Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper presents experimental asbestosis treated with hydroxy piperquin phosphate (HPQP) in dogs. Results showed that the total cell number of bronchoalveolar lavage fluid, the viability of alveolar macrophages and the enzyme activities of lactate dehydrogenase, acid phosphatase and beta-glucuronidase of alveolar macrophages in treated dogs were higher than those in exposed dogs, asbestos fibers contents in the lungs and the mean scores of lung lesions in the treated dogs were markedly less than those in the exposed dogs. These findings support that HPQP may play a role in protecting alveolar macrophages from damage and inhibiting the progression of lung fibrosis, and that the clinical application of HPQP is somehow evidenced by this study.
Hua Xi Yi Ke Da Xue Xue Bao 1991 Jun
PMID:[Pathological observation of experimental asbestosis treated by hydroxy piperquin phosphate in dogs]. 178 56

We determined and compared the beta-glucuronidase (beta-G) activity among strains of B. fragilis and E. coli under the optimum condition. Results showed that the mean beta-G activity of strain B. fragilis ATCC25285 was 94.7u. B. fragilis ATCC25285 strain was selected as the model strain to establish the animal model of bilirubin gallstones because its beta-G activity was obviously higher than that of B. fragilis CDC14462 and E. coli 3362 (O157K88) strain.
Hua Xi Yi Ke Da Xue Xue Bao 1991 Jun
PMID:[Determination and comparison of beta-glucuronidase activity among strains of B. fragilis and E. coli]. 178 64

A comparative study of Bacteroides fragilis and E. coli bacterial infection in the biliary tract in relation to the pathogenesis of pigment stone formation was carried out on the basis of gallstone rabbit's model of anaerobic bacterial infection. One hundred and twenty Japanese hybrid big-ear white rabbits were randomly divided into four groups: 14 in control group, 31 in B. fragilis (BF) group, 42 in E. coli group and 33 in the mixed group. In the experimental groups we successfully made gallstone formation in aerobic, anaerobic and mixed bacterial infections in biliary tracts respectively. On 7, 15 and 30 postoperative days the survival rabbits were sacrificed for investigations. Our experiments demonstrated that the incidence and amount of stone formation in the mixed group were the highest among the experiment groups. The key point to preclude stone formation was to control the bacterial infection in the biliary tract as early as possible. The results suggested that the ability of production of beta-glucuronidase in BF group was significantly higher than that in E. coli group. The author considered that BF was more important than E. coli in the pathogenesis of calcium bilirubinate gallstone formation.
Hua Xi Yi Ke Da Xue Xue Bao 1991 Sep
PMID:[A comparative study of Bacteroides fragilis and E. coli related to the pathogenesis of calcium bilirubinate gallstones]. 181 25

The aim of the present study is to determine the beta-glucuronidase changes in bile and hepatobiliary tissue of rabbit model having pigment gallstone by means of biochemical and enzymehistochemical assay methods. The result showed both of the bacterial and non-bacterial beta-glucuronidase take part in the course of pigment gallstone formation. The bacterial beta-glucuronidase level increased quickly before the formation of gallstone, then decreased with control of bacterial infection. Non-bacterial beta-glucuronidase increased slowly in pro-formation stage of gallstone, then kept high level for long period of time. The relationship between beta-glucuronidase and pigment gallstone formation is also discussed.
Hua Xi Yi Ke Da Xue Xue Bao 1990 Jun
PMID:[The changes of beta-glucuronidase in rabbit model with calcium bilirubinate stone]. 220 52