Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Strains of M-type 12 streptococci from 18 patients with acute glomerulonephritis and 18 patients with uncomplicated pharyngitis were analyzed for in vitro production of streptolysin O, diphosphopyridine nucleotidase, hyaluronidase, streptokinase, streptolysin S, proteinase, hyaluronic acid, and fibrinogen-precipitating factor. In addition, relations to blood group antigens, lysogeny, and susceptibility to bacteriophage were determined. No significant differences were found between strains from nephritic and nonnephritic patients. By not indicating a role in the pathogenesis of poststreptococcal acute glomerulonephritis for any of the factors studied, these observations diminish the probability that these factors are of specific importance in this disease and thus direct our attention elsewhere.
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PMID:Extracellular factors, blood group antigens, and bacteriophage of nephritogenic and nonnephritogenic strains of M-type 12 streptococci. 50 Nov 50

The families of 21 patients with acute rheumatic fever (ARF) and 44 patients with acute glomerulonephritis (AGN) in Trinidad were examined in their homes. The ARF and AGN families were equally large and crowded and they lived in the same largely rural areas. However, only 22% of the ARF family members had skin infections in contrast to 61% of the AGN family members. Sixty-eight per cent of skin infections in ARF families and 69% of skin infections in Agn families yielded group A streptococci. Throat cultures were positive in 19% of ARF family members and 25% of AGN family members. Thirty-two per cent of 51 group A strains isolated from ARF family members (29 from throat, 22 from skin) were M11 or "M41" strains which were associated with ARF during the study, while only 8% were M1, T4 (MNT or 60) or M55 strains which were associated with AGN. In contrast, 49% of 171 group A strains isolated from Agn family members (64 from throat, 107 from skin) were M1, T4 (MNT or 60) or M55 while only 10% were M11 or "M41." Serum antibody titers were similar in both groups: antistreptolysin-0 titers were not markedly increased in either while anti-hyaluronidase and/or antideoxyribonuclease-B titers were increased in both. Evidence of subclinical AGN was found equally often in both groups: 6% of each had abnormal urine and 4% of each had decreased serum complement while 2% of the ARF and 3% of the AGN family members had both abnormal urine and decreased serum complement.
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PMID:The families of patients with acute rheumatic fever or glomerulonephritis in Trinidad. 88 15

Since the discovery of streptococci by the surgeon of Vienna, Theodor Billroth, more than 100 years ago, they have proved to be a bacterial group of great medical and epidemiological importance. The classification in growth-characteristics on blood culture mediums (alpha-, beta- and gamma-hemolysis) has been detached by the evidence of group specific cell wall antigens. The antigene extraction described by Lancefield can distinguish at least 21 serogroups (A-T). They have also taken over the historical names (S. pyogenes, S. agalactiae etc.). In addition to group relationship the antigen structure of the streptococci cell wall (carbohydrates, peptidoglycanes, M-T-R-proteins and others) is responsible for antigenetic and pathogenetic conditions. Some species of streptococci do also excrete exotoxines (streptolysin, hyaluronidase, bacteriocines, erythrogenic toxins) with antigenetic and pathogenetic significance. Infections with streptococci of the serogroup A, B, D and H are numerously and medically significant. There is a great interest in infections due to A streptococci (pharygitis, impetigo, erysipel, scarlatin fever). The known non-purulent diseases following A streptococci infections (acute rheumatoid fever, acute glomerulonephritis) are streptococcal specific reactions for the individual. Some antigens of the cell wall and also some exotoxines react in human beings as autoantigenes. Human beings are the most important reservoir for streptococci. Nearly 20% of a population have A streptococci in their upper respiratory tract.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Microbiology of streptococcal infections]. 397 68