Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Protein leakage was used as a quantitative measure of poliovirus-induced cellular injury under suspended cell culture conditions. The requirements for protein leakage were studied in detail and it was established that events early in the infectious cycle which depend upon viral protein synthesis were responsible for cell damage. Extralysosomal
beta-glucuronidase
appeared in infected cells before the onset of protein leakage and release of newly synthesized virus.
Hydrocortisone
treatment of infected cells resulted in only a slight delay in the release of
beta-glucuronidase
from lysosomes and protein and virus from cells. These results suggest that events associated with poliovirus synthesis trigger the release of lysosomal hydrolases which in turn injure the plasma membrane, allowing cytoplasmic proteins and virus to leak out of the cell.
...
PMID:Poliovirus-induced Cellular Injury. 1678 93
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