Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In Neisseria meningitidis strains isolated from patients with meningococcal infection and from carriers, the presence of plasmids has been detected by the modified method of H. C. Bernboim and J. Doly. The strains have been studied with respect to their pathogenicity and sensitivity to antibacterial substances. No correlation between the presence of plasmids and pathogenicity factors, such as antilysozyme activity, the presence of hyaluronidase and the positive reaction to Congo red, resistance to penicillin, serogroup and the sources of isolation, has been established.
 ...
PMID:[Meningococcal plasmids]. 250 Aug 19

To find out the epidemiological role of the carriers of hyaluronidase-positive meningococcal strains, their spread in the foci of meningococcal infection, as well as outside these foci, was studied. For this purpose, altogether 5059 persons from 40 family foci of infection and 40 organized groups were examined. The number of carriers of hyaluronidase-active meningococci, detected among those of them who had contacts with sick persons, was 13 times greater than among the persons having no such contacts. In preschool institutions with unfavorable morbidity situation this number was 16 times greater than in those with favorable situation. In the family foci carriers of hyaluronidase-active meningococci constituted 80-88 %. The percentage of the carriers of hyaluronidase-active meningococci causing cases of the generalized form of meningococcal infection varied in different groups. According to the results obtained in this study, the threshold percentage of such carriers constituted 30 in preschool institutions, 36 in boarding schools and 50 in common school and in hostels for adults.
 ...
PMID:[Epidemiological significance of carriers of hyaluronidase-active meningococci]. 308 5

The present work is based on the direct relationship, revealed in our investigations, between the hyaluronidase activity of meningococcal strains and their capacity to penetrate into the blood and the liquor. The use of the intranasal route (i.e. the natural route) for infecting previously untreated mice with meningococci in the presence of hyaluronidase made it possible to follow the generalized form of meningococcal infection in all its stages from the period of incubation and microbial invasion to bacteriemia, accompanied by the penetration of the infective agent into the meninges, and toxinemia. This route of infection ensured the penetration of the infective agent, but the natural specific resistance of mice to meningococci prevented their multiplication with the subsequent liberation of a sufficient amount of endotoxin killing the animals. To overcome natural immunity and increase toxicity, actinomycin D was injected intraperitoneally in a volume of 0.5 ml (5 gamma) simultaneously with the administration of the microbial culture and hyaluronidase, thus ensuring 40-60% mortality among the animals. Our model of the generalized form of meningococcal infection can be used in the study of pathogenesis and for the development of the methods of treatment and microbiological diagnosis.
 ...
PMID:[Natural reproduction of all stages of a generalized meningococcal infection in mice]. 643 17

The degree of the antilysozyme activity (ALA) of 430 Neisseria meningitidis strains isolated from 379 healthy carriers in 11 closed groups with different epidemiological situation and in 3 family foci was studied by the method of delayed antagonism. 87% of the strains exhibited ALA in a concentration of lysozyme between 1 and 10 micrograms per ml of the medium; about 11% of them were highly active, inactivating 20 and 25 micrograms of lysozyme per ml. ALA was shown to be the constant sign of carriership. The ALA of 39 strains isolated in cases of prolonged carriership (exceeding 2 weeks) was essentially higher than the ALA of 20 strains obtained in a single isolation. N. meningitidis strains of groups A, B and C, mostly responsible for the appearance of the generalized forms of diseases, were essentially less active than N. meningitidis strains of groups X, Y, Z, 29E, W-135, as well as strains not classified with any group. No correlation between ALA and the presence or absence of hyaluronidase was noted. Analysis of the data obtained in this study revealed that the ALA of N. meningitidis strains isolated in closed groups and families was not linked with the presence or absence of morbidity in the generalized forms of meningococcal infection and the spread of carriership in these groups, but reflected only differences in the serological picture of strains circulating there. The role of ALA in the formation of prolonged N. meningitidis carriership requires further study.
 ...
PMID:[The antilysozyme activity of the meningococci isolated from bacterial carriers in closed collectives with different epidemiological situations]. 806 8