Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The recovery of mast cells in adult rats after depletion induced by polymyxin-B has been studied. At days 17-18 after depletion the number of identifiable mast cells in the peritoneal fluid reached 3 X 10(6) cells/rat. Mast cell granule constituents such as histamine, heparin, mast cell protease and beta-glucuronidase increased steadily during the observation period, whereas the amount of N-acetyl-beta-glucosaminidase decreased during the first 2 weeks and was thereafter constant. At 2 weeks after depletion the peritoneal mast cells were biochemically restored. From 14 to 34 days (end of experimental period) cell growth occurred with a simultaneous accumulation of the various mast cell granule constituents.
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PMID:Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B. 626 1

Padawer has proposed that rat mast cells in the peritoneal cavity have an extended lifespan and under normal conditions exhibit little turnover of their secretory granules. We have examined several constituents of the granules as part of a study of the structure and function of these organelles. The previously described increase in volume of mast cells with age of the rats from which the cells are obtained is associated with an increase in the quantity of histamine, heparin, beta-glucuronidase and mast cell protease. While the former 3 granule components increase in parallel with mast cell volume, the increase in protease between 3- and 6-month-old rats is in excess of cell volume and the other 3 granule component. Granules from rats 1 month or less in age tend to be more difficult to isolate with their surrounding membranes intact.
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PMID:Effect of age on mast cell granules. 723 98