Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: EC:3.2.1.31 (
beta-glucuronidase
)
7,680
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Urinary
beta-glucuronidase
activity as a measure of renal tubular damage was studied in 23 patients receiving 43 courses of cis-diamminedichloroplatinum(II) therapy. A 250% increase in urinary
beta-glucuronidase
activity was noted after therapy, compared with values before therapy. There were no patients who sustained
renal insufficiency
as evidenced by more commonly used and coarser parameters of renal function. This marked rise in urinary
beta-glucuronidase
activity was felt to indicate tubular toxicity due to the cis-diamminedichloroplatinum(II) not measured by the usual parameters of renal function.
...
PMID:Nephrotoxicity of cis-diamminedichloroplatinum(II) as measured by urinary beta-glucuronidase. 719 87
