Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.2.1.31 (beta-glucuronidase)
 7,680 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Muscle swelling in connection with training-induced protection against exercise-induced damage and the disappearance of the protective adaptation after termination of training was studied in male NMRI-mice, aged 8 weeks at the beginning of the experiment. Mice were randomly assigned to several different treatment groups (training, training-exercise, exercise, detraining, detraining-exercise, together with their respective controls). Training and prolonged exercise sessions were performed by running uphill (6 degrees) on a motor-driven treadmill. Muscle damage was estimated by the total activity of beta-glucuronidase and water content from the red parts of m. quadriceps femoris (MQF), m. soleus (MS), m. rectus femoris (MRF), and from m. triceps brachii (MTB). Training-induced protection was observed in MS after only one week of training. In MQF the protection was incomplete after 1 and 4 weeks' training. In MS the protection disappeared already one week after the cessation of training. In MQF the training-induced protection persisted in part for one week but after four-week's detraining no protection was observed. The present results suggest that diminution of muscle swelling forms part of the adaptation of skeletal muscle in resisting exercise damage, and, vice versa, increased susceptibility to exercise damage, which follows the termination of training, is linked to muscle reswelling.
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PMID:Training-induced protection and effect of terminated training on exercise-induced damage and water content in mouse skeletal muscles. 755 25

The relationships and time course of exercise-induced muscle damage, estimated by beta-glucuronidase activity and microscopy, to muscle swelling, estimated by muscle water content and microscopy, and to the serum activity of creatine kinase (CK) and the concentration of carbonic anhydrase III were studied in rats 2, 12, 48, and 96 h after 90 min of intermittent running uphill (+13.5 degrees) or downhill (-13.5 degrees) at a speed of 17 m/min. The injury was more pronounced in soleus after uphill running and in the red parts of quadriceps femoris and in the white part of vastus lateralis after downhill running, whereas triceps brachii was not damaged. Increase in muscle water content preceded the increase of beta-glucuronidase activity. Both running protocols similarly increased serum CK 2 h postexercise. After downhill running a second peak in serum CK was observed 48 h later. The CK changes were not in concert with the changes in muscle water content or beta-glucuronidase activity, suggesting that these responses may not be mechanistically (or causally) related.
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PMID:Running-induced muscle injury and myocellular enzyme release in rats. 786 48