Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

On the basis of their origin and morphologic and cytochemical characteristics, atypical mononuclear cells (AMNC) in the peripheral blood of patients with the syndrome of infectious mononucleosis caused by the Epstein-Barr (EB) virus can be classified into three groups, from I to III. The AMNC groups I are the most numerous (76.36% +/- 2.50%). A larger part of these cells have the characteristics of more or less altered lymphoblasts and the smaller part of large pyroninophilic cells and "reactive immunoblasts", and meant to have developed from T lymphocytes. These are the most numerous in the acute phase of the disease, which correlates with the most significant increase of T lymphocytes values. A very high percentage (84.00% +/- 7.30%) of the AMNC group I contains acid phosphatase isoenzyme 3 and acid non-specific esterase (82.43% +/- 7.76%), a considerable percentage of beta-glucuronidase (58.75% +/- 13.99%), and acid phosphatase isoenzyme 1 (51.20% +/- 10.81%). A small percentage of these cells contains acid phosphatase isoenzyme 5 resistant to the action of L+tartaric acid. In 39.04% +/- 8.72% of the lymphocytes in the peripheral blood of the examined patients and in the two thirds and nearly three fourths of the AMNC group I, the presence of acid phosphatase manifests itself in the form of scattered granules. The positive reaction to non-specific esterase (pH 7.8-8) in 39.72% +/- 8.44% lymphocytes of the peripheral blood of the patients and in 59.26% +/- 10.09% of the AMNC group I manifests itself in the form of scattered granules.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Morphological and cytochemical characteristics of atypical mononuclear cells in the blood of patients with the syndrome of infectious mononucleosis caused by Epstein-Barr virus. 750 31

In 30 patients with mononucleosis-like syndrome (MLS) caused by cytomegalovirus (CMV), diagnosed on the basis of clinical symptoms, haematological & serological changes (after excluding Epstein-Barr virus, HAV, HBV and HCV infections), the following measurements were done weekly during consecutive two months': bilirubin concentration, aspartate & alanine aminotransferases (AST & ALT), alkaline phosphatase (ALP), beta-glucuronidase (B-GR), and gamma-glutamyltranspeptidase (GGTP) activity. Increase in bilirubin concentration was found in 6% of patients, increase of AST and ALT activity--in 70%, GGTP--in 50%, ALP--in 25%, and of B-GR--in 16% of the subjects. The highest bilirubin concentration, and high levels of AST, ALT, and B-GR were noted in the 2nd week of infection, whereas the peak activity of ALP and GGTP was found in the 3rd week of the disease. In all patients normalization of bilirubin concentration was earliest (5th week of infection); followed by decrease of AST, ALT, B-GR, and ALP activity (7th week), and subsequently--that of GGTP (8th week of the disease). The results of the investigations have shown that in the course of MLS the changes of hepatic activity are limited and transient; they return to normal synchronously with the withdrawal of clinical symptoms (4th-6th week of the disease), without permanent measurable consequences. In patients with MLS and increase AST & ALT activity (400-600 iu) as well as slight increased of bilirubin concentrations hepatitis C,A and B should be excluded. In has not been established so far whether the changes of hepatic function during MLS are the consequence of direct infection by CMV, reactivation of the primary occult infection (asymptomatic), or re-infection by a different serotype.
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PMID:[Biochemical changes of liver damage factors in the course of mononucleosis like syndrome caused by cytomegalovirus]. 1134 95