Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

12 human embryos and fetuses (in weeks 4 to 20 of the intrauterine life) were studied using the methods according to Lojda for the activity of the following enzymes: alkaline and acid phosphatases (AlP, AcP), acid nonspecific esterase (AE), ATP- splitting enzymes (ATP-ase), beta-glucuronidase, aminopeptidases A and M (APA, APM), dipeptidylpeptidase IV (DPP IV), gamma-glutamyltransferase (GGT), succinate dehydrogenase (SDH), and glycero-3-phosphate dehydrogenase (alpha-GPDH). Glycogen content was determined by PAS method. In the youngest embryos, a high activity of DPP IV was recorded in the epithelium of differentiating primitive glandular tubules. Activity of other peptidases was low. The activity of AcP was found in tubular epithelium and mesenchymal cells. After week 7, glycogen was present in the supranuclear zone of tubule epithelium. In older fetuses, especially after week 15 of the intrauterine life, the activity of all studied enzymes gradually intensifies. In acinic anlage, a high activity of DPP IV was observed, activity of APM and GGT increased, activity of APA was lower. A relatively high activity of peptidases was recorded even in the epithelium of ducts. The capillaries showed a high activity of AlP and ATP-ase.
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PMID:Histochemistry of enzymes in the pancreas of human embryos. 183 90

The distributions of the lysosomal enzymes [acid phosphatase (AP), N-acetyl-beta-D-glucosaminidase (NAG), beta-glucuronidase (beta-Gluc), beta-galactosidase (beta-Gal), dipeptidylpeptidase II (DPP II)] and of the membrane-bound proteases [aminopeptidase M (APM), aminopeptidase A (APA), gamma-glutamyltransferase (GGT), dipeptidylpeptidase IV (DPP IV)] were investigated in the normal human adult and foetal anterior segment by histochemical methods. The distribution of these hydrolases varied between ocular tissues. The most active enzymes in the adult corneal epithelium and endothelium were AP, beta-Gluc, NAG, beta-Gal and GGT; in the keratocytes, APM, APA, beta-Gluc and GGT predominated. The adult trabecular meshwork cells were stained by AP, beta-Gluc, NAG, APM, GGT, DPP II and DPP IV. The enzymes AP, beta-Gluc, APM and APA, however, displayed greater activity in the endothelium of Schlemm's canal. The adult ciliary epithelium stained strongly for all lysosomal hydrolases; GGT was the most active protease here. Differences in enzyme activity were noted in some tissues when foetal and adult anterior segments were compared. There appeared to be a decrease in the activity of some enzymes with age and post-mortem delay greater than 24 h. The function(s) of each enzyme and their possible roles in the respective tissues are discussed.
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PMID:Histochemical survey of the anterior segment of the normal human foetal and adult eye. 822 58