Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present paper was designed to the study of cerebral edema induced by intracarotid infusion of dinitrophenol. The determinations included variations in three lysosomal enzymes (acid phosphatase, cathepsin C and beta-glucuronidase), Na+-K+-ATP-ase, changes in cerebral RNA and protein concentrations and the synthesis of these macromolecules in vitro. In experimental brain edema a drastic drop in the activity of lysosomal enzymes took place. The acid phosphatase decreased to less than 30% of controls. Cathepsin C and beta-glucuronidase were reduced about 30% and 50% of control levels respectively. Protein concentration in the cerebral tissue also decreased by more than 50%. The concentration of RNA, RNA synthesis, and the level of Na+-K+-ATP-ase remained unchanged. Protein synthesis was stimulated by 75% (against controls). All these phenomena were suppressed when the animals subjected to the action of dinitrophenol were concomitantly treated with the antiacidotic substance, tris (hydroxymethyl) aminomethane.
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PMID:Biochemical changes in the rat brain associated with dinitrophenol-induced brain edema. 15 61

The effect of posttraumatic steroid treatment (6-methylprednisolone) on the stability of lysosomal membranes in the cat brain is studied. The share of free activity of the lysosomal enzymes beta-glucuronidase and N-acetylhexosaminidase indicates the grade of membrane stability. The results demonstrate an increased stability of lysosomal membranes in grey as well as in white matter after posttraumatic steroid treatment. This regarded as an important aspect of the protective effects of steroid treatment in posttraumatic brain edema.
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PMID:The protective effect of steroid treatment on lysosomal enzymes after cold lesion of the cat brain. 51 34

The effects of pre- and postoperative administration of methylprednisolone (5, 10, 15 mg/kg/day) was studied on 50 cases of major neurosurgical operation. The serum level of beta-glucuronidase was also analyzed in 20 cases so as to determine whether it could be useful as an indicator of post operative brain edema. Methylprednisolone seemed to be effective in the cases administrated in the dosage of 10, 15 mg/kg/day. However, several kinds of postoperative infections were seen in the cases administrated 15 mg/kg/day. The results may suggest that the dosage tested, 10 mg/kg/day, causes little side effects while it is clinically effective. The serum level of beta-glucuronidase tended to increase from the second postoperative day to the seventh day. Those increase were remarkably in the cases with brain edema. Recovery of beta-glucuronidase level was earlier in the cases with 10 mg/kg/day administrated rather than in the cases with 5 mg/kg/day administrated. These results suggest that the measurement of serum beta-glucuronidase level may be useful for evaluating the degree of brain edema.
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PMID:[A study of the optimum dose of a glucocorticoid, methylprednisolone sodium succinate, before and after neurosurgical major operations--relationship between beta-glucuronidase level and post operative brain edema]. 390 89