Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

24 group C and 31 group G streptococcal strains were studied examining the production of extracellular nucleases, NADase, hyaluronidase and streptolysin O. 5 mucous strains were characterized by diminished growth and lack of hyaluronidase and NADase-production. Regarding the other strains of group C, one half produced nuclease-activity whereas only one out of ten group G streptococci did. Group G streptococci were more active in the production of NADase and hyaluronidase than group C streptococci. The levels of streptolysin O in groups C and G are comparable.
 ...
PMID:[Release of extracellular metabolic products by Streptococci groups C and G]. 629 26

Group A streptococci strains were grown in broth containing subminimal inhibitory concentrations of chloramphenicol, erythromycin and penicillin, and tested for possible changes in colonial morphology, activity and amount of cellular and extracellular components. The following components were tested: T protein, M protein, opacity factor, lipoteichoic acid, hyaluronic acid, streptolysin S, streptolysin O, DNase, hyaluronidase and NADase. Sub-MICs of these drugs produced variable changes in the bacteria. They increased the amount of hyaluronic acid and hyaluronidase, decreased the amount of M protein, and enhanced phagocytosis and the release of lipoteichoic acid. The results indicate that sub-MICs of chloramphenicol, erythromycin and penicillin may affect the pathogenicity and toxinogenicity of group A streptococci.
 ...
PMID:Effects of subminimal inhibitory concentrations of chloramphenicol, erythromycin and penicillin on group A streptococci. 676 Nov 13