Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of pre- and postoperative administration of methylprednisolone (5, 10, 15 mg/kg/day) was studied on 50 cases of major neurosurgical operation. The serum level of beta-glucuronidase was also analyzed in 20 cases so as to determine whether it could be useful as an indicator of post operative brain edema. Methylprednisolone seemed to be effective in the cases administrated in the dosage of 10, 15 mg/kg/day. However, several kinds of postoperative infections were seen in the cases administrated 15 mg/kg/day. The results may suggest that the dosage tested, 10 mg/kg/day, causes little side effects while it is clinically effective. The serum level of beta-glucuronidase tended to increase from the second postoperative day to the seventh day. Those increase were remarkably in the cases with brain edema. Recovery of beta-glucuronidase level was earlier in the cases with 10 mg/kg/day administrated rather than in the cases with 5 mg/kg/day administrated. These results suggest that the measurement of serum beta-glucuronidase level may be useful for evaluating the degree of brain edema.
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PMID:[A study of the optimum dose of a glucocorticoid, methylprednisolone sodium succinate, before and after neurosurgical major operations--relationship between beta-glucuronidase level and post operative brain edema]. 390 89

The effect of corticosteroid therapy on the broncho-alveolar cell response, the changes in activity of some lysosomal enzymes and the protein and lipid biosynthesis rates in lung tissue of normal rabbits and of rabbits after induction of an acute inflammation by the intravenous injection of complete Freund's adjuvant (CFA) 0,2 ml/kg body weight was investigated. Three intramuscular injections of methylprednisolone acetate (Depo-Medrol) 1,2 mg/kg over a period of 8 days reduced the mean total broncho-alveolar free cell yields significantly. The percentages of lymphocytes and granulocytes were decreased. The increase in the macrophage percentage was associated with a significant increase in the acid phosphatase activity of the broncho-alveolar cells. The beta-glucuronidase activity, on the other hand, was lowered in alveolar cells and even significantly suppressed in lung tissue. Protein and lipid biosynthesis was significantly retarded in lung tissue 8 days after the start of therapy. Administration of a single dose of CFA 0,2 ml/kg evoked an acute lung inflammation and a significant increase in total alveolar free cell yields. The macrophage percentage was reduced and the lymphocyte numbers doubled, whereas the granulocyte percentage increased more than sevenfold. The change in the percentage distribution of granulocytes may be associated with the marked increase in beta-glucuronidase activity of the cells as well as of the lung tissue. In the inflammatory phase, protein biosynthesis was significantly increased but lipid synthesis was not affected. Corticosteroid therapy in animals treated with adjuvant reversed all the effects of CFA. It has very pronounced anti-inflammatory action and a catabolic effect on protein and lipid metabolism.
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PMID:The effect of corticosteroid therapy on lysosomal enzymes and protein and lipid metabolism in rabbit lung after administration of Freund's adjuvant. 713 14