Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.36 (
hyaluronidase
)
4,606
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The study was undertaken to evaluate serum
hyaluronidase
activity in patients with spondyloarthropatgies and to develop criteria for their differential diagnosis. The author's methods for evaluating serum
hyaluronidase
activity, which were based on that the formation of a clot of ethacridine lactate (rivanol) with hyaluronic acid is in inverse proportion to its depolymerization under the action of
hyaluronidase
, were used. Enhanced serum
hyaluronidase
activity was seen in patients with spondyloarthropathies as compared with the control group (p < 0.0010, which was most evident in
psoriatic arthritis
. With the diagnostic level of
hyaluronidase
activity of 4 scores or more, the diagnostic sensitivity of the method in the differential diagnosis of
psoriatic arthritis
and other spondyloarthropathies was 92% and its diagnostic specificity was 86%.
...
PMID:[Criteria for the differential diagnosis of spondyloarthropathies, by determining serum hyaluronidase activity]. 2052 40
