Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

ECG, histological, and histochemical examinations on a model of experimental myocardial infarction showed that hyaluronidase administration leads to a decrease in the sum of elevation of the ST segment and the number of points (NST) at which this elevation is recorded, acceleration of healing processes in the affected zone, and to activation of respiratory enzymes and the pentosophosphate shunt in some of the fibres of the peri-infarction zone.
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PMID:[Effect of hyaluronidase on morphological changes in the myocardium in experimental myocardial infarct]. 43 87

The effect of hyaluronidase on myocardial ischemic injury was examined in 13 patients with acute myocardial infarction, and the results were compared with 11 patients who did not receive hyaluronidase. A 35-electrode precordial mapping method was used to assess the rate of resolution of ST segment elevations. In the 11 control patients, the sum of ST segment elevations (sigmaST) fell after 2 hours to an average of 93.5% plus or minus 17.3% (SEM) and after 24 hours to 89.6% plus or minus 7.6% of the initial values, while the number of electrodes exhibiting ST segment elevations exceeding 0.1 mV (NST) fell to 98.0% plus or minus 12.3% and 94.3% plus or minus 10.4% of the initial values respectively. In the hyaluronidase-treated group, at the same time sigmaST fell significantly more (P less than 0.05), to 54.1% plus or minus 5.0% and 51.3% plus or minus 11.8% and NST was also more markedly reduced (P less than 0.05) to 50.7% plus or minus 7.8% and 50.1% plus or minus 12.4%, thus indicating that hyaluronidase can accelerate the reduction of myocardial ischemic injury in patients with acute myocardial infarction.
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PMID:Effects of hyaluronidase administration on myocardial ischemic injury in acute infarction. A preliminary study in 24 patients. 111 65