Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

12 human embryos and fetuses (in weeks 4 to 20 of the intrauterine life) were studied using the methods according to Lojda for the activity of the following enzymes: alkaline and acid phosphatases (AlP, AcP), acid nonspecific esterase (AE), ATP- splitting enzymes (ATP-ase), beta-glucuronidase, aminopeptidases A and M (APA, APM), dipeptidylpeptidase IV (DPP IV), gamma-glutamyltransferase (GGT), succinate dehydrogenase (SDH), and glycero-3-phosphate dehydrogenase (alpha-GPDH). Glycogen content was determined by PAS method. In the youngest embryos, a high activity of DPP IV was recorded in the epithelium of differentiating primitive glandular tubules. Activity of other peptidases was low. The activity of AcP was found in tubular epithelium and mesenchymal cells. After week 7, glycogen was present in the supranuclear zone of tubule epithelium. In older fetuses, especially after week 15 of the intrauterine life, the activity of all studied enzymes gradually intensifies. In acinic anlage, a high activity of DPP IV was observed, activity of APM and GGT increased, activity of APA was lower. A relatively high activity of peptidases was recorded even in the epithelium of ducts. The capillaries showed a high activity of AlP and ATP-ase.
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PMID:Histochemistry of enzymes in the pancreas of human embryos. 183 90

Activities of the following enzymes were assessed in cryostat sections of human embryonic and fetal placentae aged 7 to 22 weeks of the intrauterine life using the standard methods recommended by Lojda et al. (1978): alkaline phosphatase (AIP), and acid phosphatase (AcP), non-specific esterase (ANE), ATP-cleaving enzymes (ATP-ase), beta-glucuronidase, thiamine pyrophosphatase, dipeptidylaminopeptidase IV (DPP IV), aminopeptidase A and M (APA, APM), gamma-glutamyltransferase (GGT), glycero-3-phosphate dehydrogenase and succinate dehydrogenase (alpha-GPDH, SDH). Since week 7 high activity of AIP has been proved in the apical zone of the plasmodiotrophoblast. At the same time the DPP IV activity appeared in the plasmodiotrophoblast, in the stroma of villi, and, latter on, in vascular endothelium. In the fetal placenta the APA activity was pronounced both in the cytotrophoblast and the stroma of villi. The activities of AcP and ANE were relatively weak. In the course of development the activities of most enzymes were gradually increasing.
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PMID:Histochemistry of some enzymes in human embryonic and fetal placentae. 215 Oct 77

The distributions of the lysosomal enzymes [acid phosphatase (AP), N-acetyl-beta-D-glucosaminidase (NAG), beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal), dipeptidylpeptidase II (DPP II)] and of the membrane-bound proteases [aminopeptidase M (APM), aminopeptidase A (APA), gamma-glutamyltransferase (GGT), dipeptidylpeptidase IV (DPP IV)] were investigated in the normal human adult and foetal anterior segment by histochemical methods. The distribution of these hydrolases varied between ocular tissues. The most active enzymes in the adult corneal epithelium and endothelium were AP, beta-Gluc, NAG, beta-Gal and GGT; in the keratocytes, APM, APA, beta-Gluc and GGT predominated. The adult trabecular meshwork cells were stained by AP, beta-Gluc, NAG, APM, GGT, DPP II and DPP IV. The enzymes AP, beta-Gluc, APM and APA, however, displayed greater activity in the endothelium of Schlemm's canal. The adult ciliary epithelium stained strongly for all lysosomal hydrolases; GGT was the most active protease here. Differences in enzyme activity were noted in some tissues when foetal and adult anterior segments were compared. There appeared to be a decrease in the activity of some enzymes with age and post-mortem delay greater than 24 h. The function(s) of each enzyme and their possible roles in the respective tissues are discussed.
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PMID:Histochemical survey of the anterior segment of the normal human foetal and adult eye. 822 58