsin 5.5
alpha-N-acetylgalactosaminidase 5.4
beta-glucosidase 5.4
sulfatase 5.4
apyrase 5.3
CAO 5.3
acid phosphatase 5.2
beta-glucosidase 5.2
cathepsin C 5.2
N-acetylglucosaminyltransferase I 5.1
chymopapain 5.1
arylsulfatase A 5.1
chymopapain 5.0
alanyl-tRNA synthetase 5.0
beta-amylase 5.0
venom phosphodiesterase 4.9
oxytocinase 4.9
arylsulfatase 4.8
alanine aminopeptidase 4.8
bile salt hydrolase 4.8
alpha-mannosidase 4.8
SOR 4.8
proteinase K 4.8
nucleotidase 4.7
lysin 4.7
chymotrypsin 4.6
endoglycosidase H 4.5
pepsin 4.5
plasmin 4.5
tyrosinase 4.4
bromelain 4.3
ribonuclease 4.3
ribonuclease 4.3
pectin methylesterase 4.3
alpha-L-fucosidase 4.2
alpha-L-iduronidase 4.2
alpha-glucosidase 4.2
legumain 4.2
dextranase 4.1
alpha-amylase 4.1
caspase-2 4.1
lipase 4.1
galactose oxidase 4.1
endoproteinase Glu-C 4.0
DNase II 4.0
Protein 2 4.0
chymase 4.0
RNase 3.9
lipoxygenase 3.9
cholesterol esterase 3.9
chitinase 3.9
lysostaphin 3.8
RNase 3.8
PNGase F 3.8
cathepsin D 3.7
p80 3.7
lysozyme 3.6
ADH 3.6
beta-galactosidase 3.6
PTA 3.6
alpha-galactosidase 3.6
phosphodiesterase 3.6
succinic dehydrogenase 3.6
pectate lyase 3.5
arginine decarboxylase 3.5
alkaline phosphatase 3.5
15-hydroxyprostaglandin dehydrogenase 3.5
TPP 3.4
kallikrein 3.4
enterokinase 3.4
glucose oxidase 3.4
neutrophil elastase 3.3
cholesterol oxidase 3.3
type III procollagen 3.3
transglutaminase 3.3
tryptase 3.3
phospholipase C 3.3
SOR 3.3
6-phosphogluconate dehydrogenase 3.3
6-phosphogluconate dehydrogenase 3.3
more...
Compound
1,4-Butanediol diglycidyl ether 11.2
cis-Hinokiresinol 11.2
Hydrangenol 10.9
C7H9NO 10.8
1-benzyl-1H-indole 10.8
4-phenyl-4-piperidinol 10.2
Rapanone 10.2
octyl acrylate 9.9
Berberine sulfate 9.8
Berberine sulfate 9.8
Chondroitin sulfate A 9.5
hyaluronic acid 9.2
GalNAc4S 9.1
Surfynol 8.8
Neuraminic acid 8.8
Rhaponticin 8.7
Naphthazarin 8.5
Naphthazarin 8.4
Trisaccharides 8.4
Adipic acid dihydrazide 8.4
CGP 52608 8.4
TRU 8.3
TCH 8.2
Chondroitin 8.1
Stains-all 8.0
Chondroitin sulfate 8.0
2-hydroxypropanoic acid 7.9
Berberine chloride 7.8
Dermatan sulfate 7.8
2-hydroxypropanoic acid 7.8
2-hydroxypropanoic acid 7.8
2-hydroxypropanoic acid 7.8
2-hydroxypropanoic acid 7.8
2-hydroxypropanoic acid 7.8
hexuronic acid 7.7
ICI 164384 7.7
Azure A 7.7
hexuronic acid 7.7
hexuronic acid 7.7
hexuronic acid 7.6
DNAP 7.6
Dermatan sulfate 7.6
Pyranine 7.5
Decaris 7.5
Escin 7.5
Escin 7.5
Chicago Sky Blue 6B 7.4
Pyranine 7.4
D-glucuronic acid 7.4
keratan sulfate 7.4
Ehrlich's reagent 7.3
2-hydroxypropanoic acid 7.3
nitrous acid 7.3
Collagenase 7.1
4-methoxycinnamic acid 7.1
1-methyltryptophan 7.0
iodic acid 7.0
iodic acid 6.9
Ruthenium red 6.9
L-chicoric acid 6.8
4-Methylumbelliferone 6.8
CLS 6.7
PEK 6.7
DPPS 6.7
Glucosamine 6.7
Diisopropyl fluorophosphate 6.6
DDMU 6.6
iduronate 6.5
Pinocembrin 6.5
Butorphanol 6.4
Bromophenol Blue 6.3
Punicalagin 6.3
DMAB 6.3
D-glucuronate 6.3
Prilocaine 6.2
Sodium lactate 6.2
D-glucosamine 6.1
Sodium deoxycholate 6.1
Heparan sulfate 6.1
2-aminobenzamide 6.1
Copper sulfate 6.1
Esculin 6.1
B 5 6.0
fructose-6-P 5.9
Triamcinolone acetonide 5.9
Embelin 5.9
BZT 5.8
Triton WR-1339 5.8
Melittin 5.8
BAPN 5.7
butyl nitrite 5.7
GalNAc 5.7
Trypsin 5.7
PCMB 5.6
PCMB 5.6
PCMB 5.6
PCMB 5.5
Caryophyllene 5.5
Toluidine blue 5.5
Flavonol 5.5
benzenesulfonyl fluoride 5.5
BRA 5.5
Paraformaldehyde 5.4
PAPS 5.4
Gossypol 5.3
Gossypol 5.3
1,2-ethanediamine 5.3
UDP-N-acetylgalactosamine 5.3
1,2-ethanediamine 5.3
Sesamin 5.2
MNT 5.2
Pectate 5.2
Bupivacaine 5.2
SC-1 5.2
SC-1 5.2
GlcNAc 5.2
MGA 5.1
Mr 30 5.1
Aristolochic acid 5.1
Paraformaldehyde 5.1
NH4OH 5.0
Farnesol 5.0
PAS 5.0
Phosphoramidon 5.0
UDP-GlcNAc 5.0
Potassium chloride 5.0
isopentane 4.9
4-chlorobenzyl 4.9
Triamcinolone 4.9
1,4-butanediol 4.8
Allergan 4.8
CuS 4.8
1,3-propanediamine 4.8
sulfate 4.8
HBC 4.8
Azan 4.8
Oxacillin 4.8
SKF 525A 4.8
Digitonin 4.8
CAA 4.8
tetradecyl 4.7
tetradecyl 4.7
Linalool 4.7
N-acetyl-D-glucosamine 4.7
SAN 4.7
MgCl2 4.7
Cyanine 4.7
BSH 4.7
Ruthenium 4.6
Ruthenium 4.6
Leupeptin 4.6
1H-1,2,4-triazole 4.6
Protamine 4.6
TCM 4.5
TCM 4.5
Estriol 4.5
Mannose 4.5
Glycine, 4.5
Akron 4.5
Spiperone 4.5
more...