Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two children with advanced Wilms' tumor and one with extensive nephroblastomatosis showed artifactually elevated white blood cell (WBC) counts due to circulating mucin. Wilms' tumor is known to produce mucin identifiable in serum, urine, and touch imprints. To our knowledge, circulating mucin has not been described in nephroblastomatosis. When patients' blood was mixed with lysing reagent in the Ortho ELT-800, mucin was precipitated by acetic acid; this was confirmed by microscopy. Precipitates were counted as nuclei, producing abnormal WBC counts and histograms. When measured by the Ortho ELT-8/ws using osmotic lysis, the WBC counts matched hemocytometer counts. Mucin was not seen on Wright-stained smears but was evident with alcian blue staining and was largely abolished by hyaluronidase. Treatment led to disappearance of the artifactual WBC elevation.
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PMID:Circulating mucin in Wilms' tumor and nephroblastomatosis. Effect on leukocyte counts. 245 92

The Unani System of Medicine also known as Greeko-Arab medicine, founded by Hippocrates is based on the concept of equilibrium and balance of natural body humours (blood, bile, black bile and phlegm). The imbalance in the quality and quantity of these humours leads to diseases whereas restoration of this balance maintains health of a person. The treatment methodology of diseases is based on four therapeutic modalities viz. Regimental therapy, Dieto-therapy, Pharmacotherapy and surgery. Irsale Alaq (Leech or Hirudo therapy) is one of the most important and widely practised methods of regimental therapy used for local evacuation of morbid humours. It is a procedure of treatment with the use of medicinal leeches. It has been suggested and successfully practised by Greeko-Arab physicians in the management of musculoskeletal diseases, gynaecological disorders, chronic skin diseases, thromboembolic diseases, varicose veins, ENT disorders etc since long. According to Unani doctrine, the efficacy of leech therapy is attributed to the analgesic and resolvent activities of leeches. However, from modern perspective, the saliva of leech contains about 100 pharmacologically active biological substances like Hirudin, hyaluronidase, vasodilators, anesthetics, antibacterial, fibrinases, collagenase etc. These substances are injected into human body while sucking of the blood and are responsible for the analgesic, anti inflammatory and anesthetic effects of leech therapy.
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PMID:Leech therapy- a holistic approach of treatment in unani (greeko-arab) medicine. 2273 88