Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.36 (
hyaluronidase
)
4,606
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Seven inhibitors of the sperm enzyme
hyaluronidase
were tested at nonspermicidal concentrations for their vaginal contraceptive activity in rabbits. Five of these compounds are marketed antiinflammatory agents and the other two were synthesized. Most of the agents showed contraceptive activity. Of the antiinflammatory agents, phenylbutazone and oxyphenbutazone were particularly potent. Besides being
hyaluronidase
inhibitors, these compounds are also cyclooxygenase (
prostaglandin synthetase
) inhibitors; based on other in vitro data, their primary effect on spermatozoa is probably by the inhibition of that enzyme.
...
PMID:Vaginal contraceptive activity of hyaluronidase and cyclooxygenase (prostaglandin synthetase) inhibitors in the rabbit. 392 8
