Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathogenicity and presence of serovar-specific hemagglutinating (HA) antigens of Haemophilus paragallinarum serovar B reference strains 0222 and Spross and field isolates 24268 and 24317 were investigated. Chickens challenged with all strains except strain 0222 showed clinical signs of infectious coryza. For all four strains, challenged chickens had intrasinus lesions and were colonized by the challenge organism. Before and after hyaluronidase treatment, strains 0222, 24268, and 24317 showed HA activity against formaldehyde-fixed chicken erythrocytes but not against fresh chicken erythrocytes. Strain Spross expressed HA activity only after treatment. In cross-hemagglutination-inhibition tests, the four serovar B strains cross-reacted with each other but not with serovar A and C strains. Cross-adsorption tests indicated that strain 24317 has a wider range of HA antigens than the other two strains. Our results indicated that H. paragallinarum serovar B strains are pathogenic for chickens and that they possess six different HA antigens, one of which is specific for serovar B strains.
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PMID:Pathogenicity and serovar-specific hemagglutinating antigens of Haemophilus paragallinarum serovar B strains. 214 63

Four field isolates (S4, S10, S15, and S17) of Haemophilus paragallinarum were recovered from chickens affected with infectious coryza in widely separated regions of Japan. Their hemagglutinating (HA) activity and immunological properties were compared with those of strain 221 of serovar A/1 and strains Modesto and S1 of serovar C/2. When treated with potassium thiocyanate or hyaluronidase, all the isolates showed HA activity against formaldehyde-fixed chicken erythrocytes but not against fresh chicken erythrocytes. In the hemagglutination-inhibition (HI) test, the isolates cross-reacted with strains Modesto and S1 but not with strain 221. The immunological properties of these isolates, as determined by cross-protection tests, were similar to those of strain S1 and, to a lesser degree, strain Modesto, but not to strain 221. Our results indicated that the four field isolates belong to serovar C/2 and that the HI test is a suitable method for serotyping H. paragallinarum.
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PMID:Hemagglutinating activity and immunological properties of Haemophilus paragallinarum field isolates in Japan. 277 98