Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Capsular and somatic serotyping was performed on 79 cultures of Pasteurella multocida from rabbits. Of these isolates, 74 were capsular type A as determined by the staphylococcal hyaluronidase decapsulation test and five were type D by the acriflavine flocculation test. Somatic type 12 was the dominant serotype, and the remainder (type 1, 3, 4 and 11) were less frequent as determined by the gel diffusion precipitin test. This report is in general agreement with other recent reports with rabbit isolates and collectively they provide important serotype and epizootiological information that will be useful in the control and prevention of rabbit pasteurellosis.
 ...
PMID:Capsular and somatic types of Pasteurella multocida from rabbits. 681 62

According to the genetic relationships among Gram-negative bacilli the genus Pasteurella is included with the genus Haemophilus and the genus Acinobacillus within the family Pasteurellacae. Pasteurella multocida, the type species, is responsible for the majority of human Pasteurella infections. P. multocida is a member of the normal flora in the upper respiratory tract of many mammals or birds. It causes sporadic or epidemic diseases among different animal species, particularly pneumonia and atrophic rhinitis in swine in intensive breeding stations. The most common human infection with P. multocida is a local cellulitis following dog or cat bites and scratches. Serious local complications are sometimes responsible for prolonged disability. The respiratory tract is the second human source of P. multocida isolates. The frequency of recovery of P. multocida from oropharynx of apparently healthy pig breeders suggests that respiratory pasteurellosis could be an occupational disease. The mechanisms of virulence of P. multocida are unclear. Several factors are involved: capsules preventing phagocytosis, a dermonecrotic toxin causing experimental atrophic rhinitis, hyaluronidase, neuraminidase and proteases. Penicillin is considered to be the drug of choice for Pasteurella infection. Tetracyclin is efficient for bites but has no bactericidal effect. Oxacillin, first-generation cephalosporins, macrolides and aminoglycosides have poor activities. In the case of beta-lactamase producing strains a bactericidal effect could be achieved with fluoroquinolones or third generation cephalosporins.
 ...
PMID:[Pasteurelloses]. 777 Mar 88