Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.36 (hyaluronidase)
 4,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of antiserum raised against rat urinary (renal) hyaluronidase has been examined in rats subjected to antidiuretic stimuli (water-deprivation or vasopressin infusion). Prior administration of antiserum abolishes the reduction in medullary and papillary extractable hexosamine which normally accompanies antidiuresis. Antiserum against rat testicular hyaluronidase was found to be without effect during water-deprivation. Water-loading significantly increased the level of extractable hexosamine. The findings are considered in relation to previous observations on the effects of antisera on renal and urinary composition and collecting duct morphology under identical experimental conditions. It is suggested that a functional relationship exists between the net degradation of medullary mucopolysaccharides by hyaluronidase and the concentrating capacity of the kidney.
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PMID:Renal medullary hexosamine content following antidiuresis and water-loading in the rat. Effects of antisera against rat urinary and testicular hyaluronidase. 719 63

An investigation has been carried out into the formation of dilated lateral intercellular spaces in the medullary collecting duct of the rat kidney following water deprivation or infusion of vasopressin. Dilation is conspicuous under these conditions, by comparison with normally hydrated controls, but its appearance is prevented by prior treatment of rats with antiserum raised against urinary (renal) hyaluronidase. Antiserum against testicular hyaluronidase is without effect. The presence or absence of dilatations in the lateral intercellular space correlates closely with previous findings on the ability or inability of rats to concentrate their urine under identical experimental conditions. It is concluded that urinary (renal) hyaluronidase plays an important role in the formation of such dilatations and that these facilitate the process of urinary concentration.
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PMID:The effect of antidiuretic stimuli on the morphology of the lateral intercellular spaces in the medullary collecting duct of the rat. 733 49