Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Previous studies have shown that bovine retinas incubated with [3H]galactose incorporated it, unmodified, into large molecules. Light and electron microscope autoradiography showed a significant proportion of the label to be in cone inner segments, and pulse-chase studies showed it was subsequently transported to the synaptic pedicles. In this report, evidence is presented to show that the galactose-labelled macromolecules are resistant to hydrolysis by proteolytic enzymes, testicular hyaluronidase, chondroitinase ABC, beta-glucosidase and beta-glucuronidase, but are readily degraded by alpha-amylase and beta-galactosidase, and to a lesser extent by beta-amylase. Treatment with alpha-amylase also leads to specific removal of radioactivity from cone inner segments and pedicles, as judged by light-microscopic autoradiography. These studies appear to indicate that the cone-specific galactose label is in glycogen or glycogen-like molecules.
 ...
PMID:D-[3H]galactose incorporation into glycogen in retinal cone cells. 231 72

The function of Paramecium alveolar system underlying the cell membrane has been studied. Permeability and structure of cell membrane, alveolar membranes and alveoli following alpha-amylase, beta-amylase, phospholipase C and hyaluronidase treatment has been examined. It is demonstrated that droplets of polycationic dye, ruthenium red, have been trapped within the alveoli whereas the dye was also bound by the outer and inner alveolar membrane. This suggest the presence of anionic sites capable to bind cationic compounds within the alveoli. It may be concluded that the alveolar system in Paramecium is functioning as a barrier protecting the cell against the chemicals added from the outside when the cell membrane separating the cytoplasm from the medium is impaired.
 ...
PMID:Alveolar system of Paramecium. I. Trapping polycationic dye as a result of membrane impairment. 617 Nov 30